The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes
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| Název: | The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes |
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| Autoři: | Lai, KN, Tang, SCW, Leung, JCK, Hicks, PJ, Ho, YW, Chu, DWS, Wong, SSH, Chan, LYY, Leung, VTM, Freedman, BI, Langefeld, CD, Comeau, ME, Bowden, DW, Elbein, SC, Ma, L |
| Zdroj: | Nephrology Dialysis Transplantation. 25:3931-3934 |
| Informace o vydavateli: | Oxford University Press (OUP), 2010. |
| Rok vydání: | 2010 |
| Témata: | Male, 0301 basic medicine, kidney, China, Genotype, type 2 diabetes mellitus, Diabetic Nephropathies - ethnology - etiology - genetics, Polymorphism, Single Nucleotide, 03 medical and health sciences, Japan, Diabetes Mellitus, Single Nucleotide - genetics, Humans, Diabetic Nephropathies, Genetic Predisposition to Disease, Polymorphism, Diabetes Mellitus, Type 2 - complications - ethnology - genetics, Aged, 0303 health sciences, Chinese, diabetic nephropathy, Middle Aged, Acetyl-CoA Carboxylase - genetics, Polymorphism, Single Nucleotide - genetics, United States, 3. Good health, Europe, Diabetes Mellitus, Type 2, Haplotypes, ACACB, Type 2 - complications - ethnology - genetics, Case-Control Studies, Genetic Predisposition to Disease - genetics, Female, Acetyl-CoA Carboxylase |
| Popis: | A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfq303 |
| Přístupová URL adresa: | https://academic.oup.com/ndt/article-pdf/25/12/3931/5274558/gfq303.pdf https://pubmed.ncbi.nlm.nih.gov/20519229 https://pubmed.ncbi.nlm.nih.gov/20519229/ http://europepmc.org/articles/PMC3108368/ https://academic.oup.com/ndt/article-pdf/25/12/3931/5274558/gfq303.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108368/ http://hub.hku.hk/handle/10722/125008 https://paperity.org/p/41553671/the-acetyl-coenzyme-a-carboxylase-beta-acacb-gene-is-associated-with-nephropathy-in http://hdl.handle.net/10722/125008 |
| Přístupové číslo: | edsair.doi.dedup.....10dab6ef0c4ce9e55c0de63c8e85e788 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy. |
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| ISSN: | 14602385 09310509 |
| DOI: | 10.1093/ndt/gfq303 |