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Detection of Infections by Computerized Capture of Peaks in Longitudinally Measured C-reactive Protein Levels

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Bibliographic Details
Title: Detection of Infections by Computerized Capture of Peaks in Longitudinally Measured C-reactive Protein Levels
Authors: Olav Sivertsen Garvik, Pedro Póvoa, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Henrik Frederiksen, Ming Chen, Ram Benny Dessau, John Eugenio Coia, Jens Kjølseth Møller, Kim Oren Gradel
Source: Biomarkers in Medicine. 17:635-642
Publisher Information: Informa UK Limited, 2023.
Publication Year: 2023
Subject Terms: Myeloid, Adult, Leukemia, C-Reactive Protein/metabolism, Acute/diagnosis, bloodstream infection, Sepsis/diagnosis, Bacteremia, acute myeloid leukemia, 3. Good health, C-reactive protein, Leukemia, Myeloid, Acute, C-Reactive Protein, inflammation, Sepsis, Humans, automatic capture, Biomarkers, Retrospective Studies
Description: We developed four algorithms for the automatic capture of C-reactive protein (CRP) peaks in 296 adult patients with acute myeloid leukemia who had bloodstream infection (BSI) episodes, negative blood cultures (BCs) or possible infections where no BCs were performed. The algorithms detected CRP peaks for 418-446 of the 586 documented BSI episodes (71.3-76.1%) and 2714-3118 of the 4382 negative BCs (61.9-71.2%). The four algorithms captured 382-789 CRP peaks in which there were neither BSI episodes nor negative BCs. We conclude that automatic capture of CRP peaks is a tool for the monitoring of BSI episodes and possibly other infections in patients with acute myeloid leukemia.
Document Type: Article
Language: English
ISSN: 1752-0371
1752-0363
DOI: 10.2217/bmm-2023-0419
Access URL: https://pubmed.ncbi.nlm.nih.gov/37962480
Accession Number: edsair.doi.dedup.....1f301e07b30940271e4b122bbed22e58
Database: OpenAIRE
Description
Abstract:We developed four algorithms for the automatic capture of C-reactive protein (CRP) peaks in 296 adult patients with acute myeloid leukemia who had bloodstream infection (BSI) episodes, negative blood cultures (BCs) or possible infections where no BCs were performed. The algorithms detected CRP peaks for 418-446 of the 586 documented BSI episodes (71.3-76.1%) and 2714-3118 of the 4382 negative BCs (61.9-71.2%). The four algorithms captured 382-789 CRP peaks in which there were neither BSI episodes nor negative BCs. We conclude that automatic capture of CRP peaks is a tool for the monitoring of BSI episodes and possibly other infections in patients with acute myeloid leukemia.
ISSN:17520371
17520363
DOI:10.2217/bmm-2023-0419