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A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats

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Title: A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats
Authors: Coudray, Charles, Fouret, Gilles, Lambert, Karen, Ferreri, Carla, Rieusset, Jennifer, Blachnio-Zabielska, Agnieszka, Lecomte, Jérôme, Ebabe Elle, Raymond, Badia, Eric, Murphy, Michael, Feillet-Coudray, Christine
Contributors: MORNET, Dominique, Dynamique Musculaire et Métabolisme (DMEM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Viale dell'Università, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań (UAM), Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Medical Research Council
Source: British Journal of Nutrition
Publisher Information: Cambridge University Press (CUP), 2016.
Publication Year: 2016
Subject Terms: Male, 0301 basic medicine, Lipids - analysis, IR insulin resistance, Ubiquinone, HFD high-fat diet, Weight Gain, MitoQ, Rats, Sprague-Dawley, Weight gain - drug effects, skeletal - chemistry, Mitochondria - physiology, high-fat, Phospholipids, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Metabolic Syndrome, 2. Zero hunger, 0303 health sciences, PC phosphatidylcholine, S20 - Physiologie de la nutrition humaine, Obesity - metabolism, Glucose intolerance - prevention & control, Fatty Acids, 000 - Autres thèmes, 1. No poverty, Liver - pathology, Organ Size, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Metabolic syndrome, Lipids, Mitochondria, 3. Good health, High-fat diet, Triglycerides - metabolism, Adipose Tissue, Liver, Muscle, Lipid metabolism - drug effects, Fatty acids - analysis, Ubiquinone - pharmacology, Metabolic syndrome - prevention & control, Mitochondria - drug effects, Diet, High-Fat, MitoQ mitochondrial-targeted lipophilic ubiquinone, SM sphingomyelin, 03 medical and health sciences, Phospholipids - analysis, Ubiquinone - analogs & derivatives, Glucose Intolerance, Animals, Obesity, Fatty acids, Muscle, Skeletal, Obesity - etiology, Triglycerides, skeletal - metabolism, Lipid Metabolism, Diet, Rats, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, skeletal - drug effects, DAG diacylglycerol, Organ size - drug effects, Sprague-Dawley, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Adipose tissue - pathology
Description: The prevalence of the metabolic syndrome components including abdominal obesity, dyslipidaemia and insulin resistance is increasing in both developed and developing countries. It is generally accepted that the development of these features is preceded by, or accompanied with, impaired mitochondrial function. The present study was designed to analyse the effects of a mitochondrial-targeted lipophilic ubiquinone (MitoQ) on muscle lipid profile modulation and mitochondrial function in obesogenic diet-fed rats. For this purpose, twenty-four young male Sprague–Dawley rats were divided into three groups and fed one of the following diets: (1) control, (2) high fat (HF) and (3) HF+MitoQ. After 8 weeks, mitochondrial function markers and lipid metabolism/profile modifications in skeletal muscle were measured. The HF diet was effective at inducing the major features of the metabolic syndrome – namely, obesity, hepatic enlargement and glucose intolerance. MitoQ intake prevented the increase in rat body weight, attenuated the increase in adipose tissue and liver weights and partially reversed glucose intolerance. At the muscle level, the HF diet induced moderate TAG accumulation associated with important modifications in the muscle phospholipid classes and in the fatty acid composition of total muscle lipid. These lipid modifications were accompanied with decrease in mitochondrial respiration. MitoQ intake corrected the lipid alterations and restored mitochondrial respiration. These results indicate that MitoQ protected obesogenic diet-fed rats from some features of the metabolic syndrome through its effects on muscle lipid metabolism and mitochondrial activity. These findings suggest that MitoQ is a promising candidate for future human trials in the metabolic syndrome prevention.
Document Type: Article
File Description: text; application/pdf
Language: English
ISSN: 1475-2662
0007-1145
DOI: 10.1017/s0007114515005528
Access URL: https://hal.umontpellier.fr/hal-01804569/file/2016%20Coudray%20et%20al.%2C%20A%20mitochondrial%20targeted.pdf
https://pubmed.ncbi.nlm.nih.gov/26856891
https://pubmed.ncbi.nlm.nih.gov/26856891/
https://hal.umontpellier.fr/hal-01804569/document
https://www.ncbi.nlm.nih.gov/pubmed/26856891
https://hal.archives-ouvertes.fr/hal-01804569
https://agritrop.cirad.fr/580027/
https://europepmc.org/article/MED/26856891
http://agritrop.cirad.fr/580027/
http://agritrop.cirad.fr/580027/1/580027.pdf
Rights: Cambridge Core User Agreement
Accession Number: edsair.doi.dedup.....1cab6940ff7ee784593b23d31877cded
Database: OpenAIRE
Description
Abstract:The prevalence of the metabolic syndrome components including abdominal obesity, dyslipidaemia and insulin resistance is increasing in both developed and developing countries. It is generally accepted that the development of these features is preceded by, or accompanied with, impaired mitochondrial function. The present study was designed to analyse the effects of a mitochondrial-targeted lipophilic ubiquinone (MitoQ) on muscle lipid profile modulation and mitochondrial function in obesogenic diet-fed rats. For this purpose, twenty-four young male Sprague–Dawley rats were divided into three groups and fed one of the following diets: (1) control, (2) high fat (HF) and (3) HF+MitoQ. After 8 weeks, mitochondrial function markers and lipid metabolism/profile modifications in skeletal muscle were measured. The HF diet was effective at inducing the major features of the metabolic syndrome – namely, obesity, hepatic enlargement and glucose intolerance. MitoQ intake prevented the increase in rat body weight, attenuated the increase in adipose tissue and liver weights and partially reversed glucose intolerance. At the muscle level, the HF diet induced moderate TAG accumulation associated with important modifications in the muscle phospholipid classes and in the fatty acid composition of total muscle lipid. These lipid modifications were accompanied with decrease in mitochondrial respiration. MitoQ intake corrected the lipid alterations and restored mitochondrial respiration. These results indicate that MitoQ protected obesogenic diet-fed rats from some features of the metabolic syndrome through its effects on muscle lipid metabolism and mitochondrial activity. These findings suggest that MitoQ is a promising candidate for future human trials in the metabolic syndrome prevention.
ISSN:14752662
00071145
DOI:10.1017/s0007114515005528