Resting-State Amygdala Subregion and Precuneus Connectivity Provide Evidence for a Dimensional Approach to Studying Social Anxiety Disorder
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| Titel: | Resting-State Amygdala Subregion and Precuneus Connectivity Provide Evidence for a Dimensional Approach to Studying Social Anxiety Disorder |
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| Autoren: | Simone Mizzi, Mangor Pedersen, Susan L Rossell, Peter Rendell, Gill Terrett, Markus Heinrichs, Izelle Labuschagne |
| Weitere Verfasser: | Swinburne University of Technology |
| Quelle: | Transl Psychiatry Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024) Translational Psychiatry, 14(1):147 |
| Verlagsinformationen: | Cold Spring Harbor Laboratory, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Phobia, 5202 Biological Psychology, Neurosciences. Biological psychiatry. Neuropsychiatry, Basic Behavioral and Social Science, Article, 1117 Public Health and Health Services, 03 medical and health sciences, Social, 0302 clinical medicine, Clinical Research, Parietal Lobe, Behavioral and Social Science, Humans, Brain Mapping, Neurosciences, 3202 Clinical sciences, Brain, 3 Good Health and Well Being, 1103 Clinical Sciences, Phobia, Social, Amygdala, Anxiety Disorders, Magnetic Resonance Imaging, Brain Disorders, 3. Good health, Mental Health, 1701 Psychology, 52 Psychology, Neurological, 3209 Neurosciences, Parietal Lobe/diagnostic imaging [MeSH], Humans [MeSH], 692/699/476, Brain [MeSH], 59/36, Brain Mapping/methods [MeSH], Amygdala/diagnostic imaging [MeSH], Phobia, Social [MeSH], Anxiety Disorders/diagnostic imaging [MeSH], Magnetic Resonance Imaging/methods [MeSH], 631/378, article, RC321-571 |
| Beschreibung: | BackgroundSocial anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to understand the neurobiological underpinnings of SAD in the absence of threat-related stimuli. Previous studies have primarily focused on the role of the amygdala in SAD. However, the amygdala consists of functionally and structurally distinct subregions, and recent studies have highlighted the importance of investigating the role of these subregions independently.MethodUsing multiband fMRI, we analyzed resting-state data from 135 participants (42 SAD, 93 healthy controls). By employing voxel-wise permutation testing, we examined group differences of fMRI connectivity and associations between fMRI connectivity and social anxiety symptoms to further investigate the classification of SAD as a categorical or dimensional construct.ResultsSeed-to-whole brain functional connectivity analysis using multiple ‘seeds’ including the amygdala and its subregions and the precuneus, revealed no statistically significant group differences. However, social anxiety severity was significantly negatively correlated with functional connectivity of the precuneus - perigenual anterior cingulate cortex and positively correlated with functional connectivity of the amygdala (specifically the superficial subregion) - parietal/cerebellar areas.ConclusionOur findings demonstrate clear links between symptomatology and brain connectivity in the absence of diagnostic differences, with evidence of amygdala subregion-specific alterations. The observed brain-symptom associations did not include disturbances in the brain’s fear circuitry (i.e., disturbances in connectivity between amygdala - prefrontal regions) likely due to the absence of threat-related stimuli. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf; pdf |
| ISSN: | 2158-3188 |
| DOI: | 10.1101/2022.02.27.22271587 |
| DOI: | 10.1038/s41398-024-02844-9 |
| Zugangs-URL: | https://www.medrxiv.org/content/medrxiv/early/2022/02/28/2022.02.27.22271587.full.pdf https://pubmed.ncbi.nlm.nih.gov/38485930 https://doaj.org/article/77089d38d7214f5e803462e75de413f2 https://acuresearchbank.acu.edu.au/item/91x3w/resting-state-amygdala-subregion-and-precuneus-connectivity-provide-evidence-for-a-dimensional-approach-to-studying-social-anxiety-disorder https://repository.publisso.de/resource/frl:6507636 |
| Rights: | CC BY ND CC BY |
| Dokumentencode: | edsair.doi.dedup.....0cb572492f85acfc6a54ee786311d5cd |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | BackgroundSocial anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to understand the neurobiological underpinnings of SAD in the absence of threat-related stimuli. Previous studies have primarily focused on the role of the amygdala in SAD. However, the amygdala consists of functionally and structurally distinct subregions, and recent studies have highlighted the importance of investigating the role of these subregions independently.MethodUsing multiband fMRI, we analyzed resting-state data from 135 participants (42 SAD, 93 healthy controls). By employing voxel-wise permutation testing, we examined group differences of fMRI connectivity and associations between fMRI connectivity and social anxiety symptoms to further investigate the classification of SAD as a categorical or dimensional construct.ResultsSeed-to-whole brain functional connectivity analysis using multiple ‘seeds’ including the amygdala and its subregions and the precuneus, revealed no statistically significant group differences. However, social anxiety severity was significantly negatively correlated with functional connectivity of the precuneus - perigenual anterior cingulate cortex and positively correlated with functional connectivity of the amygdala (specifically the superficial subregion) - parietal/cerebellar areas.ConclusionOur findings demonstrate clear links between symptomatology and brain connectivity in the absence of diagnostic differences, with evidence of amygdala subregion-specific alterations. The observed brain-symptom associations did not include disturbances in the brain’s fear circuitry (i.e., disturbances in connectivity between amygdala - prefrontal regions) likely due to the absence of threat-related stimuli. |
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| ISSN: | 21583188 |
| DOI: | 10.1101/2022.02.27.22271587 |