TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression
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| Titel: | TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression |
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| Autoren: | Wasilewski, David, Araceli, Tommaso, Bischoff, Philip, Früh, Anton, Ates, Rober, Murad, Selin, Jung, Niklas, Bukatz, Jan, Samman, Majd, Faust, Katharina, Jünger, Julia, Witzenrath, Martin, Horst, David, Baborie, Atik, Koch, Arend, Capper, David, Heppner, Frank L., Radbruch, Helena, Riemenschneider, Markus J., Schmidt, Nils Ole, Vajkoczy, Peter, Proescholdt, Martin, Onken, Julia, Frost, Nikolaj |
| Quelle: | J Neurooncol |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Research, Disease Progression [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], TTF-1, Adenocarcinoma of Lung/surgery [MeSH], Survival, Male [MeSH], Brain Neoplasms/mortality [MeSH], Brain Metastasis, Ki67, Edema volume, LUAD, Female [MeSH], Lung Neoplasms/mortality [MeSH], Follow-Up Studies [MeSH], Brain Neoplasms/secondary [MeSH], Adult [MeSH], Humans [MeSH], Tumor volume, Retrospective Studies [MeSH], Middle Aged [MeSH], Adenocarcinoma of Lung/metabolism [MeSH], Survival Rate [MeSH], Biomarkers, Tumor/metabolism [MeSH], Adenocarcinoma of Lung/mortality [MeSH], Prognosis [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Adenocarcinoma of Lung/pathology [MeSH], Brain Neoplasms/metabolism [MeSH], Thyroid Nuclear Factor 1/metabolism [MeSH] |
| Beschreibung: | Background Thyroid Transcription Factor-1 (TTF-1) expression in lung adenocarcinoma (LUAD) has been studied for its prognostic value in early-stage and metastatic disease. Its role in brain metastasis remains unexplored. This study investigates the predictive value and association of TTF-1 status with clinicopathological variables in patients with synchronous LUAD brain metastases. Material and methods In this bicentric retrospective study, 245 patients with newly diagnosed, treatment-naïve brain metastasis undergoing resection were included. Patient data were retrieved from electronic records. Outcomes included overall and progression-free survival. Statistical analysis included Kaplan–Meier estimates and Cox proportional hazards regression. Results Mean Ki67 index in TTF-1 negative patients was 43% [95% CI 38–48%] compared to 32% [95% CI 29–35%] in TTF-1 positive (TTF-1 +) patients (p Conclusion In synchronous LUAD brain metastases, TTF-1 negativity reflects an aggressive phenotype with larger proliferation capacity and tumor volume. Future research should explore the underlying cellular and molecular alterations of this phenotype. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-024-04885-y |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39630375 https://repository.publisso.de/resource/frl:6499899 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....184b71197d85f329c528ae15e14d853c |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Thyroid Transcription Factor-1 (TTF-1) expression in lung adenocarcinoma (LUAD) has been studied for its prognostic value in early-stage and metastatic disease. Its role in brain metastasis remains unexplored. This study investigates the predictive value and association of TTF-1 status with clinicopathological variables in patients with synchronous LUAD brain metastases. Material and methods In this bicentric retrospective study, 245 patients with newly diagnosed, treatment-naïve brain metastasis undergoing resection were included. Patient data were retrieved from electronic records. Outcomes included overall and progression-free survival. Statistical analysis included Kaplan–Meier estimates and Cox proportional hazards regression. Results Mean Ki67 index in TTF-1 negative patients was 43% [95% CI 38–48%] compared to 32% [95% CI 29–35%] in TTF-1 positive (TTF-1 +) patients (p Conclusion In synchronous LUAD brain metastases, TTF-1 negativity reflects an aggressive phenotype with larger proliferation capacity and tumor volume. Future research should explore the underlying cellular and molecular alterations of this phenotype. |
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| ISSN: | 15737373 0167594X |
| DOI: | 10.1007/s11060-024-04885-y |