Sedation and analgesia practices in neonatal intensive care units (EUROPAIN): results from a prospective cohort study
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| Názov: | Sedation and analgesia practices in neonatal intensive care units (EUROPAIN): results from a prospective cohort study |
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| Autori: | Carbajal, Ricardo, Eriksson, Mats, Courtois, Emilie, Boyle, Elaine, Avila-Alvarez, Alejandro, Andersen, Randi Dovland, Sarafidis, Kosmas, Polkki, Tarja, Matos, Cristina, Lago, Paola, Papadouri, Thalia, Montalto, Simon Attard, Ilmoja, Mari-Liis, Simons, Sinno, Tameliene, Rasa, van Overmeire, Bart, Berger, Angelika, Dobrzanska, Anna, Schroth, Michael, Bergqvist, Lena, Lagercrantz, Hugo, Anand, Kanwaljeet J. S., Kiechl-Kohlendorfer, Ursula, Trinkl, Anna, Deindl, Philipp, Wald, Martin, Rigo, Vincent, Dussart, Anneliese, Dierckx, Elke, Coppens, Sophie, Kiilsapaa, Birgit, Metsvaht, Tuuli, Metsäranta, Marjo, Nikolajev, Kari, Saarela, Timo, Peltoniemi, Outi, Tammela, Outi, Lehtonen, Liisa, Savagner, Christophe, Sevestre, Anna, Alexandre, Cénéric, Bouchon-Guedj, Nathalie, Saumureau, Simone, Grosse, Camille, Jouvencel, Philippe, Ramful, Duksha, Clamadieu, Catherine, Mourdie, Julien, Montcho, Yannis, van Kaam, Anton |
| Prispievatelia: | RIGO, Vincent, European Community's Seventh Framework Programme, CE - Commission Européenne, Calvez, Ghislaine, CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Örebro University Hospital Örebro, Sweden, University of Leicester, Complexo Hospitalario Universitario A Coruña (CHUAC). 15006. A Coruña, Telemark Hospital, Neonatal Intensive Care Unit (NICU - THESSALONIKI), Aristotle University of Thessaloniki, Oulu University Central Hospital Finland = Oulun yliopistollinen keskussairaala Suomi = Oulun yliopistollinen sairaala Suomi (OUH, OYKS, OYS), Maternidade Dr Alfredo da Costa (MDrAdC - LISBONNE), Maternidade Dr Alfredo da Costa (MDrAdC), Università degli Studi di Padova = University of Padua (Unipd), Archbishop Makarios Hospital, Mater Dei Hospital, Mater Dei Hospital Malta, Paediatric Intensive Care, Tallinn Children's Hospital, Erasmus University Medical Center Rotterdam (Erasmus MC), Kaunas Perinatal Center (KPC - KAUNAS), Lithuanian University of health Sciences (LSMU), Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis (HUB-ULB), Medizinische Universität Wien = Medical University of Vienna, Children's Memorial Health Institute, Cnopf’sche Kinderklinik, Karolinska Institutet Stockholm, Departments of Woman & Child Health, University of Tennessee Memphis, The University of Tennessee Health Science Center Memphis (UTHSC), Abdus Salam International Centre for Theoretical Physics Trieste (ICTP), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Pédiatrie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest) |
| Zdroj: | The Lancet Respiratory Medicine. 3:796-812 |
| Informácie o vydavateľovi: | Elsevier BV, 2015. |
| Rok vydania: | 2015 |
| Predmety: | Male, MESH: Analgesics, Newborn infants, [SDV]Life Sciences [q-bio], Conscious Sedation, Pediatrics, 0302 clinical medicine, MESH: Hypnotics and Sedatives, Hypnotics and Sedatives/therapeutic use, Neonatal, MESH: Gestational Age, Birth Weight, Hypnotics and Sedatives, Prospective Studies, Human health sciences, Analgesics, Opioid/therapeutic use, Analgesics, Pediatrik, MAC PED, 16. Peace & justice, MESH: Infant, 3. Good health, [SDV] Life Sciences [q-bio], Analgesics, Opioid, Europe, Sedation, Artificial, Technologie de la sécurité, Analgesics/therapeutic use, Female, Respiration, Artificial/statistics & numerical data, Pédiatrie, Midazolam, EMC MM-03-54-04-A, Pain, Respiration, Artificial/methods, Conscious Sedation/statistics & numerical data, Gestational Age, Opioid, Sciences de la santé humaine, Intensive Care Units, Neonatal/statistics & numerical data, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, CPAP, Intensive Care Units, Neonatal, Humans, MESH: Birth Weight, Propensity Score, Conscious Sedation/methods, MESH: Respiration, MESH: Conscious Sedation, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Infant, Newborn, MESH: Propensity Score, Newborn, Respiration, Artificial, MESH: Male, MESH: Prospective Studies, Ventilation, Midazolam/therapeutic use, MESH: Midazolam, MESH: Intensive Care Units, MESH: Europe, Analgesia, MESH: Female |
