Shape-specific microfabricated particles for biomedical applications: a review
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| Název: | Shape-specific microfabricated particles for biomedical applications: a review |
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| Autoři: | Thomas L. Moore, Alexander B. Cook, Elena Bellotti, Roberto Palomba, Purnima Manghnani, Raffaele Spanò, Sayanti Brahmachari, Martina Di Francesco, Anna Lisa Palange, Daniele Di Mascolo, Paolo Decuzzi |
| Zdroj: | Drug Deliv Transl Res Drug Delivery and Translational Research |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2022. |
| Rok vydání: | 2022 |
| Témata: | Drug Carriers/chemistry, Drug Carriers, Drug Delivery Systems, Polymers/chemistry, SDG 3 - Good Health and Well-being, Polymers, Drug Compounding, Drug Delivery Systems/methods, Original Article, Particle Size, SDG 3 – Goede gezondheid en welzijn, 3. Good health |
| Popis: | The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations. Graphical abstract |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2190-3948 2190-393X |
| DOI: | 10.1007/s13346-022-01143-4 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/35284984 https://hdl.handle.net/11588/950477 https://research.tue.nl/en/publications/f062290b-4ac0-4ad1-9109-aa2465ffbc6d https://doi.org/10.1007/s13346-022-01143-4 https://hdl.handle.net/11589/247700 https://doi.org/10.1007/s13346-022-01143-4 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....1122adc9e90d8e637f3bb4ca03c2e85b |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations. Graphical abstract |
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| ISSN: | 21903948 2190393X |
| DOI: | 10.1007/s13346-022-01143-4 |