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Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase

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Titel: Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase
Autoren: Jang Dd, Young Bae Kim, Yang Kh, Ki Baik Hahm, Byeongwoo Ahn, Oh Sy, Dae Yong Kim, Ki Taek Nam
Weitere Verfasser: K T Nam, S-Y Oh, D-Y Kim, K-B Hahm, K-H Yang, D D Jang, Y B Kim, B Ahn, Nam, Ki Taek
Quelle: Gut. 53:1250-1255
Verlagsinformationen: BMJ, 2004.
Publikationsjahr: 2004
Schlagwörter: Adenoma, Male, 0301 basic medicine, Knockout, Adenoma/enzymology, Neoplastic/pathology, Nitric Oxide Synthase Type II, Neoplastic/metabolism, Adenocarcinoma, Cell Transformation, Inbred C57BL, Adenocarcinoma/microbiology, Nitric Oxide Synthase/physiology, Helicobacter Infections, Mice, 03 medical and health sciences, Stomach Neoplasms, Helicobacter Infections/complications, Adenoma/microbiology, Animals, Gastric Mucosa/metabolism, Mice, Knockout, Gastritis/microbiology, 0303 health sciences, Adenocarcinoma/pathology, Adenoma/pathology, Helicobacter pylori*/growth & development, Helicobacter pylori, Nitric Oxide Synthase/metabolism, Stomach Neoplasms/enzymology, Stomach Neoplasms/pathology, Stomach, Nitric Oxide Synthase/genetics, Adenocarcinoma/enzymology, Stomach Neoplasms/microbiology, 3. Good health, Gastritis/enzymology, Mice, Inbred C57BL, Tyrosine/analogs & derivatives, Cell Transformation, Neoplastic, Gastric Mucosa, Gastritis, Tyrosine, Tyrosine/metabolism, Nitric Oxide Synthase, Stomach/microbiology, Gastritis/pathology
Beschreibung: Overproduction of nitric oxide via inducible nitric oxide synthase (iNOS) is suggested to be a significant pathogenic factor in Helicobacter pylori induced gastritis. The purpose of this study was to examine the role of iNOS in H pylori associated gastric carcinogenesis.Two types of mice were used in this study: iNOS deficient mice (iNOS-/-) and wild-type littermates. Gastric cancer was generated in mice using a combination treatment comprising N-methyl-N-nitrosourea administration and H pylori infection. Fifty weeks after treatment, tumours in gastric tissues from both types of mice were examined using histopathology, immunohistochemistry, and immunoblotting for iNOS and 3-nitrotyrosine.The overall incidence of gastric cancer at week 50 was significantly lower in iNOS-/- compared with iNOS wild-type mice (p
Publikationsart: Article
Dateibeschreibung: 1250~1255
Sprache: English
ISSN: 0017-5749
DOI: 10.1136/gut.2003.030684
Zugangs-URL: https://gut.bmj.com/content/53/9/1250.full.pdf
https://pubmed.ncbi.nlm.nih.gov/15306579
https://gut.bmj.com/content/gutjnl/53/9/1250.full.pdf
https://gut.bmj.com/content/53/9/1250.full.pdf
https://gut.bmj.com/content/53/9/1250
https://yonsei.pure.elsevier.com/en/publications/decreased-helicobacter-pylori-associated-gastric-carcinogenesis-i
https://europepmc.org/articles/PMC1774181
https://www.ncbi.nlm.nih.gov/pubmed/15306579
Rights: CC BY NC ND
Dokumentencode: edsair.doi.dedup.....15a383e5ce9a258302a16fcdf2ae9b1b
Datenbank: OpenAIRE
Beschreibung
Abstract:Overproduction of nitric oxide via inducible nitric oxide synthase (iNOS) is suggested to be a significant pathogenic factor in Helicobacter pylori induced gastritis. The purpose of this study was to examine the role of iNOS in H pylori associated gastric carcinogenesis.Two types of mice were used in this study: iNOS deficient mice (iNOS-/-) and wild-type littermates. Gastric cancer was generated in mice using a combination treatment comprising N-methyl-N-nitrosourea administration and H pylori infection. Fifty weeks after treatment, tumours in gastric tissues from both types of mice were examined using histopathology, immunohistochemistry, and immunoblotting for iNOS and 3-nitrotyrosine.The overall incidence of gastric cancer at week 50 was significantly lower in iNOS-/- compared with iNOS wild-type mice (p
ISSN:00175749
DOI:10.1136/gut.2003.030684