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Sarcopenia‐defining parameters, but not sarcopenia, are associated with cognitive domains in middle‐aged and older European men

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Title: Sarcopenia‐defining parameters, but not sarcopenia, are associated with cognitive domains in middle‐aged and older European men
Authors: Amini, Nadjia, Dupont, Jolan, Lapauw, Laurence, Vercauteren, Laura, Antonio, Leen, O'Neill, Terence W.W., Vanderschueren, Dirk, Pendleton, Neil, Rastrelli, Giulia, Maggi, Mario, Casanueva, Felipe F.F., Slowikowska-Hilczer, Jolanta, Punab, Margus, Huhtaniemi, Ilpo T.T., Wu, Frederick C.W., Verschueren, Sabine, Tournoy, Jos, Gielen, Evelien
Source: J Cachexia Sarcopenia Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1520-1532 (2023)
Amini, N, Dupont, J, Lapauw, L, Vercauteren, L, Antonio, L, O'Neill, T W, Vanderschueren, D, Pendleton, N, Rastrelli, G, Maggi, M, Casanueva, F F, Słowikowska-Hilczer, J, Punab, M, Huhtaniemi, I T, Wu, F C W, Verschueren, S, Tournoy, J & Gielen, E 2023, 'Sarcopenia-defining parameters, but not sarcopenia, are associated with cognitive domains in middle-aged and older European men', Journal of cachexia, sarcopenia and muscle, vol. 14, no. 3, pp. 1520-1532. https://doi.org/10.1002/jcsm.13229
Publisher Information: Wiley, 2023.
Publication Year: 2023
Subject Terms: Male, Adult, Sarcopenia, Geriatrics & Gerontology, Sarcopenia/diagnosis, 1106 Human Movement and Sports Sciences, Diseases of the musculoskeletal system, MASS, DISEASE, Physical performance, Cohort Studies, Medicine, General & Internal, Cognition, General & Internal Medicine, STRENGTH, Muscle mass, Muscle strength, Older adults, Humans, Hand Strength/physiology, Cognition/physiology, 4207 Sports science and exercise, Aged, RISK, DECLINE, Science & Technology, Hand Strength, DEMENTIA, QM1-695, 3202 Clinical sciences, 1103 Clinical Sciences, Original Articles, IMPAIRMENT, ta3121, Middle Aged, 0606 Physiology, PREVALENCE, Cross-Sectional Studies, RC925-935, Human anatomy, 4201 Allied health and rehabilitation science, PHYSICAL PERFORMANCE, Life Sciences & Biomedicine
Description: BackgroundPrevious research suggests that sarcopenia is associated with lower cognitive functioning. Evidence on the longitudinal relationship between cognition and sarcopenia, according to the revised criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2), is scarce. This study aimed to investigate both cross‐sectional and longitudinal associations between sarcopenia and its defining parameters (muscle strength, muscle mass and physical performance) and cognitive performance in middle‐aged and older men.MethodsThis was a secondary analysis of data from the European Male Ageing Study (EMAS), a multicentre cohort study of men aged 40–79 years, recruited from population registers in eight European centres. Cognitive functioning was assessed by using a battery of three neuropsychological tests, measuring fluid intelligence: Rey–Osterrieth Complex Figure (ROCF‐Copy and ROCF‐Recall), Camden Topographical Recognition Memory (CTRM) and Digit Symbol Substitution Test (DSST). Sarcopenia‐defining parameters appendicular lean mass (aLM), gait speed (GS), chair stand test (CST) and handgrip strength (HGS) were measured. Sarcopenia was diagnosed according to the criteria of the EWGSOP2. All measurements were performed at baseline and after a follow‐up of 4.3 years. Cross‐sectional associations between cognition, sarcopenia‐defining parameters and prevalent sarcopenia (EWGSOP2) were analysed. Longitudinally, the predictive value of baseline cognition on decline in sarcopenia‐defining parameters, onset of new sarcopenia and vice versa was examined. Linear and logistic regression were used and adjusted for putative confounders.ResultsIn the whole cohort (n = 3233), ROCF‐Copy (β = 0.016; P P P P P n = 456), ROCF‐Copy (β = 1.008; P P P P P P P P P P ConclusionsSarcopenia was not associated with cognitive performance in this population, whereas several components of sarcopenia were associated with domain‐specific cognitive performance. Longitudinally, baseline and change in subdomains of cognition predicted change in muscle function in specific subgroups.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13229
Access URL: https://pubmed.ncbi.nlm.nih.gov/37021434
https://doaj.org/article/2ca32f3b587a4034b55ba734a3f31de4
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Accession Number: edsair.doi.dedup.....0fc8b1115bf4f3bbc2df70e1852ebdc1
Database: OpenAIRE
Description
Abstract:BackgroundPrevious research suggests that sarcopenia is associated with lower cognitive functioning. Evidence on the longitudinal relationship between cognition and sarcopenia, according to the revised criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2), is scarce. This study aimed to investigate both cross‐sectional and longitudinal associations between sarcopenia and its defining parameters (muscle strength, muscle mass and physical performance) and cognitive performance in middle‐aged and older men.MethodsThis was a secondary analysis of data from the European Male Ageing Study (EMAS), a multicentre cohort study of men aged 40–79 years, recruited from population registers in eight European centres. Cognitive functioning was assessed by using a battery of three neuropsychological tests, measuring fluid intelligence: Rey–Osterrieth Complex Figure (ROCF‐Copy and ROCF‐Recall), Camden Topographical Recognition Memory (CTRM) and Digit Symbol Substitution Test (DSST). Sarcopenia‐defining parameters appendicular lean mass (aLM), gait speed (GS), chair stand test (CST) and handgrip strength (HGS) were measured. Sarcopenia was diagnosed according to the criteria of the EWGSOP2. All measurements were performed at baseline and after a follow‐up of 4.3 years. Cross‐sectional associations between cognition, sarcopenia‐defining parameters and prevalent sarcopenia (EWGSOP2) were analysed. Longitudinally, the predictive value of baseline cognition on decline in sarcopenia‐defining parameters, onset of new sarcopenia and vice versa was examined. Linear and logistic regression were used and adjusted for putative confounders.ResultsIn the whole cohort (n = 3233), ROCF‐Copy (β = 0.016; P P P P P n = 456), ROCF‐Copy (β = 1.008; P P P P P P P P P P ConclusionsSarcopenia was not associated with cognitive performance in this population, whereas several components of sarcopenia were associated with domain‐specific cognitive performance. Longitudinally, baseline and change in subdomains of cognition predicted change in muscle function in specific subgroups.
ISSN:21906009
21905991
DOI:10.1002/jcsm.13229