An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo
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| Název: | An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo |
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| Autoři: | Andrada Ianus, Claudia A. M. Wheeler-Kingshott, James Fairney, Mara Cercignani, Rebecca S. Samson, Marco Battiston, Torben Schneider, Sebastien Ourselin, Francesco Grussu, Ferran Prados, Daniel C. Alexander |
| Přispěvatelé: | Battiston, M., Grussu, F., Ianus, A., Schneider, T., Prados, F., Fairney, J., Ourselin, S., Alexander, D. C., Cercignani, M., Gandini, C., Samson, R. S. |
| Zdroj: | Magn Reson Med Magnetic Resonance in Medicine |
| Informace o vydavateli: | Wiley, 2017. |
| Rok vydání: | 2017 |
| Témata: | Adult, Male, quantitative magnetization transfer, Full Papers—Imaging Methodology, 03 medical and health sciences, Computer-Assisted, 0302 clinical medicine, reduced field-of-view, Image Interpretation, Computer-Assisted, Humans, Image Interpretation, Myelin Sheath, spinal cord, Cervical Cord, Signal Processing, Computer-Assisted, R1, Magnetic Resonance Imaging, 3. Good health, Algorithm, myelin, R895, Signal Processing, protocol optimization, Female, Algorithms, Human |
| Popis: | PurposeTo develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time.MethodsA dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field‐of‐view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the Cramer‐Rao‐lower bound. Quantitative model parameters (i.e., bound pool fraction, free and bound pool transverse relaxation times [ , ], and forward exchange rate [kFB]) were estimated implementing a numerical model capable of dealing with the novelties of the sequence adopted. The framework was tested on five healthy subjects.ResultsCramer‐Rao‐lower bound minimization produces optimal sampling schemes without requiring the establishment of a steady‐state MT effect. The proposed framework allows quantitative voxel‐wise estimation of model parameters at the resolution typically used for spinal cord imaging (i.e. 0.75 × 0.75 × 5 mm3), with a protocol duration of ∼35 min. Quantitative magnetization transfer parametric maps agree with literature values. Whole‐cord mean values are: bound pool fraction = 0.11(±0.01), = 46.5(±1.6) ms, = 11.0(±0.2) µs, and kFB = 1.95(±0.06) Hz. Protocol optimization has a beneficial effect on reproducibility, especially for and kFB.ConclusionThe framework developed enables robust characterization of spinal cord microstructure in vivo using qMT. Magn Reson Med 79:2576–2588, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Druh dokumentu: | Article Conference object Other literature type |
| Popis souboru: | application/pdf; STAMPA |
| Jazyk: | English |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.26909 |
| Přístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.26909 https://pubmed.ncbi.nlm.nih.gov/28921614 http://sro.sussex.ac.uk/id/eprint/70392/3/Battiston_et_al-2017-Magnetic_Resonance_in_Medicine.pdf https://orca.cardiff.ac.uk/id/eprint/139550/1/mrm.26909.pdf http://onlinelibrary.wiley.com/doi/10.1002/mrm.26909/full http://sro.sussex.ac.uk/id/eprint/70392/ http://europepmc.org/articles/PMC5836910 https://orca.cf.ac.uk/139550/ https://pubmed.ncbi.nlm.nih.gov/28921614/ https://orca.cardiff.ac.uk/139550/ https://discovery-pp.ucl.ac.uk/id/eprint/1571048/ |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....1229bec7dae3978e73443ce4307d8d09 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | PurposeTo develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time.MethodsA dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field‐of‐view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the Cramer‐Rao‐lower bound. Quantitative model parameters (i.e., bound pool fraction, free and bound pool transverse relaxation times [ , ], and forward exchange rate [kFB]) were estimated implementing a numerical model capable of dealing with the novelties of the sequence adopted. The framework was tested on five healthy subjects.ResultsCramer‐Rao‐lower bound minimization produces optimal sampling schemes without requiring the establishment of a steady‐state MT effect. The proposed framework allows quantitative voxel‐wise estimation of model parameters at the resolution typically used for spinal cord imaging (i.e. 0.75 × 0.75 × 5 mm3), with a protocol duration of ∼35 min. Quantitative magnetization transfer parametric maps agree with literature values. Whole‐cord mean values are: bound pool fraction = 0.11(±0.01), = 46.5(±1.6) ms, = 11.0(±0.2) µs, and kFB = 1.95(±0.06) Hz. Protocol optimization has a beneficial effect on reproducibility, especially for and kFB.ConclusionThe framework developed enables robust characterization of spinal cord microstructure in vivo using qMT. Magn Reson Med 79:2576–2588, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| ISSN: | 15222594 07403194 |
| DOI: | 10.1002/mrm.26909 |