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Comorbidities in childhood atopic dermatitis: A population‐based study

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Název: Comorbidities in childhood atopic dermatitis: A population‐based study
Autoři: Laura von Kobyletzki, Dan Henrohn, Natalia Ballardini, Maureen P. Neary, Gustaf Ortsäter, Alexander Rieem Dun, Kirk Geale, Ingrid Lindberg, Grigorios Theodosiou, Petra Neregård, Anna De Geer, Amy Cha, Joseph C. Cappelleri, Jacob P. Thyssen
Zdroj: von Kobyletzki, L, Henrohn, D, Ballardini, N, Neary, M P, Ortsäter, G, Rieem Dun, A, Geale, K, Lindberg, I, Theodosiou, G, Neregård, P, De Geer, A, Cha, A, Cappelleri, J C & Thyssen, J P 2024, ' Comorbidities in childhood atopic dermatitis : A population-based study ', Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 38, no. 2, pp. 354-364 . https://doi.org/10.1111/jdv.19569
Informace o vydavateli: Wiley, 2023.
Rok vydání: 2023
Témata: Type 1/epidemiology, Dermatitis, Dermatitis, Atopic/complications, Comorbidity, Atopic/complications, 3. Good health, Dermatitis, Atopic, Dermatology and Venereal Diseases, Cohort Studies, Diabetes Mellitus, Type 1, Neoplasms, Diabetes Mellitus, Type 1/epidemiology, Diabetes Mellitus, Humans, Dermatologi och venereologi, Neoplasms/complications, Child
Popis: BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with allergic comorbidities. However, studies examining comorbidities in childhood AD are incomplete, which may contribute to suboptimal care.ObjectiveThe objective was to compare the risk of developing different allergic and non‐allergic comorbidities among children with AD to that of a matched non‐AD reference cohort in Sweden.MethodsThis was a nationwide population‐based cohort study using longitudinal data from primary and specialist care registers. Patients with AD were identified by confirmed diagnosis in primary or specialist care. The non‐AD reference cohort was randomly drawn from the general population and matched 1:1 with the AD patients. The risk of developing the following conditions was evaluated: hypersensitivity and allergic disorders, neurological disorders, psychiatric disorders, infections, immunological and inflammatory disorders, Type 1 diabetes (T1D), endocrine and metabolic disorders, skeletal disorders, ocular disorders and malignancies.ResultsThis study included 165,145 patients with AD (mild‐to‐moderate [n = 126,681] and severe [n = 38,464]) and an equally sized reference cohort. Patients with AD displayed a higher risk of developing comorbid conditions for all investigated categories, except for T1D and skeletal disorders, compared with the reference cohort. The highest risk compared with the reference cohort was observed for hypersensitivity and allergic disorders (hazard ratio [HR]: 3.87), followed by malignancies (HR: 2.53) and immunological and inflammatory disorders (HR: 2.36). Patients with AD also had higher risk of developing multiple comorbidities (≥2). The risk of comorbidity onset increased alongside AD severity and patients with active AD were associated with increased risk of comorbidity onset compared with patients in remission.ConclusionsThe clinical burden of AD is substantial for children with AD and patients are at an increased risk of developing several comorbid conditions extending beyond the atopic march. Our results also showed a positive association between worsening severity of AD and an increased risk of comorbidity onset.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 1468-3083
0926-9959
DOI: 10.1111/jdv.19569
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37824103
https://curis.ku.dk/ws/files/381071331/Acad_Dermatol_Venereol_2023_Kobyletzki_Comorbidities_in_childhood_atopic_dermatitis_A_population_based_study_1_.pdf
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215959
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531483
Rights: CC BY NC
Přístupové číslo: edsair.doi.dedup.....15d068a1c01632110865173ddd27a9ca
Databáze: OpenAIRE
Popis
Abstrakt:BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with allergic comorbidities. However, studies examining comorbidities in childhood AD are incomplete, which may contribute to suboptimal care.ObjectiveThe objective was to compare the risk of developing different allergic and non‐allergic comorbidities among children with AD to that of a matched non‐AD reference cohort in Sweden.MethodsThis was a nationwide population‐based cohort study using longitudinal data from primary and specialist care registers. Patients with AD were identified by confirmed diagnosis in primary or specialist care. The non‐AD reference cohort was randomly drawn from the general population and matched 1:1 with the AD patients. The risk of developing the following conditions was evaluated: hypersensitivity and allergic disorders, neurological disorders, psychiatric disorders, infections, immunological and inflammatory disorders, Type 1 diabetes (T1D), endocrine and metabolic disorders, skeletal disorders, ocular disorders and malignancies.ResultsThis study included 165,145 patients with AD (mild‐to‐moderate [n = 126,681] and severe [n = 38,464]) and an equally sized reference cohort. Patients with AD displayed a higher risk of developing comorbid conditions for all investigated categories, except for T1D and skeletal disorders, compared with the reference cohort. The highest risk compared with the reference cohort was observed for hypersensitivity and allergic disorders (hazard ratio [HR]: 3.87), followed by malignancies (HR: 2.53) and immunological and inflammatory disorders (HR: 2.36). Patients with AD also had higher risk of developing multiple comorbidities (≥2). The risk of comorbidity onset increased alongside AD severity and patients with active AD were associated with increased risk of comorbidity onset compared with patients in remission.ConclusionsThe clinical burden of AD is substantial for children with AD and patients are at an increased risk of developing several comorbid conditions extending beyond the atopic march. Our results also showed a positive association between worsening severity of AD and an increased risk of comorbidity onset.
ISSN:14683083
09269959
DOI:10.1111/jdv.19569