Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells
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| Titel: | Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells |
|---|---|
| Autoren: | Nabetani, Akira, Ishikawa, Fuyuki |
| Weitere Verfasser: | 鍋谷, 彰 |
| Quelle: | Journal of Biochemistry. 149:5-14 |
| Verlagsinformationen: | Oxford University Press (OUP), 2010. |
| Publikationsjahr: | 2010 |
| Schlagwörter: | 0301 basic medicine, Nuclear Proteins/physiology, extrachromosomal telomeric repeat (ECTR), Telomere-Binding Proteins, Cell Cycle Proteins, Telomeric Repeat Binding Protein 2/physiology, PML body, alternative lengthening of telomeres (ALT), Shelterin Complex, DNA-Binding Proteins/physiology, 03 medical and health sciences, Genetic, Telomere-Binding Proteins/physiology, DNA/metabolism, Animals, Humans, Telomeric Repeat Binding Protein 2, Cruciform/metabolism, Telomere/metabolism, Telomerase, Nuclear Proteins/metabolism, Telomere/genetics, Recombination, Genetic, telomere, DNA, Cruciform, MRE11 Homologue Protein, DNA Helicases/physiology, Telomerase/biosynthesis, DNA Helicases, Nuclear Proteins, DNA, Telomere, recombination, Acid Anhydride Hydrolases, 3. Good health, DNA-Binding Proteins, Cell Cycle Proteins/physiology, DNA Repair Enzymes, DNA Repair Enzymes/physiology |
| Beschreibung: | Unlimitedly proliferating cells need to acquire the telomere DNA maintenance mechanism, to counteract possible shortening through multiple rounds of replication and segregation of linear chromosomes. Most human cancer cells express telomerase whereas the other cells utilize the alternative lengthening of telomeres (ALT) pathway to elongate telomere DNA. It is suggested that ALT depends on the recombination between telomere repetitive DNAs. However, the molecular details remain unknown. Recent studies have provided evidence of special structures of telomere DNA and genes essential for the phenotypes of ALT cells. The molecular models of the ALT pathway should be validated to elucidate recombination-mediated telomere maintenance and promote the applications to anti-cancer therapy. |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 0021-924X |
| DOI: | 10.1093/jb/mvq119 |
| Zugangs-URL: | https://academic.oup.com/jb/article-pdf/149/1/5/6443132/mvq119.pdf https://pubmed.ncbi.nlm.nih.gov/20937668 http://ci.nii.ac.jp/naid/10030582554 https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/156369 https://academic.oup.com/jb/article/149/1/5/2182584 http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/156369/1/jb_mvq119.pdf https://academic.oup.com/jb/article-pdf/149/1/5/6443132/mvq119.pdf https://europepmc.org/article/MED/20937668 |
| Dokumentencode: | edsair.doi.dedup.....194b0be4dbba9c6327ed8475ccb385fc |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Unlimitedly proliferating cells need to acquire the telomere DNA maintenance mechanism, to counteract possible shortening through multiple rounds of replication and segregation of linear chromosomes. Most human cancer cells express telomerase whereas the other cells utilize the alternative lengthening of telomeres (ALT) pathway to elongate telomere DNA. It is suggested that ALT depends on the recombination between telomere repetitive DNAs. However, the molecular details remain unknown. Recent studies have provided evidence of special structures of telomere DNA and genes essential for the phenotypes of ALT cells. The molecular models of the ALT pathway should be validated to elucidate recombination-mediated telomere maintenance and promote the applications to anti-cancer therapy. |
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| ISSN: | 0021924X |
| DOI: | 10.1093/jb/mvq119 |