Nonesterified Fatty Acids and Development of Graft Failure in Renal Transplant Recipients
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| Titel: | Nonesterified Fatty Acids and Development of Graft Failure in Renal Transplant Recipients |
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| Autoren: | Klooster, Astrid, Hofker, H. Sijbrand, Navis, Gerjan, Homan van der Heide, Jaap J., Gans, Reinold O. B., van Goor, Harry, Leuvenink, Henri G. D., Bakker, Stephan J. L. |
| Quelle: | Transplantation. 95:1383-1389 |
| Verlagsinformationen: | Ovid Technologies (Wolters Kluwer Health), 2013. |
| Publikationsjahr: | 2013 |
| Schlagwörter: | Adult, Graft Rejection, Male, 0301 basic medicine, Chronic allograft failure, PROTEIN, INDUCED INFLAMMATION, Kaplan-Meier Estimate, Fatty Acids, Nonesterified, DISEASE, Cohort Studies, 03 medical and health sciences, Risk Factors, INJURY, Humans, Transplantation, Homologous, Prospective Studies, Retrospective Studies, Nonesterified fatty acids, DAMAGE, INSULIN-RESISTANCE, Transplantation, BEARING ALBUMIN, Renal transplantation, OLEIC-ACID, Middle Aged, Kidney Transplantation, ALLOGRAFT REJECTION, Proteinuria, PROXIMAL TUBULAR CELL, Regression Analysis, Female, Follow-Up Studies |
| Beschreibung: | Chronic transplant dysfunction is the most common cause of graft failure on the long term. Proteinuria is one of the cardinal clinical signs of chronic transplant dysfunction. Albumin-bound fatty acids (FA) have been hypothesized to be instrumental in the etiology of renal damage induced by proteinuria. We therefore questioned whether high circulating FA could be associated with an increased risk for future development of graft failure in renal transplant recipients (RTR). To this end, we prospectively investigated the association of fasting concentrations of circulating nonesterified FA (NEFA) with the development of graft failure in RTR.Baseline measurements were performed between 2001 and 2003 in outpatient RTR with a functioning graft of more than 1 year. Follow-up was recorded until May 19, 2009. Graft failure was defined as return to dialysis or retransplantation.We included 461 RTR at a median (interquartile range [IQR]) of 6.1 (3.3-11.3) years after transplantation. Median (IQR) fasting concentrations of NEFA were 373 (270-521) μM/L. Median (IQR) follow-up for graft failure beyond baseline was 7.1 (6.1-7.5) years. Graft failure occurred in 23 (15%), 14 (9%), and 9 (6%) of RTR across increasing gender-specific tertiles of NEFA (P=0.04). In a gender-adjusted Cox-regression analysis, log-transformed NEFA level was inversely associated with the development of graft failure (hazard ratio, 0.61; 95% confidence interval, 0.47-0.81; P |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e31828b8f9b |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/23524974 https://research.rug.nl/en/publications/112a9f68-7543-4dab-bf2b-2bc3e39a0a07 https://hdl.handle.net/11370/112a9f68-7543-4dab-bf2b-2bc3e39a0a07 https://doi.org/10.1097/TP.0b013e31828b8f9b https://researchinformation.amsterdamumc.org/en/publications/nonesterified-fatty-acids-and-development-of-graft-failure-in-ren https://www.rug.nl/research/portal/publications/nonesterified-fatty-acids-and-development-of-graft-failure-in-renal-transplant-recipients(112a9f68-7543-4dab-bf2b-2bc3e39a0a07).html https://research.rug.nl/en/publications/nonesterified-fatty-acids-and-development-of-graft-failure-in-ren https://europepmc.org/abstract/MED/23524974 http://www.ncbi.nlm.nih.gov/pubmed/23524974 https://pure.amsterdamumc.nl/en/publications/453835d0-8ccd-438b-b111-8aa9452b6310 https://doi.org/10.1097/TP.0b013e31828b8f9b |
| Dokumentencode: | edsair.doi.dedup.....12fa277ccebd528f45a25d648e7a5309 |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Chronic transplant dysfunction is the most common cause of graft failure on the long term. Proteinuria is one of the cardinal clinical signs of chronic transplant dysfunction. Albumin-bound fatty acids (FA) have been hypothesized to be instrumental in the etiology of renal damage induced by proteinuria. We therefore questioned whether high circulating FA could be associated with an increased risk for future development of graft failure in renal transplant recipients (RTR). To this end, we prospectively investigated the association of fasting concentrations of circulating nonesterified FA (NEFA) with the development of graft failure in RTR.Baseline measurements were performed between 2001 and 2003 in outpatient RTR with a functioning graft of more than 1 year. Follow-up was recorded until May 19, 2009. Graft failure was defined as return to dialysis or retransplantation.We included 461 RTR at a median (interquartile range [IQR]) of 6.1 (3.3-11.3) years after transplantation. Median (IQR) fasting concentrations of NEFA were 373 (270-521) μM/L. Median (IQR) follow-up for graft failure beyond baseline was 7.1 (6.1-7.5) years. Graft failure occurred in 23 (15%), 14 (9%), and 9 (6%) of RTR across increasing gender-specific tertiles of NEFA (P=0.04). In a gender-adjusted Cox-regression analysis, log-transformed NEFA level was inversely associated with the development of graft failure (hazard ratio, 0.61; 95% confidence interval, 0.47-0.81; P |
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| ISSN: | 00411337 |
| DOI: | 10.1097/tp.0b013e31828b8f9b |