In EDS ansehen

Prognostic factors of breast cancer and survival in Sub-Saharan Africa: A systematic review and meta-analysis

Gespeichert in:
Bibliographische Detailangaben
Titel: Prognostic factors of breast cancer and survival in Sub-Saharan Africa: A systematic review and meta-analysis
Autoren: Parenté, Alexis, Gnangnon, Freddy, Kinsou, David, Chkeir, Mohamad, Adou, Caroline, Robin Sacca, Hélène, Ivanga, Mahiné, Ngoungou, Edgard, Darré, Tchin, Houinato, Dismand, Preux, Pierre-Marie, Blanquet, Véronique
Weitere Verfasser: Duval, Odile
Quelle: Bulletin du Cancer. 112:1024-1034
Verlagsinformationen: Elsevier BV, 2025.
Publikationsjahr: 2025
Schlagwörter: [SDV] Life Sciences [q-bio], Meta-analysis, Breast cancer, Survival, Sub-Saharan Africa, [SDV.CAN] Life Sciences [q-bio]/Cancer, Epidemiology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Beschreibung: Background > Breast cancer is an escalating public health concern in Sub-Saharan Africa (SSA), where mortality rates remain disproportionately high despite lower incidence compared to Western countries. The combination of late-stage diagnoses, limited healthcare infrastructure, and socioeconomic inequalities severely compromises patient outcomes. Methods > We conducted a systematic review and meta-analysis of 85 studies encompassing 33,053 patients across SSA to characterize breast cancer profiles, focusing on age at diagnosis, cancer stage, molecular subtypes, and survival outcomes. Findings > The mean age at diagnosis was 48.7 years, notably younger than in high-income regions. Half of the patients were diagnosed at stage III, and only 4% at stage I. Luminal A was the most prevalent molecular subtype (30%), followed closely by triple-negative breast cancer (29%), known for its aggressive course and limited treatment options. Survival analysis revealed a pooled 5-year survival rate of 44%, with substantial regional disparities: survival was poorest in West Africa and comparatively better in East Africa and South Africa.
Publikationsart: Article
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 0007-4551
DOI: 10.1016/j.bulcan.2025.05.009
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....0a270ed9643523f1d4d5a9cdd05cf0bf
Datenbank: OpenAIRE
Beschreibung
Abstract:Background > Breast cancer is an escalating public health concern in Sub-Saharan Africa (SSA), where mortality rates remain disproportionately high despite lower incidence compared to Western countries. The combination of late-stage diagnoses, limited healthcare infrastructure, and socioeconomic inequalities severely compromises patient outcomes. Methods > We conducted a systematic review and meta-analysis of 85 studies encompassing 33,053 patients across SSA to characterize breast cancer profiles, focusing on age at diagnosis, cancer stage, molecular subtypes, and survival outcomes. Findings > The mean age at diagnosis was 48.7 years, notably younger than in high-income regions. Half of the patients were diagnosed at stage III, and only 4% at stage I. Luminal A was the most prevalent molecular subtype (30%), followed closely by triple-negative breast cancer (29%), known for its aggressive course and limited treatment options. Survival analysis revealed a pooled 5-year survival rate of 44%, with substantial regional disparities: survival was poorest in West Africa and comparatively better in East Africa and South Africa.
ISSN:00074551
DOI:10.1016/j.bulcan.2025.05.009