Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms
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| Titel: | Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms |
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| Autoren: | Wilken, Silvana, Thevathasan, Tharusan, Kamali, Can, Guillot, Adrien, Ihlow, Jana, Fehrenbach, Uli, Danyel, Magdalena, Pratschke, Johann, Tacke, Frank, Krenzien, Felix |
| Quelle: | Clin J Gastroenterol |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2023. |
| Publikationsjahr: | 2023 |
| Schlagwörter: | Adenoma, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Liver, Focal Nodular Hyperplasia, Liver Neoplasms, Humans, Case Report, Focal nodular hyperplasia, Liver/pathology [MeSH], Humans [MeSH], Focal Nodular Hyperplasia/complications [MeSH], Liver Neoplasms/pathology [MeSH], Focal Nodular Hyperplasia/diagnosis [MeSH], Hemangioma/pathology [MeSH], Hepatocellular adenoma, Adenoma/pathology [MeSH], Hemangioma/complications [MeSH], Benign liver tumor, Hepatic hemangioma, Focal Nodular Hyperplasia/pathology [MeSH], Hemangioma |
| Beschreibung: | Simultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1865-7265 1865-7257 |
| DOI: | 10.1007/s12328-023-01899-3 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/38133737 https://repository.publisso.de/resource/frl:6505463 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....146719e20fd08edff03fc282ff3f3652 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Simultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features. |
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| ISSN: | 18657265 18657257 |
| DOI: | 10.1007/s12328-023-01899-3 |