Sex-Specific Variances in Anatomy and Blood Flow of the Left Main Coronary Bifurcation: Implications for Coronary Artery Disease Risk
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| Název: | Sex-Specific Variances in Anatomy and Blood Flow of the Left Main Coronary Bifurcation: Implications for Coronary Artery Disease Risk |
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| Autoři: | Gharleghi, R, Zhang, M, Adikari, D, Mcgrath-Cadell, L, Graham, RM, Wentzel, JJ, Webster, M, Ellis, C, Ooi, SY, Beier, S |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 72:2130-2137 |
| Publication Status: | Preprint |
| Informace o vydavateli: | Institute of Electrical and Electronics Engineers (IEEE), 2025. |
| Rok vydání: | 2025 |
| Témata: | anzsrc-for: 4009 Electronics, FOS: Computer and information sciences, anzsrc-for: 4003 Biomedical engineering, anzsrc-for: 4012 Fluid Mechanics and Thermal Engineering, anzsrc-for: 0903 Biomedical Engineering, anzsrc-for: 4603 Computer vision and multimedia computation, FOS: Physical sciences, Atherosclerosis, Cardiovascular, Physics - Medical Physics, Statistics - Applications, Health Disparities, anzsrc-for: 40 Engineering, Heart Disease, 4012 Fluid Mechanics and Thermal Engineering, Women's Health, Applications (stat.AP), anzsrc-for: 0801 Artificial Intelligence and Image Processing, Medical Physics (physics.med-ph), sensors and digital hardware, anzsrc-for: 0906 Electrical and Electronic Engineering, Heart Disease - Coronary Heart Disease, 40 Engineering, 4.2 Evaluation of markers and technologies |
| Popis: | Studies have shown marked sex disparities in Coronary Artery Diseases (CAD) epidemiology, yet the underlying mechanisms remain unclear. We explored sex disparities in the coronary anatomy and the resulting haemodynamics in patients with suspected, but no significant CAD. Left Main (LM) bifurcations were reconstructed from CTCA images of 127 cases (42 males and 85 females, aged 38 to 81). Detailed shape parameters were measured for comparison, including bifurcation angles, curvature, and diameters, before solving the haemodynamic metrics using CFD. The severity and location of the normalised vascular area exposed to physiologically adverse haemodynamics were statistically compared between sexes for all branches. We found significant differences between sexes in potentially adverse haemodynamics. Females were more likely than males to exhibit adversely low Time Averaged Endothelial Shear Stress along the inner wall of a bifurcation (16.8% vs. 10.7%). Males had a higher percentage of areas exposed to both adversely high Relative Residence Time (6.1% vs 4.2%, p=0.001) and high Oscillatory Shear Index (4.6% vs 2.3%, p 14 pages, 5 figures |
| Druh dokumentu: | Article |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2025.3536161 |
| DOI: | 10.48550/arxiv.2311.18489 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40031780 http://arxiv.org/abs/2311.18489 |
| Rights: | IEEE Copyright arXiv Non-Exclusive Distribution CC BY |
| Přístupové číslo: | edsair.doi.dedup.....1f168505475a78a245b5b78af116f99a |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Studies have shown marked sex disparities in Coronary Artery Diseases (CAD) epidemiology, yet the underlying mechanisms remain unclear. We explored sex disparities in the coronary anatomy and the resulting haemodynamics in patients with suspected, but no significant CAD. Left Main (LM) bifurcations were reconstructed from CTCA images of 127 cases (42 males and 85 females, aged 38 to 81). Detailed shape parameters were measured for comparison, including bifurcation angles, curvature, and diameters, before solving the haemodynamic metrics using CFD. The severity and location of the normalised vascular area exposed to physiologically adverse haemodynamics were statistically compared between sexes for all branches. We found significant differences between sexes in potentially adverse haemodynamics. Females were more likely than males to exhibit adversely low Time Averaged Endothelial Shear Stress along the inner wall of a bifurcation (16.8% vs. 10.7%). Males had a higher percentage of areas exposed to both adversely high Relative Residence Time (6.1% vs 4.2%, p=0.001) and high Oscillatory Shear Index (4.6% vs 2.3%, p<br />14 pages, 5 figures |
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| ISSN: | 15582531 00189294 |
| DOI: | 10.1109/tbme.2025.3536161 |