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A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis

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Titel: A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis
Autoren: Jeremy Sousa, John Kim, Apoorva Bhatt, Carlos Magalhães, Henrique Machado, Kiranmai Bhatt, Albel Singh, William R. Jacobs, António G. Castro, Margarida Saraiva, Nuno S. Osório, Egídio Torrado, Bing Chen, Mei Chen, Filipa Cardoso, Catarina Machado Ferreira
Weitere Verfasser: Instituto de Investigação e Inovação em Saúde, Universidade do Minho
Quelle: mSphere
mSphere, Vol 3, Iss 5 (2018)
Verlagsinformationen: American Society for Microbiology, 2018.
Publikationsjahr: 2018
Schlagwörter: 0301 basic medicine, Virulence Factors / genetics, Virulence Factors, Peptide Synthases / metabolismo, Spleen / microbiology, virulence factors, Peptide Synthases / genetics, Mice, SCID, Microbiology, Tuberculosis / microbiology, 03 medical and health sciences, Animals, Tuberculosis, Peptide Synthases, Lung, Virulence, pathogenesis, Mycobacterium tuberculosis / pathogenicity, Virulence Factors / metabolism, Mycobacterium tuberculosis, immune deficiency, Survival Analysis, QR1-502, Bacterial Load, 3. Good health, Mycobacterium tuberculosis / enzymology, Mice, Inbred C57BL, Disease Models, Animal, tuberculosis, Genes, Bacterial, Tuberculosis / pathology, Lung / microbiology, Gene Deletion, Spleen, Research Article
Beschreibung: Over 10 million people developed tuberculosis (TB) in 2016, and over 1.8 million individuals succumbed to the disease. These numbers make TB the ninth leading cause of death worldwide and the leading cause from a single infectious agent. Therefore, finding novel therapeutic targets in Mycobacterium tuberculosis , the pathogen that causes most cases of human TB, is critical. In this study, we reveal a novel virulence factor in M. tuberculosis , the nrp gene. The lack of nrp highly attenuates the course of M. tuberculosis infection in the mouse model, which is particularly relevant in immune-deficient hosts. This is very relevant as TB is particularly incident in immune-suppressed individuals, such as HIV patients.
Publikationsart: Article
Conference object
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 2379-5042
DOI: 10.1128/msphere.00352-18
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30381350
https://doaj.org/article/1ca69f777d56487ab7f418ab4f795bf6
http://repositorium.sdum.uminho.pt/bitstream/1822/58719/1/A%20Nonribosomal%20Peptide%20Synthase%20Gene%20Driving%20Virulence%20in%20Mycobacterium%20tuberculosis.pdf
https://europepmc.org/article/MED/30381350
https://research.birmingham.ac.uk/portal/en/publications/a-nonribosomal-peptide-synthase-gene-driving-virulence-in-mycobacterium-tuberculosis(2b1d78ab-07e8-4707-b18b-3dc7745b2e34).html
https://pubmed.ncbi.nlm.nih.gov/30381350/
https://msphere.asm.org/content/3/5/e00352-18/article-info
https://repositorio-aberto.up.pt/handle/10216/127069
https://hdl.handle.net/10216/127069
https://hdl.handle.net/1822/58719
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....1890c0baefbb45219bd2ac7a2682134f
Datenbank: OpenAIRE
Beschreibung
Abstract:Over 10 million people developed tuberculosis (TB) in 2016, and over 1.8 million individuals succumbed to the disease. These numbers make TB the ninth leading cause of death worldwide and the leading cause from a single infectious agent. Therefore, finding novel therapeutic targets in Mycobacterium tuberculosis , the pathogen that causes most cases of human TB, is critical. In this study, we reveal a novel virulence factor in M. tuberculosis , the nrp gene. The lack of nrp highly attenuates the course of M. tuberculosis infection in the mouse model, which is particularly relevant in immune-deficient hosts. This is very relevant as TB is particularly incident in immune-suppressed individuals, such as HIV patients.
ISSN:23795042
DOI:10.1128/msphere.00352-18