Hooked on benzodiazepines: GABAA receptor subtypes and addiction
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| Název: | Hooked on benzodiazepines: GABAA receptor subtypes and addiction |
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| Autoři: | Christian Lüscher, Kelly R. Tan, Uwe Rudolph |
| Zdroj: | Trends in Neurosciences, Vol. 34, No 4 (2011) pp. 188-97 Trends in neurosciences |
| Informace o vydavateli: | Elsevier BV, 2011. |
| Rok vydání: | 2011 |
| Témata: | 0301 basic medicine, 616.8, Substance-Related Disorders, Dopamine, Neurons/metabolism, Ventral Tegmental Area/metabolism, Substance-Related Disorders/physiopathology, Benzodiazepines, 03 medical and health sciences, GABA Modulators/adverse effects/metabolism/therapeutic use, Reward, Animals, Humans, Protein Subunits/metabolism, GABA Modulators, Anxiety Disorders/drug therapy, Neurons, 0303 health sciences, Receptors, GABA-A/metabolism, Ventral Tegmental Area, Receptors, GABA-A, Anxiety Disorders, ddc:616.8, Benzodiazepines/adverse effects/metabolism/therapeutic use, 3. Good health, Dopamine/metabolism, Behavior, Addictive, Protein Subunits |
| Popis: | Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment and also for recreational purposes. Within weeks, tolerance to the pharmacological effects can develop as a sign of dependence. In vulnerable individuals with compulsive drug use, addiction will be diagnosed. Here we review recent observations from animal models regarding the cellular and molecular basis that might underlie the addictive properties of benzodiazepines. These data reveal how benzodiazepines, acting through specific GABA(A) receptor subtypes, activate midbrain dopamine neurons, and how this could hijack the mesolimbic reward system. Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 0166-2236 |
| DOI: | 10.1016/j.tins.2011.01.004 |
| Přístupová URL adresa: | https://europepmc.org/articles/pmc4020178?pdf=render https://pubmed.ncbi.nlm.nih.gov/21353710 http://www.cell.com/trends/neurosciences/fulltext/S0166-2236(11)00005-1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020178 http://europepmc.org/articles/PMC4020178 https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(11)00005-1 https://archive-ouverte.unige.ch/unige:26928 http://www.cell.com/trends/neurosciences/abstract/S0166-2236(11)00005-1 https://archive-ouverte.unige.ch/unige:26928 https://doi.org/10.1016/j.tins.2011.01.004 https://archive-ouverte.unige.ch/unige:26928 |
| Rights: | Elsevier TDM |
| Přístupové číslo: | edsair.doi.dedup.....1c1fa50e649cb9c6e7ffa7f29d2fb7da |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment and also for recreational purposes. Within weeks, tolerance to the pharmacological effects can develop as a sign of dependence. In vulnerable individuals with compulsive drug use, addiction will be diagnosed. Here we review recent observations from animal models regarding the cellular and molecular basis that might underlie the addictive properties of benzodiazepines. These data reveal how benzodiazepines, acting through specific GABA(A) receptor subtypes, activate midbrain dopamine neurons, and how this could hijack the mesolimbic reward system. Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability. |
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| ISSN: | 01662236 |
| DOI: | 10.1016/j.tins.2011.01.004 |