Peritoneal and renal DKK3 clearance in peritoneal dialysis
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| Titel: | Peritoneal and renal DKK3 clearance in peritoneal dialysis |
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| Autoren: | Ehleiter, Hagen, Miranda, Julia, Boes, Dominik, Scheidt, Uta, von Vietinghoff, Sibylle, Schwab, Sebastian |
| Quelle: | BMC Nephrol BMC Nephrology, Vol 25, Iss 1, Pp 1-8 (2024) |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Male, Adult, 0301 basic medicine, Peritoneal dialysis, RAAS blockade, Kidney, Renin-Angiotensin System, 03 medical and health sciences, Adaptor Proteins, Signal Transducing/metabolism [MeSH], Chemokines/metabolism [MeSH], Intercellular Signaling Peptides and Proteins/metabolism [MeSH], Aged [MeSH], Creatinine/metabolism [MeSH], Kidney Failure, Chronic/metabolism [MeSH], Peritoneum/metabolism [MeSH], Male [MeSH], Creatinine/urine [MeSH], Creatinine/blood [MeSH], Chemokines/blood [MeSH], Peritoneal Dialysis [MeSH], Female [MeSH], Adult [MeSH], Biomarkers/blood [MeSH], Kidney/metabolism [MeSH], Humans [MeSH], Middle Aged [MeSH], Dialysis Solutions/metabolism [MeSH], DKK3, Research, Peritoneal Dialysis, Continuous Ambulatory [MeSH], Kidney Failure, Chronic/therapy [MeSH], Renin-Angiotensin System/physiology [MeSH], 0302 clinical medicine, Peritoneal Dialysis, Continuous Ambulatory, Dialysis Solutions, Humans, Adaptor Proteins, Signal Transducing, Aged, Middle Aged, Diseases of the genitourinary system. Urology, 6. Clean water, Creatinine, Intercellular Signaling Peptides and Proteins, Kidney Failure, Chronic, Female, RC870-923, Chemokines, Peritoneum, Peritoneal Dialysis, Biomarkers |
| Beschreibung: | Background Urinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis. Methods DKK3 was assessed in serum, urine and dialysate in a prevalent adult peritoneal dialysis cohort and its concentration analyzed in relation to creatinine and clinical characteristics. Results Highest DKK3 concentrations were found in serum, followed by urine. Dialysate concentrations were significantly lower. Dialysate DKK3 correlated with both other compartments. Serum, dialysate and urine values were stable during three months of follow-up. Continuous ambulatory dialysis (CAPD) but not cycler-assisted peritoneal dialysis (CCPD) volume-dependently increased peritoneal DKK3 in relation to creatinine. RAAS blockade significantly decreased urinary, but not serum or peritoneal DKK3. Conclusion Our data provide a detailed characterization of DKK3 in peritoneal dialysis. They support the notion that the RAAS system is essential for renal DKK3 handling. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/s12882-024-03715-7 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39179976 https://doaj.org/article/c84ed87032474e59a5c909fb23c957b9 https://repository.publisso.de/resource/frl:6505068 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Dokumentencode: | edsair.doi.dedup.....0f418c9f5877065fa2a559844f8f2c39 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Urinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis. Methods DKK3 was assessed in serum, urine and dialysate in a prevalent adult peritoneal dialysis cohort and its concentration analyzed in relation to creatinine and clinical characteristics. Results Highest DKK3 concentrations were found in serum, followed by urine. Dialysate concentrations were significantly lower. Dialysate DKK3 correlated with both other compartments. Serum, dialysate and urine values were stable during three months of follow-up. Continuous ambulatory dialysis (CAPD) but not cycler-assisted peritoneal dialysis (CCPD) volume-dependently increased peritoneal DKK3 in relation to creatinine. RAAS blockade significantly decreased urinary, but not serum or peritoneal DKK3. Conclusion Our data provide a detailed characterization of DKK3 in peritoneal dialysis. They support the notion that the RAAS system is essential for renal DKK3 handling. |
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| ISSN: | 14712369 |
| DOI: | 10.1186/s12882-024-03715-7 |