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Stroma AReactive Invasion Front Areas (SARIFA) predict poor survival in adenocarcinomas of the stomach and gastrooesophageal junction: a validation study

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Název: Stroma AReactive Invasion Front Areas (SARIFA) predict poor survival in adenocarcinomas of the stomach and gastrooesophageal junction: a validation study
Autoři: Dita Ulase, Hans-Michael Behrens, Christoph Röcken
Zdroj: Virchows Arch
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, Aged, 80 and over, Adult, 0301 basic medicine, Esophageal Neoplasms, Gastric cancer, Female [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Stomach Neoplasms/pathology [MeSH], Middle Aged [MeSH], Esophageal Neoplasms/pathology [MeSH], Stomach Neoplasms/mortality [MeSH], Prognosis, Histopathology, Invasive margin, Neoplasm Invasiveness/pathology [MeSH], Original Article, Male [MeSH], Adenocarcinoma/pathology [MeSH], Prognosis [MeSH], Esophageal Neoplasms/mortality [MeSH], Adenocarcinoma/mortality [MeSH], Esophagogastric Junction/pathology [MeSH], Adenocarcinoma, Middle Aged, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Humans, Female, Neoplasm Invasiveness, Esophagogastric Junction, Aged
Popis: Recently, the presence of “Stroma AReactive Invasion Front Areas” (SARIFA) has been described as a promising adverse prognostic factor in gastric cancer. However, the validity of this approach still needs to be tested. The aim of this study was to independently assess the utility of the proposed method in a well-characterised cohort of primary resected adenocarcinomas of stomach and gastrooesophageal junction (n = 392). SARIFA status was analysed on routine slides of resection specimens. Cases were divided into SARIFA-positive and negative groups and analysed in relation to clinicopathological and survival data. SARIFA positivity was found in 15.1% (n = 59) cases and was significantly associated with Lauren phenotype (p < 0.001), pT (p = 0.001), pN (p = 0.018), UICC stage (p = 0.031), tumour budding (p = 0.002), overall survival (p < 0.001) and cancer-specific survival (p < 0.001). SARIFA-positive tumours had a worse prognosis in the multivariate setting (HR = 1.847, 95% CI: 1.300–2.624, p = 0.001). SARIFA status is an independent prognostic factor in gastric cancer, in particular in locally advanced tumours.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-2307
0945-6317
DOI: 10.1007/s00428-024-03826-4
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38748262
https://repository.publisso.de/resource/frl:6521169
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....0de0b5b61eb641cbcd937636bf01372e
Databáze: OpenAIRE
Popis
Abstrakt:Recently, the presence of “Stroma AReactive Invasion Front Areas” (SARIFA) has been described as a promising adverse prognostic factor in gastric cancer. However, the validity of this approach still needs to be tested. The aim of this study was to independently assess the utility of the proposed method in a well-characterised cohort of primary resected adenocarcinomas of stomach and gastrooesophageal junction (n = 392). SARIFA status was analysed on routine slides of resection specimens. Cases were divided into SARIFA-positive and negative groups and analysed in relation to clinicopathological and survival data. SARIFA positivity was found in 15.1% (n = 59) cases and was significantly associated with Lauren phenotype (p < 0.001), pT (p = 0.001), pN (p = 0.018), UICC stage (p = 0.031), tumour budding (p = 0.002), overall survival (p < 0.001) and cancer-specific survival (p < 0.001). SARIFA-positive tumours had a worse prognosis in the multivariate setting (HR = 1.847, 95% CI: 1.300–2.624, p = 0.001). SARIFA status is an independent prognostic factor in gastric cancer, in particular in locally advanced tumours.
ISSN:14322307
09456317
DOI:10.1007/s00428-024-03826-4