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Thermo-responsive magnetic Fe 3 O 4 @P(MEO 2 MA X -OEGMA 100-X ) NPs and their applications as drug delivery systems

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Bibliographic Details
Title: Thermo-responsive magnetic Fe 3 O 4 @P(MEO 2 MA X -OEGMA 100-X ) NPs and their applications as drug delivery systems
Authors: Joumana Toufaily, Raphaël Schneider, Eric Gaffet, Jaafar Ghanbaja, Halima Alem, Abdelaziz Meftah, Thibault Roques-Carmes, Zied Ferjaoui, Sophie Marchal, Enaam Jamal Al Dine, Tayssir Hamieh
Source: International Journal of Pharmaceutics. 532:738-747
Publisher Information: Elsevier BV, 2017.
Publication Year: 2017
Subject Terms: Cell Survival, Antineoplastic Agents chemistry, Antineoplastic Agents, 02 engineering and technology, Polyethylene Glycols administration & dosage, 01 natural sciences, Polyethylene Glycols, Magnetite Nanoparticles chemistry, Drug Delivery Systems, Polyethylene Glycols chemistry, Polymethacrylic Acids, Polymethacrylic Acids chemistry, Antineoplastic Agents administration & dosage, Humans, Magnetite Nanoparticles administration & dosage, Magnetite Nanoparticles, Doxorubicin administration & dosage, Doxorubicin chemistry, Polymethacrylic Acids administration & dosage, Temperature, 0104 chemical sciences, 3. Good health, Drug Liberation, Doxorubicin, Cell Survival drug effects, 0210 nano-technology, HT29 Cells
Description: The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range. The core/shell NPs were first synthesized and their chemical, physical, magnetic and thermo-responsive properties where fully characterized in a second step. The lower critical solution temperature (LCST) of the core/shell NPs was tuned in physiological media in order to release the cancer drug at a controlled temperature slightly above the body temperature to avoid any premature release of the drug. The core/shell NPs exhibiting the targeted LCST were then loaded with Doxurubicin (DOX) and the drug release properties were then studied with the temperature. Moreover the cytotoxicity tests have shown that the core/shell NPs had a very limited cytotoxicity up to concentration of 25μg/mL. This investigation showed that the significant release occurred at the targeted temperature in the physiological media making those nano-systems very promising for further use in drug delivery platform.
Document Type: Article
Language: English
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2017.09.019
Access URL: https://pubmed.ncbi.nlm.nih.gov/28893585
https://cris.maastrichtuniversity.nl/en/publications/67e1f223-ab10-405b-b501-3b5b17ffac79
https://doi.org/10.1016/j.ijpharm.2017.09.019
https://europepmc.org/article/MED/28893585
https://www.sciencedirect.com/science/article/pii/S0378517317308748
https://www.ncbi.nlm.nih.gov/pubmed/28893585
https://hal.archives-ouvertes.fr/hal-01650405
Rights: Elsevier TDM
Accession Number: edsair.doi.dedup.....06829c8a9f85c4036af6a51d92abc07d
Database: OpenAIRE
Description
Abstract:The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range. The core/shell NPs were first synthesized and their chemical, physical, magnetic and thermo-responsive properties where fully characterized in a second step. The lower critical solution temperature (LCST) of the core/shell NPs was tuned in physiological media in order to release the cancer drug at a controlled temperature slightly above the body temperature to avoid any premature release of the drug. The core/shell NPs exhibiting the targeted LCST were then loaded with Doxurubicin (DOX) and the drug release properties were then studied with the temperature. Moreover the cytotoxicity tests have shown that the core/shell NPs had a very limited cytotoxicity up to concentration of 25μg/mL. This investigation showed that the significant release occurred at the targeted temperature in the physiological media making those nano-systems very promising for further use in drug delivery platform.
ISSN:03785173
DOI:10.1016/j.ijpharm.2017.09.019