| Popis: | Neonates who are in pain or are stressed during care in the intensive care unit (ICU) are often given sedation or analgesia. We investigated the current use of sedation or analgesia in neonatal ICUs (NICUs) in European countries.EUROPAIN (EUROpean Pain Audit In Neonates) was a prospective cohort study of the management of sedation and analgesia in patients in NICUs. All neonates admitted to NICUs during 1 month were included in this study. Data on demographics, methods of respiration, use of continuous or intermittent sedation, analgesia, or neuromuscular blockers, pain assessments, and drug withdrawal syndromes were gathered during the first 28 days of admission to NICUs. Multivariable linear regression models and propensity scores were used to assess the association between duration of tracheal ventilation (TV) and exposure to opioids, sedatives-hypnotics, or general anaesthetics in neonates (O-SH-GA). This study is registered with ClinicalTrials.gov, number NCT01694745.From Oct 1, 2012, to June 30, 2013, 6680 neonates were enrolled in 243 NICUs in 18 European countries. Mean gestational age of these neonates was 35.0 weeks (SD 4.6) and birthweight was 2384 g (1007). 2142 (32%) neonates were given TV, 1496 (22%) non-invasive ventilation (NIV), and 3042 (46%) were kept on spontaneous ventilation (SV). 1746 (82%), 266 (18%), and 282 (9%) neonates in the TV, NIV, and SV groups, respectively, were given sedation or analgesia as a continuous infusion, intermittent doses, or both (p |
| Druh dokumentu: | Article |
| Popis súboru: | 1 full-text file(s): application/pdf |
| Jazyk: | English |
| ISSN: | 2213-2600 |
| DOI: | 10.1016/s2213-2600(15)00331-8 |
| Prístupová URL adresa: | http://repositorio.chlc.min-saude.pt/bitstream/10400.17/2573/1/Lancet%20Respir%20Med%202015_796.pdf https://pubmed.ncbi.nlm.nih.gov/26420017 https://pure.eur.nl/en/publications/e78ec560-35a3-4366-8d41-a7a4df593508 https://doi.org/10.1016/S2213-2600(15)00331-8 https://www.sciencedirect.com/science/article/abs/pii/S2213260015003318 https://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(15)00331-8.pdf https://orbi.uliege.be/handle/2268/204566 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(15)00331-8/abstract https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(15)00331-8/fulltext https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/220855/Details https://pure.amsterdamumc.nl/en/publications/f2747c1a-6da9-4fc4-92c8-fd62235423af https://doi.org/10.1016/S2213-2600(15)00331-8 https://hdl.handle.net/2268/204566 https://doi.org/10.1016/S2213-2600(15)00331-8 http://hdl.handle.net/10400.17/2573 https://hal.univ-brest.fr/hal-01559191v1 http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-45921 |
| Rights: | Elsevier TDM |
| Prístupové číslo: | edsair.doi.dedup.....0c05d11272f7b8cdc098bd0686d9879d |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Neonates who are in pain or are stressed during care in the intensive care unit (ICU) are often given sedation or analgesia. We investigated the current use of sedation or analgesia in neonatal ICUs (NICUs) in European countries.EUROPAIN (EUROpean Pain Audit In Neonates) was a prospective cohort study of the management of sedation and analgesia in patients in NICUs. All neonates admitted to NICUs during 1 month were included in this study. Data on demographics, methods of respiration, use of continuous or intermittent sedation, analgesia, or neuromuscular blockers, pain assessments, and drug withdrawal syndromes were gathered during the first 28 days of admission to NICUs. Multivariable linear regression models and propensity scores were used to assess the association between duration of tracheal ventilation (TV) and exposure to opioids, sedatives-hypnotics, or general anaesthetics in neonates (O-SH-GA). This study is registered with ClinicalTrials.gov, number NCT01694745.From Oct 1, 2012, to June 30, 2013, 6680 neonates were enrolled in 243 NICUs in 18 European countries. Mean gestational age of these neonates was 35.0 weeks (SD 4.6) and birthweight was 2384 g (1007). 2142 (32%) neonates were given TV, 1496 (22%) non-invasive ventilation (NIV), and 3042 (46%) were kept on spontaneous ventilation (SV). 1746 (82%), 266 (18%), and 282 (9%) neonates in the TV, NIV, and SV groups, respectively, were given sedation or analgesia as a continuous infusion, intermittent doses, or both (p |
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| ISSN: | 22132600 |
| DOI: | 10.1016/s2213-2600(15)00331-8 |