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Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease

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Názov: Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease
Autori: Damsgaard, Line, Janbek, Janet, Laursen, Thomas M., Høgh, Peter, Vestergaard, Karsten, Gottrup, Hanne, Jensen-Dahm, Christina, Waldemar, Gunhild
Zdroj: Alzheimers Dement
Damsgaard, L, Janbek, J, Laursen, T M, Høgh, P, Vestergaard, K, Gottrup, H, Jensen-Dahm, C & Waldemar, G 2024, 'Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease', Alzheimer's & Dementia, vol. 20, no. 4, pp. 2373-2383. https://doi.org/10.1002/alz.13681
Damsgaard, L, Janbek, J, Laursen, T M, Høgh, P, Vestergaard, K, Gottrup, H, Jensen-Dahm, C & Waldemar, G 2024, ' Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease ', Alzheimer's & Dementia, vol. 20, no. 4, pp. 2373-2383 . https://doi.org/10.1002/alz.13681
Damsgaard, L, Janbek, J, Laursen, T M, Høgh, P, Vestergaard, K, Gottrup, H, Jensen-Dahm, C & Waldemar, G 2024, 'Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease', Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 20, no. 4, pp. 2373-2383. https://doi.org/10.1002/alz.13681
Informácie o vydavateľovi: Wiley, 2024.
Rok vydania: 2024
Predmety: Alzheimer Disease/diagnosis, young onset dementia, early warning signs, morbidity, Alzheimer's disease, registry-based, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Case-Control Studies, Humans, epidemiology, Morbidity, Research Articles, Retrospective Studies
Popis: INTRODUCTIONEarly symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population‐based study aimed to map morbidity prior to YOAD diagnosis.METHODSIn a register‐based incidence density matched nested case‐control study, we examined hospital‐diagnosed morbidity for people diagnosed with YOAD in Danish memory clinics during 2016‐2020 compared to controls in a 10‐year period. Conditional logistic regression produced incidence rate ratios (IRRs).RESULTSThe study included 1745 cases and 5235 controls. YOAD patients had a higher morbidity burden in the year immediately before dementia diagnosis, for certain disorders up to 10 years before. This was especially evident for psychiatric morbidity with the highest increased IRRs throughout the entire period and IRR 1.43 (95% confidence interval 1.14–1.79) in the 5–10‐years before dementia diagnosis.DISCUSSIONYOAD patients display a different pattern of morbidity up to 10 years prior to diagnosis. Awareness of specific alterations in morbidity may improve efforts toward a timely diagnosis.Highlights Retrospective, nested case‐control study of young onset Alzheimer's disease (YOAD). YOAD cases had a higher morbidity burden than controls. YOAD cases had a higher psychiatric morbidity burden up to 10 years before diagnosis. Altered morbidity patterns could serve as an early warning sign of YOAD.
Druh dokumentu: Article
Other literature type
Popis súboru: application/pdf
Jazyk: English
ISSN: 1552-5279
1552-5260
DOI: 10.1002/alz.13681
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38294143
https://vbn.aau.dk/ws/files/703649636/Damsgaard_et_al._2024_._Mapping_morbidity_10_years_prior_to_a_diagnosis_of_young_onset_Alzheimer_s_disease.pdf
http://www.scopus.com/inward/record.url?scp=85183866365&partnerID=8YFLogxK
https://doi.org/10.1002/alz.13681
https://vbn.aau.dk/da/publications/a7dfa993-512b-4839-86eb-d1b83e55ccb0
https://curis.ku.dk/ws/files/391884850/Alzheimer_s_Dementia_2024_Damsgaard_Mapping_morbidity_10_years_prior_to_a_diagnosis_of_young_onset_Alzheimer_s.pdf
http://www.scopus.com/inward/record.url?scp=85183866365&partnerID=8YFLogxK
https://doi.org/10.1002/alz.13681
https://pure.au.dk/portal/en/publications/cad6bdaa-d899-4468-9614-c1de7db405d5
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....14d5fdd7b648bf27a7ed38fceadfc0a2
Databáza: OpenAIRE
Popis
Abstrakt:INTRODUCTIONEarly symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population‐based study aimed to map morbidity prior to YOAD diagnosis.METHODSIn a register‐based incidence density matched nested case‐control study, we examined hospital‐diagnosed morbidity for people diagnosed with YOAD in Danish memory clinics during 2016‐2020 compared to controls in a 10‐year period. Conditional logistic regression produced incidence rate ratios (IRRs).RESULTSThe study included 1745 cases and 5235 controls. YOAD patients had a higher morbidity burden in the year immediately before dementia diagnosis, for certain disorders up to 10 years before. This was especially evident for psychiatric morbidity with the highest increased IRRs throughout the entire period and IRR 1.43 (95% confidence interval 1.14–1.79) in the 5–10‐years before dementia diagnosis.DISCUSSIONYOAD patients display a different pattern of morbidity up to 10 years prior to diagnosis. Awareness of specific alterations in morbidity may improve efforts toward a timely diagnosis.Highlights Retrospective, nested case‐control study of young onset Alzheimer's disease (YOAD). YOAD cases had a higher morbidity burden than controls. YOAD cases had a higher psychiatric morbidity burden up to 10 years before diagnosis. Altered morbidity patterns could serve as an early warning sign of YOAD.
ISSN:15525279
15525260
DOI:10.1002/alz.13681