Metabolic signatures of pregnancy-induced cardiac growth
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| Názov: | Metabolic signatures of pregnancy-induced cardiac growth |
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| Autori: | Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins |
| Zdroj: | Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, 'Metabolic Signatures of Pregnancy-Induced Cardiac Growth', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164. https://doi.org/10.1152/ajpheart.00105.2022 |
| Informácie o vydavateľovi: | American Physiological Society, 2022. |
| Rok vydania: | 2022 |
| Predmety: | Proteomics, 0301 basic medicine, Myocardium/metabolism, Myocardium, Cardiomegaly, Heart, Mitochondria, Heart/metabolism, metabolomics, Mitochondria, Heart, 3. Good health, transcriptomics, Mice, 03 medical and health sciences, proteomics, 0302 clinical medicine, Pregnancy, Animals, Cardiomegaly/metabolism, Female, pregnancy, hypertrophy, Oxidation-Reduction |
| Popis: | Little is known of the underlying molecular and cellular mechanisms that contribute to pregnancy-induced cardiac growth. Several lines of evidence suggest that changes in cardiac metabolism may contribute. Here, we provide a comprehensive metabolic atlas of the metabolomic, proteomic, and transcriptomic changes occurring in the maternal heart. We show that pregnancy-induced cardiac growth is associated with changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism. Collectively, these results suggest that substantial metabolic changes occur in the maternal heart during pregnancy and after pregnancy. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00105.2022 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/35622533 https://vbn.aau.dk/da/publications/24d0c8ec-7355-438e-9a4c-52d997c13eee http://www.scopus.com/inward/record.url?scp=85133102678&partnerID=8YFLogxK https://doi.org/10.1152/ajpheart.00105.2022 |
| Prístupové číslo: | edsair.doi.dedup.....1758a83bc043dfdf36a85f3f2f5ea8c6 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Little is known of the underlying molecular and cellular mechanisms that contribute to pregnancy-induced cardiac growth. Several lines of evidence suggest that changes in cardiac metabolism may contribute. Here, we provide a comprehensive metabolic atlas of the metabolomic, proteomic, and transcriptomic changes occurring in the maternal heart. We show that pregnancy-induced cardiac growth is associated with changes in glycerophospholipid, nucleotide, and amino acid metabolism, with reductions in cardiac glucose catabolism. Collectively, these results suggest that substantial metabolic changes occur in the maternal heart during pregnancy and after pregnancy. |
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| ISSN: | 15221539 03636135 |
| DOI: | 10.1152/ajpheart.00105.2022 |