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(Lack of) Effects of noradrenergic stimulation on human working memory performance

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Názov: (Lack of) Effects of noradrenergic stimulation on human working memory performance
Autori: Nadine Wanke, Jana Christina Müller, Klaus Wiedemann, Lars Schwabe
Zdroj: Psychopharmacology (Berl)
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2020.
Rok vydania: 2020
Predmety: Adult, Male, Cross-Over Studies, Dose-Response Relationship, Drug, Prefrontal Cortex, Yohimbine, Bayes Theorem, Adrenergic alpha-2 Receptor Antagonists, Norepinephrine, Young Adult, 03 medical and health sciences, Cognition, Memory, Short-Term, 0302 clinical medicine, Double-Blind Method, Avoidance Learning, Humans, Female, Cognition/physiology [MeSH], Double-Blind Method [MeSH], Memory, Short-Term/drug effects [MeSH], Noradrenaline, Prefrontal cortex, Bayes Theorem [MeSH], Working memory, Prefrontal Cortex/physiology [MeSH], Original Investigation, Male [MeSH], Avoidance Learning/drug effects [MeSH], Avoidance Learning/physiology [MeSH], Norepinephrine/pharmacology [MeSH], Cognition/drug effects [MeSH], Dose-Response Relationship, Drug [MeSH], Female [MeSH], Memory, Short-Term/physiology [MeSH], Yohimbine/pharmacology [MeSH], Adult [MeSH], Humans [MeSH], Adrenergic alpha-2 Receptor Antagonists/pharmacology [MeSH], Learned helplessness, Cross-Over Studies [MeSH], Young Adult [MeSH], Prefrontal Cortex/drug effects [MeSH], 10. No inequality
Popis: Rationale Working memory depends on prefrontal cortex functioning, which is particularly sensitive to levels of noradrenaline. Studies in non-human primates have shown that modest levels of noradrenaline improve working memory, and that higher levels of noradrenaline impair working memory performance. However, research in humans provided inconsistent findings concerning noradrenergic effects on working memory. Objective The present study aimed at assessing dose-dependent effects of yohimbine, an alpha-2 adrenoceptor antagonist, on working memory performance in healthy humans. We further aimed to explore a potential interactive effect between noradrenergic arousal and lack of control over aversive events on working memory performance. Methods We used a double-blind, fully crossed, placebo-controlled, between-subject design. Participants (N = 121) performed an adaptive n-back task before and after oral administration of either a placebo, 20 mg, or 40 mg yohimbine and a manipulation of controllability, during which participants could either learn to avoid electric shocks (controllability groups), had no instrumental control over shock administration (uncontrollability groups), or did not receive any shocks (no-shock control group). Results While no significant results of noradrenergic stimulation through yohimbine were obtained using conventional frequentist analyses, additional Bayesian analyses provided strong evidence for the absence of an association between pharmacological treatment and working memory performance. We further observed no effect of controllability and no interaction between noradrenergic stimulation and the manipulation of controllability. Conclusions Our results suggest that noradrenergic stimulation through yohimbine does not affect (non-spatial) working memory in healthy human participants.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-2072
0033-3158
DOI: 10.1007/s00213-020-05590-0
Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00213-020-05590-0.pdf
https://pubmed.ncbi.nlm.nih.gov/32583013
https://pubmed.ncbi.nlm.nih.gov/32583013/
https://link.springer.com/article/10.1007/s00213-020-05590-0
https://www.ncbi.nlm.nih.gov/pubmed/32583013
https://link.springer.com/content/pdf/10.1007/s00213-020-05590-0.pdf
https://repository.publisso.de/resource/frl:6466892
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....1ce7b7cc5e4b87e06d71b69f59ff4e07
Databáza: OpenAIRE
Popis
Abstrakt:Rationale Working memory depends on prefrontal cortex functioning, which is particularly sensitive to levels of noradrenaline. Studies in non-human primates have shown that modest levels of noradrenaline improve working memory, and that higher levels of noradrenaline impair working memory performance. However, research in humans provided inconsistent findings concerning noradrenergic effects on working memory. Objective The present study aimed at assessing dose-dependent effects of yohimbine, an alpha-2 adrenoceptor antagonist, on working memory performance in healthy humans. We further aimed to explore a potential interactive effect between noradrenergic arousal and lack of control over aversive events on working memory performance. Methods We used a double-blind, fully crossed, placebo-controlled, between-subject design. Participants (N = 121) performed an adaptive n-back task before and after oral administration of either a placebo, 20 mg, or 40 mg yohimbine and a manipulation of controllability, during which participants could either learn to avoid electric shocks (controllability groups), had no instrumental control over shock administration (uncontrollability groups), or did not receive any shocks (no-shock control group). Results While no significant results of noradrenergic stimulation through yohimbine were obtained using conventional frequentist analyses, additional Bayesian analyses provided strong evidence for the absence of an association between pharmacological treatment and working memory performance. We further observed no effect of controllability and no interaction between noradrenergic stimulation and the manipulation of controllability. Conclusions Our results suggest that noradrenergic stimulation through yohimbine does not affect (non-spatial) working memory in healthy human participants.
ISSN:14322072
00333158
DOI:10.1007/s00213-020-05590-0