The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection
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| Název: | The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection |
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| Autoři: | Kyung Sik Kim, Woo Jung Lee, Jin Sub Choi, Sae Byeol Choi, Seung Woo Park |
| Přispěvatelé: | SAE BYEOL CHOI, SEUNG WOO PARK, KYUNG SIK KIM, JIN SUB CHOI, WOO JUNG LEE, Kim, Kyung Sik, Park, Seung Woo, Lee, Woo Jung, Choi, Sae Byeol, Choi, Jin Sub |
| Zdroj: | Journal of Surgical Oncology. 99:335-342 |
| Informace o vydavateli: | Wiley, 2009. |
| Rok vydání: | 2009 |
| Témata: | Male, Bile Duct Neoplasms/mortality, Tumor/blood, Bile Duct Neoplasms/pathology, Duodenal Neoplasms/secondary, Local/diagnosis, bile duct cancer, Disease-Free Survival, Lymph Nodes/pathology, Pancreatic Neoplasms/secondary, R0 resection, 03 medical and health sciences, 0302 clinical medicine, Duodenal Neoplasms, Predictive Value of Tests, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Bilirubin/blood, Aged, Neoplasm Staging, lymph node metastasis, Bilirubin, Middle Aged, Prognosis, Survival Analysis, 3. Good health, Pancreatic Neoplasms, Neoplasm Recurrence, Bile Duct Neoplasms, Lymphatic Metastasis, Multivariate Analysis, Female, Bile Duct Neoplasms/blood, Lymph Nodes, Neoplasm Recurrence, Local, vAged, Biomarkers, Bile Duct Neoplasms/surgery |
| Popis: | Background and ObjectivesThe objective of this study was to analyze the survival outcome and the clinicopathological factors that influence survival and recurrence of middle and distal bile duct cancer after surgical resection.MethodsFrom January 2000 to June 2007, 125 patients underwent surgical resection for middle and distal bile duct cancer. The clinicopathological characteristics and survival outcomes were reviewed retrospectively.ResultsOf the 125 patients, 31 patients underwent segmental resection of the bile duct, and 94 patients underwent pancreaticoduodenectomy (PD). Overall survival rates were 85.8% at 1 year and 38.3% at 5 years. Lymph node metastasis, noncurative resection, poorly differentiated tumor, and preoperative bilirubin level greater than 5.0 mg/dl were significant independent predictors of poor prognosis by multivariate analysis. The number of metastatic lymph nodes did not significantly affect survival. Recurrence occurred in 72 patients (61.0%). Disease‐free survival rates were 74.1% at 1 year and 42.0% at 3 years. Lymph node and distant metastases and poorly differentiated tumors were found to be significant independent predictors of recurrence by multivariate analysis.ConclusionsR0 resection confers a survival benefit, thus the surgeon should make an effort to achieve R0 resection. The presence of lymph node metastasis was a significant prognostic factor. J. Surg. Oncol. 2009;99:335–342. © 2009 Wiley‐Liss, Inc. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | 335~342 |
| Jazyk: | English |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.21238 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/19226533 https://ir.ymlib.yonsei.ac.kr/handle/22282913/103800 https://koreauniv.pure.elsevier.com/en/publications/the-survival-outcome-and-prognostic-factors-for-middle-and-distal http://europepmc.org/abstract/MED/19226533 https://www.ncbi.nlm.nih.gov/pubmed/19226533 https://mdanderson.elsevierpure.com/en/publications/the-survival-outcome-and-prognostic-factors-for-middle-and-distal https://www.onlinelibrary.wiley.com/doi/abs/10.1002/jso.21238 |
| Rights: | Wiley Online Library User Agreement CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....1cd7c2d099455b2f0c188a29a334316a |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background and ObjectivesThe objective of this study was to analyze the survival outcome and the clinicopathological factors that influence survival and recurrence of middle and distal bile duct cancer after surgical resection.MethodsFrom January 2000 to June 2007, 125 patients underwent surgical resection for middle and distal bile duct cancer. The clinicopathological characteristics and survival outcomes were reviewed retrospectively.ResultsOf the 125 patients, 31 patients underwent segmental resection of the bile duct, and 94 patients underwent pancreaticoduodenectomy (PD). Overall survival rates were 85.8% at 1 year and 38.3% at 5 years. Lymph node metastasis, noncurative resection, poorly differentiated tumor, and preoperative bilirubin level greater than 5.0 mg/dl were significant independent predictors of poor prognosis by multivariate analysis. The number of metastatic lymph nodes did not significantly affect survival. Recurrence occurred in 72 patients (61.0%). Disease‐free survival rates were 74.1% at 1 year and 42.0% at 3 years. Lymph node and distant metastases and poorly differentiated tumors were found to be significant independent predictors of recurrence by multivariate analysis.ConclusionsR0 resection confers a survival benefit, thus the surgeon should make an effort to achieve R0 resection. The presence of lymph node metastasis was a significant prognostic factor. J. Surg. Oncol. 2009;99:335–342. © 2009 Wiley‐Liss, Inc. |
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| ISSN: | 10969098 00224790 |
| DOI: | 10.1002/jso.21238 |