NADPH-Oxidasen und HIF: zentrale Elemente der Redoxhomöostase
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| Title: | NADPH-Oxidasen und HIF: zentrale Elemente der Redoxhomöostase |
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| Authors: | Agnes Görlach, Andreas Petry |
| Source: | BIOspektrum. 27:142-145 |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Wissenschaft, Life Sciences, general, Biochemistry, general, Human Genetics, Microbiology, Pharmacology/Toxicology, 3. Good health, ddc |
| Description: | Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases are the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact in several ways with hypoxia-inducible transcription factors of the HIF family. This signaling network is active under normoxic and hypoxic conditions as an important regulator of redox homeostasis. Members of the NADPH oxidases-HIF axis appear as interesting therapeutic targets for various disorders characterized by an impaired redox homeostasis. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | German |
| ISSN: | 1868-6249 0947-0867 |
| DOI: | 10.1007/s12268-021-1539-z |
| Access URL: | https://link.springer.com/content/pdf/10.1007/s12268-021-1539-z.pdf https://link.springer.com/content/pdf/10.1007/s12268-021-1539-z.pdf https://link.springer.com/article/10.1007/s12268-021-1539-z https://mediatum.ub.tum.de/1704871 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....1a5673a233e50b36cb477bb931bd1bf6 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases are the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact in several ways with hypoxia-inducible transcription factors of the HIF family. This signaling network is active under normoxic and hypoxic conditions as an important regulator of redox homeostasis. Members of the NADPH oxidases-HIF axis appear as interesting therapeutic targets for various disorders characterized by an impaired redox homeostasis. |
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| ISSN: | 18686249 09470867 |
| DOI: | 10.1007/s12268-021-1539-z |