Comprehensive 4D-flow cardiac magnetic resonance evaluation of the descending thoracic aorta in aortic regurgitation
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| Titel: | Comprehensive 4D-flow cardiac magnetic resonance evaluation of the descending thoracic aorta in aortic regurgitation |
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| Autoren: | J Urmeneta Ulloa, A Álvarez Vázquez, V Martínez de Vega, L Martínez de Vega, C Andreu-Vázquez, I J Thuissard-Vasallo, M Recio Rodríguez, J A Cabrera |
| Quelle: | Eur Heart J Imaging Methods Pract ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) |
| Verlagsinformationen: | Oxford University Press (OUP), 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | Enfermedad cardiovascular, Original Article, Insuficiencia de la Válvula Aórtica, Tecnología médica, Imagen por Resonancia Magnética |
| Beschreibung: | Aims To assess the reproducibility of 4D-Flow cardiac magnetic resonance (CMR) parameters in the descending thoracic aorta—DTAo—(regurgitant fraction [RF], end-diastolic reverse flow [EDRF], and holodiastolic flow reversal [HDR]), and the relationship with RF in the sinotubular junction (STJ), and the left ventricular end-diastolic volume index (LVEDVI) in patients with chronic aortic regurgitation (AR). Methods and results A descriptive study of these variables was conducted. A receiver operating characteristic curve was used to determine the optimal cut-off point. Thirty patients had severe AR (RF ≥ 30%, STJ) and 60 mild-to-moderate (RF < 30%). The mean age was 59 ± 17 years. Left ventricular ejection fraction (LVEF) was 56% (53–61%) and LVEDVI was 94 (76–128) mL/m2. Flow in the DTAo at the left inferior pulmonary vein (LIPV) was easily identifiable and measurements were highly reproducible. The intraclass correlation coefficient was 0.969 (95% CI: 0.954–0.980) for RF and 0.929 (95% CI: 0.893–0.952) for EDRF. Flow parameters measured at the LIPV were all significantly greater in the severe AR group: RF (21% vs. 6%, P < 0.001), EDRF (20 vs. 4 mL/s; P < 0.001), and HDR (20% vs. 8%; P < 0.001). Three parameters—presence of HDR, RF ≥ 17%, and EDRF ≥ 7 mL/s at the LIPV—were associated with RF ≥ 30% in the STJ and elevated LVEDVI. Conclusion 4D-flow CMR can reproducibly assess flow in the DTAo in patients with chronic AR. An RF ≥ 17%, EDRF ≥ 7 mL/s, and/or the presence of HDR in the DTAo (LIPV) were associated with an RF ≥ 30% in STJ and elevated LVEDVI. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 2755-9637 |
| DOI: | 10.1093/ehjimp/qyaf002 |
| Zugangs-URL: | http://hdl.handle.net/11268/14086 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Dokumentencode: | edsair.doi.dedup.....196d8ac8c7460b2325d2fa76c9cd633e |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Aims To assess the reproducibility of 4D-Flow cardiac magnetic resonance (CMR) parameters in the descending thoracic aorta—DTAo—(regurgitant fraction [RF], end-diastolic reverse flow [EDRF], and holodiastolic flow reversal [HDR]), and the relationship with RF in the sinotubular junction (STJ), and the left ventricular end-diastolic volume index (LVEDVI) in patients with chronic aortic regurgitation (AR). Methods and results A descriptive study of these variables was conducted. A receiver operating characteristic curve was used to determine the optimal cut-off point. Thirty patients had severe AR (RF ≥ 30%, STJ) and 60 mild-to-moderate (RF < 30%). The mean age was 59 ± 17 years. Left ventricular ejection fraction (LVEF) was 56% (53–61%) and LVEDVI was 94 (76–128) mL/m2. Flow in the DTAo at the left inferior pulmonary vein (LIPV) was easily identifiable and measurements were highly reproducible. The intraclass correlation coefficient was 0.969 (95% CI: 0.954–0.980) for RF and 0.929 (95% CI: 0.893–0.952) for EDRF. Flow parameters measured at the LIPV were all significantly greater in the severe AR group: RF (21% vs. 6%, P < 0.001), EDRF (20 vs. 4 mL/s; P < 0.001), and HDR (20% vs. 8%; P < 0.001). Three parameters—presence of HDR, RF ≥ 17%, and EDRF ≥ 7 mL/s at the LIPV—were associated with RF ≥ 30% in the STJ and elevated LVEDVI. Conclusion 4D-flow CMR can reproducibly assess flow in the DTAo in patients with chronic AR. An RF ≥ 17%, EDRF ≥ 7 mL/s, and/or the presence of HDR in the DTAo (LIPV) were associated with an RF ≥ 30% in STJ and elevated LVEDVI. |
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| ISSN: | 27559637 |
| DOI: | 10.1093/ehjimp/qyaf002 |