Haplotype-resolved genome and population genomics of the threatened garden dormouse in Europe
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| Titel: | Haplotype-resolved genome and population genomics of the threatened garden dormouse in Europe |
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| Autoren: | Byerly, Paige A, von Thaden, Alina, Leushkin, Evgeny, Hilgers, Leon, Liu, Shenglin, Winter, Sven, Schell, Tilman, Gerheim, Charlotte, Ben Hamadou, Alexander, Greve, Carola, Betz, Christian, Bolz, Hanno J, Büchner, Sven, Lang, Johannes, Meinig, Holger, Famira-Parcsetich, Evax Marie, Stubbe, Sarah P, Mouton, Alice, Bertolino, Sandro, Verbeylen, Goedele, Briner, Thomas, Freixas, Lídia, Vinciguerra, Lorenzo, Mueller, Sarah A, Nowak, Carsten, Hiller, Michael |
| Weitere Verfasser: | Federal Agency for Nature Conservation, JLU - Justus Liebig University Giessen |
| Quelle: | Genome Res |
| Verlagsinformationen: | Cold Spring Harbor Laboratory, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | 0301 basic medicine, 0303 health sciences, Genome, Endangered Species, Genetic Variation, Genomics, Life sciences, Resources, Genomics/methods, Europe, Zoologie, 03 medical and health sciences, Genetics, Population, Haplotypes, Genetics, Sciences du vivant, Animals, Zoology, Genetics (clinical) |
| Beschreibung: | Genomic resources are important for evaluating genetic diversity and supporting conservation efforts. The garden dormouse (Eliomys quercinus) is a small rodent that has experienced one of the most severe modern population declines in Europe. We present a high-quality haplotype-resolved reference genome for the garden dormouse, and combine comprehensive short and long-read transcriptomics data sets with homology-based methods to generate a highly complete gene annotation. Demographic history analysis of the genome reveal a sharp population decline since the last interglacial, indicating an association between colder climates and population declines before anthropogenic influence. Using our genome and genetic data from 100 individuals, largely sampled in a citizen-science project across the contemporary range, we conduct the first population genomic analysis for this species. We find clear evidence for population structure across the species’ core Central European range. Notably, our data show that the Alpine population, characterized by strong differentiation and reduced genetic diversity, is reproductively isolated from other regions and likely represents a differentiated evolutionary significant unit (ESU). The predominantly declining Eastern European populations also show signs of recent isolation, a pattern consistent with a range expansion from Western to Eastern Europe during the Holocene, leaving relict populations now facing local extinction. Overall, our findings suggest that garden dormouse conservation may be enhanced in Europe through the designation of ESUs. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1549-5469 1088-9051 |
| DOI: | 10.1101/gr.279066.124 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39542649 https://hdl.handle.net/2268/331026 https://doi.org/10.1101/gr.279066.124 |
| Rights: | URL: http://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) . |
| Dokumentencode: | edsair.doi.dedup.....0994a5f2e9ce3703004c5e8355effe7a |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Genomic resources are important for evaluating genetic diversity and supporting conservation efforts. The garden dormouse (Eliomys quercinus) is a small rodent that has experienced one of the most severe modern population declines in Europe. We present a high-quality haplotype-resolved reference genome for the garden dormouse, and combine comprehensive short and long-read transcriptomics data sets with homology-based methods to generate a highly complete gene annotation. Demographic history analysis of the genome reveal a sharp population decline since the last interglacial, indicating an association between colder climates and population declines before anthropogenic influence. Using our genome and genetic data from 100 individuals, largely sampled in a citizen-science project across the contemporary range, we conduct the first population genomic analysis for this species. We find clear evidence for population structure across the species’ core Central European range. Notably, our data show that the Alpine population, characterized by strong differentiation and reduced genetic diversity, is reproductively isolated from other regions and likely represents a differentiated evolutionary significant unit (ESU). The predominantly declining Eastern European populations also show signs of recent isolation, a pattern consistent with a range expansion from Western to Eastern Europe during the Holocene, leaving relict populations now facing local extinction. Overall, our findings suggest that garden dormouse conservation may be enhanced in Europe through the designation of ESUs. |
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| ISSN: | 15495469 10889051 |
| DOI: | 10.1101/gr.279066.124 |