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Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?☆

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Bibliographic Details
Title: Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?☆
Authors: Akopian, Aram, Demulder, Anne, Ouriaghli, Frank, Corazza, Francis, Fondu, Pierre, Bergmann, Pierre
Source: Peptides. 21:559-564
Publisher Information: Elsevier BV, 2000.
Publication Year: 2000
Subject Terms: 0301 basic medicine, Bone Resorption -- pathology, Cells, Calcitonin Gene-Related Peptide, Calcitonin Gene-Related Peptide -- antagonists & inhibitors -- pharmacology -- physiology, Disuse osteoporosis, Osteoclasts, Bone Marrow Cells, Paraplegia -- pathology, Colony-Forming Units Assay, 03 medical and health sciences, Osteoclasts -- cytology -- physiology, Ostéologie, Cyclic AMP, Humans, CGRP, Bone Resorption, Cells, Cultured, Paraplegia, 0303 health sciences, Cultured, Granulocyte-Macrophage Colony-Stimulating Factor, Bone Marrow Cells -- cytology -- physiology, Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology, 3. Good health, Cyclic AMP -- metabolism, Osteoclast-like cell, Neurological disorders, Cell Division
Description: Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP.
Document Type: Article
File Description: 1 full-text file(s): application/pdf
Language: English
ISSN: 0196-9781
DOI: 10.1016/s0196-9781(00)00185-6
Access URL: https://pubmed.ncbi.nlm.nih.gov/10822112
https://www.ncbi.nlm.nih.gov/pubmed/10822112
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/127502/Details
https://europepmc.org/abstract/MED/10822112
https://www.sciencedirect.com/science/article/abs/pii/S0196978100001856
Rights: Elsevier TDM
Accession Number: edsair.doi.dedup.....129c82d5ea22471fb596de921c4b3ca6
Database: OpenAIRE
Description
Abstract:Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP.
ISSN:01969781
DOI:10.1016/s0196-9781(00)00185-6