Small intestinal microbiota: from taxonomic composition to metabolism
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| Název: | Small intestinal microbiota: from taxonomic composition to metabolism |
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| Autoři: | Simon Yersin, Pascale Vonaesch |
| Zdroj: | Trends in microbiology, vol. 32, no. 10, pp. 970-983 |
| Informace o vydavateli: | Elsevier BV, 2024. |
| Rok vydání: | 2024 |
| Témata: | Humans, Gastrointestinal Microbiome, Bacteria/classification, Bacteria/genetics, Bacteria/metabolism, Intestine, Small/microbiology, Animals, duodenum, ileum, jejunum, nutrient absorption, small intestinal bacterial overgrowth, small intestinal microbiota, Bacteria, Intestine, Small |
| Popis: | The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, the SIM has been poorly characterized due to sampling challenges and ethical considerations. Current evidence suggests that the SIM consists of five core genera and additional segment-specific taxa. These bacteria closely interact with the human host, regulating nutrient absorption and metabolism. Recent work suggests the presence of two forms of small intestinal bacterial overgrowth, one dominated by oral bacteria (SIOBO) and a second dominated by coliform bacteria. Less invasive sampling techniques, omics approaches, and mechanistic studies will allow a more comprehensive understanding of the SIM, paving the way for interventions engineering the SIM towards better health. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 0966-842X |
| DOI: | 10.1016/j.tim.2024.02.013 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38503579 https://serval.unil.ch/notice/serval:BIB_1EAF55E4ABF5 https://serval.unil.ch/resource/serval:BIB_1EAF55E4ABF5.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1EAF55E4ABF51 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....1b713329fec94fec614fa3068a20dd51 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, the SIM has been poorly characterized due to sampling challenges and ethical considerations. Current evidence suggests that the SIM consists of five core genera and additional segment-specific taxa. These bacteria closely interact with the human host, regulating nutrient absorption and metabolism. Recent work suggests the presence of two forms of small intestinal bacterial overgrowth, one dominated by oral bacteria (SIOBO) and a second dominated by coliform bacteria. Less invasive sampling techniques, omics approaches, and mechanistic studies will allow a more comprehensive understanding of the SIM, paving the way for interventions engineering the SIM towards better health. |
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| ISSN: | 0966842X |
| DOI: | 10.1016/j.tim.2024.02.013 |