Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study
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| Název: | Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study |
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| Autoři: | Patrick Bach, Anne Koopmann, Jan Malte Bumb, Sina Zimmermann, Sina Bühler, Iris Reinhard, Stephanie H. Witt, Marcella Rietschel, Sabine Vollstädt-Klein, Falk Kiefer |
| Zdroj: | Eur Arch Psychiatry Clin Neurosci European Archives of Psychiatry and Clinical Neuroscience |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2020. |
| Rok vydání: | 2020 |
| Témata: | Original Paper, Alcohol Drinking, Emotions, Amygdala, Oxytocin, Magnetic Resonance Imaging, 3. Good health, Facial Expression, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Humans, Amygdala/physiology [MeSH], Double-Blind Method [MeSH], Emotions/physiology [MeSH], Administration, Intranasal [MeSH], Craving, Humans [MeSH], Amygdala/drug effects [MeSH], fMRI, Faces, Magnetic Resonance Imaging [MeSH], Oxytocin/administration, Oxytocin/physiology [MeSH], Emotion, Amygdala/diagnostic imaging [MeSH], Alcohol use disorder, Alcohol Drinking/drug therapy [MeSH], Emotions/drug effects [MeSH], Facial Expression [MeSH], Administration, Intranasal |
| Popis: | IntroductionOxytocin is a key mediator of emotional and social behavior that seems to be of relevance for the development and maintenance of addictive behaviors. We thus investigated the effect of oxytocin on neural response and behavior during a face-matching task in a sample of social drinkers.MethodsThirteen social drinkers underwent a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging face-matching task with and without prior intranasal application of 24 international units oxytocin. Effects of oxytocin and task condition (faces, shapes) on brain activation and individual task performance were assessed.ResultsFace-matching compared to shape-matching trials resulted in higher brain activation in the bilateral amygdala, hippocampus and parts of the occipital gyri. Oxytocin application vs. placebo reduced activation in bilateral amygdala, parts of the frontal gyri, and the parietal lobe. Region of interest analyses indicated that the oxytocin-induced attenuation of amygdala response was specific to face-stimuli and associated with lower subjective alcohol craving, and a lower percentage of heavy-drinking days (defined as ≥ 5 standard drinks/day).ConclusionFor the first time, we could show that a larger oxytocin-induced attenuation of amygdala response to fearful faces is associated with lower subjective craving for alcohol and percentage of heavy drinking days in social drinkers. Modulation of amygdala activation, induced by emotional stimuli, might represent a neurobiological substrate of oxytocin’s protective effects on drug seeking behavior. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1433-8491 0940-1334 |
| DOI: | 10.1007/s00406-020-01115-0 |
| Přístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s00406-020-01115-0.pdf https://pubmed.ncbi.nlm.nih.gov/32076819 https://www.ncbi.nlm.nih.gov/pubmed/32076819 https://link.springer.com/content/pdf/10.1007%2Fs00406-020-01115-0.pdf https://link.springer.com/article/10.1007%2Fs00406-020-01115-0 https://paperity.org/p/233754459/oxytocin-attenuates-neural-response-to-emotional-faces-in-social-drinkers-an-fmri-study https://link.springer.com/article/10.1007/s00406-020-01115-0?error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&code=44fe5bd6-8032-4d1e-92c5-058861bc81d4&code=c2360871-ab04-4e8c-9fef-6760de32688d&code=96bfd238-ee8a-4cfb-b052-b0a6ad180283&code=807146c5-385d-436d-90f6-18f3c20f204b&code=282ef82f-2a05-490e-b832-6b550399733a&code=e0e74174-3483-467f-bced-893082542eff&code=60f2bf3a-cc0d-485a-aaeb-6535b578c5ac&code=fc28ffba-0219-4190-bbe1-758907bc7a89&code=5f9661dd-0e1c-47fc-8941-5be9d9f5b96d&code=1f525d1b-f6e4-4ebc-8617-73995eb03c94&code=f6359c7c-cb29-496e-92a6-fcbe9b579531 https://repository.publisso.de/resource/frl:6467444 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....0cda67c46ff8b24b8393ab27a2f4b8b1 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | IntroductionOxytocin is a key mediator of emotional and social behavior that seems to be of relevance for the development and maintenance of addictive behaviors. We thus investigated the effect of oxytocin on neural response and behavior during a face-matching task in a sample of social drinkers.MethodsThirteen social drinkers underwent a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging face-matching task with and without prior intranasal application of 24 international units oxytocin. Effects of oxytocin and task condition (faces, shapes) on brain activation and individual task performance were assessed.ResultsFace-matching compared to shape-matching trials resulted in higher brain activation in the bilateral amygdala, hippocampus and parts of the occipital gyri. Oxytocin application vs. placebo reduced activation in bilateral amygdala, parts of the frontal gyri, and the parietal lobe. Region of interest analyses indicated that the oxytocin-induced attenuation of amygdala response was specific to face-stimuli and associated with lower subjective alcohol craving, and a lower percentage of heavy-drinking days (defined as ≥ 5 standard drinks/day).ConclusionFor the first time, we could show that a larger oxytocin-induced attenuation of amygdala response to fearful faces is associated with lower subjective craving for alcohol and percentage of heavy drinking days in social drinkers. Modulation of amygdala activation, induced by emotional stimuli, might represent a neurobiological substrate of oxytocin’s protective effects on drug seeking behavior. |
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| ISSN: | 14338491 09401334 |
| DOI: | 10.1007/s00406-020-01115-0 |