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Optimal Effect-Site Concentration of Propofol for Hemodynamic Stability During Intubation with Dexmedetomidine: A Randomized Controlled Study

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Názov: Optimal Effect-Site Concentration of Propofol for Hemodynamic Stability During Intubation with Dexmedetomidine: A Randomized Controlled Study
Autori: Gao H, Wu J, Chen Y, Wang C, Yao M, Yang Y, Miao C, Liang C
Zdroj: Drug Des Devel Ther
Drug Design, Development and Therapy, Vol Volume 19, Pp 3129-3138 (2025)
Informácie o vydavateľovi: Informa UK Limited, 2025.
Rok vydania: 2025
Predmety: Male, Adult, propofol, Dose-Response Relationship, Drug, Adolescent, Hemodynamics, dexmedetomidine, effective concentration, RM1-950, Middle Aged, Young Adult, Clinical Trial Report, Intubation, Intratracheal, Humans, Hypnotics and Sedatives, Female, Therapeutics. Pharmacology, opioid-free anesthesia, Propofol, Dexmedetomidine, endotracheal intubation
Popis: This study aimed to determine the 95% effective concentration (EC95) of propofol via target-controlled infusion (TCI) for endotracheal intubation at three different doses of dexmedetomidine.One hundred and eighty patients aged 18-60 and classified as American Society of Anesthesiologists (ASA) class I-II were enrolled to undergo general anesthesia. Patients were randomly assigned to one of the three groups (A, B, or C), receiving three different doses of dexmedetomidine (0.6, 0.8, or 1 μg/kg) infused over 10 min. Anesthesia was then induced with propofol TCI, followed by rocuronium. The biased coin design method was used to calculate the EC95 of propofol for successful intubation. The primary outcome endpoint was the EC95 of propofol for successful endotracheal intubation at each dexmedetomidine dose.Sixty patients in each group completed the trial. The time from propofol administration to intubation in group C (132.5 ± 10.7 s) was significantly shorter compared to group A (140.2 ± 14.4 s, P
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1177-8881
DOI: 10.2147/dddt.s508736
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40297310
https://doaj.org/article/125029a58c024c9a8aa2cc4da2584ec5
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php).
Prístupové číslo: edsair.doi.dedup.....1c8f4dc430b544e5eeacca4ee8d5184c
Databáza: OpenAIRE
Popis
Abstrakt:This study aimed to determine the 95% effective concentration (EC95) of propofol via target-controlled infusion (TCI) for endotracheal intubation at three different doses of dexmedetomidine.One hundred and eighty patients aged 18-60 and classified as American Society of Anesthesiologists (ASA) class I-II were enrolled to undergo general anesthesia. Patients were randomly assigned to one of the three groups (A, B, or C), receiving three different doses of dexmedetomidine (0.6, 0.8, or 1 μg/kg) infused over 10 min. Anesthesia was then induced with propofol TCI, followed by rocuronium. The biased coin design method was used to calculate the EC95 of propofol for successful intubation. The primary outcome endpoint was the EC95 of propofol for successful endotracheal intubation at each dexmedetomidine dose.Sixty patients in each group completed the trial. The time from propofol administration to intubation in group C (132.5 ± 10.7 s) was significantly shorter compared to group A (140.2 ± 14.4 s, P
ISSN:11778881
DOI:10.2147/dddt.s508736