Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies
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| Název: | Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies |
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| Autoři: | Doreen L. Lemmen, Ruben P. A. van Eijk, Jordi W. J. van Unnik, Jeffrey A. Allen, Yusuf A. Rajabally, Leonard H. van den Berg, W. Ludo van der Pol, H. Stephan Goedee |
| Přispěvatelé: | Projectafdeling ALS, Brain, Neurologen |
| Zdroj: | J Peripher Nerv Syst |
| Informace o vydavateli: | Wiley, 2025. |
| Rok vydání: | 2025 |
| Témata: | Research Report, Male, Adult, Hand Strength, