Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
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| Název: | Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics |
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| Autoři: | Shelby L. Bidwell, Francisco Camara, Anthony J. Cornel, Jared White, Paolo Amedeo, Chunhong Mao, Ryan C. Kennedy, Norman H. Lee, Cédric Feschotte, José M. C. Ribeiro, Marta T Castro, Stephen Higgs, Karyn Megy, George F. Mayhew, Horacio Naveira, Frank H. Collins, Yumin Qi, Akio Mori, Roderic Guigó, Hilary Ranson, Robert M. Waterhouse, Albert J. Vilella, Corey L. Campbell, Jennifer R. Wortman, Jenica L. Abrudan, Robert L. Strausberg, Alexander S. Raikhel, Beatriz García Antelo, Ellen J. Pritham, Sharon R. Hill, Claudio Casola, Ishwar Chandramouliswaran, Charles S. Wondji, Granger G. Sutton, Claire M. Fraser-Liggett, Bruce M. Christensen, Daniel Lawson, Peter Arensburger, Bruce W. Birren, Eric Eisenstadt, David W. Severson, Linda Hannick, Sinéad B. Chapman, Gregory C. Lanzaro, Vishvanath Nene, Clint Howarth, Martin Shumway, Mario Stanke, Bill S. Hansson, Kristin Michel, Scott Christley, Rickard Ignell, Javier Costas, George Dimopoulos, Kathryn S. Campbell, Chinnappa D. Kodira, Neil F. Lobo, Hugh M Roberston, Martin Hammond, Lyric C. Bartholomay, Marc A. T. Muskavitch, Dana L. Vanlandingham, Cheng Sun, Maria F. Unger, Brian J. Haas, Matthew D. Pearson, Evgeny M. Zdobnov, Peter W. Atkinson, Daniela Puiu, Janet Hemingway, Nannan Liu, Elisabet Caler, Owen White, Nam P. Nguyen, Jose M. C. Tubio, Zhijian Jake Tu |
| Přispěvatelé: | Waterhouse, Robert, Nguyen, Nam, Zdobnov, Evgeny, Entomology |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Science, Vol. 330, No 6000 (2010) pp. 86-88 Science (New York N.Y.) |
| Informace o vydavateli: | American Association for the Advancement of Science (AAAS), 2010. |
| Rok vydání: | 2010 |
| Témata: | 576.5, 0301 basic medicine, Anopheles gambiae/genetics, Retroelements, Molecular Sequence Data, Genes, Insect, Receptors, Odorant, Aedes/genetics, Chromosomes, Chromosomes/*genetics, 03 medical and health sciences, Aedes, Anopheles, 11. Sustainability, Animals, ddc:576.5, Genome, Phylogeny, 0303 health sciences, Sequence Analysis, DNA, Receptors, Odorant/genetics, Chromosome Mapping, Genomics, Culex/classification/*genetics/physiology, Parasitic diseases, Insect Vectors, 3. Good health, Culex, Malalties parasitàries, Multigene Family, Insect Proteins/genetics/physiology, DNA Transposable Elements, Insect Proteins, Entomology, Insect Vectors/genetics |
| Popis: | Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major international effort, Arensburger et al. (p. 86 ) uncovered divergences in the C. quinquefasciatus genome compared with the representatives of the other two genera Aedes aegypti and Anopheles gambiae . The main difference noted is the expansion of numbers of genes, particularly for immunity, oxidoreductive functions, and digestive enzymes, which may reflect specific aspects of the Culex life cycle. Bartholomay et al. (p. 88 ) explored infection-response genes in Culex in more depth and uncovered 500 immune response-related genes, similar to the numbers seen in Aedes , but fewer than seen in Anopheles or the fruit fly Drosophila melanogaster . The higher numbers of genes were attributed partly to expansions in those encoding serpins, C-type lectins, and fibrinogen-related proteins, consistent with greater immune surveillance and associated signaling needed to monitor the dangers of breeding in polluted, urbanized environments. Transcriptome analysis confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex . The worm and virus pathogens that the mosquitoes transmit naturally provoked little immune activation, however, suggesting that tolerance has evolved to any damage caused by replication of the pathogens in the insects. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf; p. 86-88 |
| Jazyk: | English |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1191864 |
| Přístupová URL adresa: | https://europepmc.org/articles/pmc3740384?pdf=render https://pubmed.ncbi.nlm.nih.gov/20929810 http://hdl.handle.net/2445/126802 https://hdl.handle.net/2445/126802 http://cgspace.cgiar.org/handle/10568/3419 https://core.ac.uk/display/38935219 https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1143&context=ent_pubs http://europepmc.org/abstract/MED/20929810 https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_513074 http://science.sciencemag.org/content/sci/330/6000/86.full.pdf https://archive-ouverte.unige.ch/unige:20744 |
| Přístupové číslo: | edsair.doi.dedup.....0f0607536697cb55e7ae9866cc9ba156 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major international effort, Arensburger et al. (p. 86 ) uncovered divergences in the C. quinquefasciatus genome compared with the representatives of the other two genera Aedes aegypti and Anopheles gambiae . The main difference noted is the expansion of numbers of genes, particularly for immunity, oxidoreductive functions, and digestive enzymes, which may reflect specific aspects of the Culex life cycle. Bartholomay et al. (p. 88 ) explored infection-response genes in Culex in more depth and uncovered 500 immune response-related genes, similar to the numbers seen in Aedes , but fewer than seen in Anopheles or the fruit fly Drosophila melanogaster . The higher numbers of genes were attributed partly to expansions in those encoding serpins, C-type lectins, and fibrinogen-related proteins, consistent with greater immune surveillance and associated signaling needed to monitor the dangers of breeding in polluted, urbanized environments. Transcriptome analysis confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex . The worm and virus pathogens that the mosquitoes transmit naturally provoked little immune activation, however, suggesting that tolerance has evolved to any damage caused by replication of the pathogens in the insects. |
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| ISSN: | 10959203 00368075 |
| DOI: | 10.1126/science.1191864 |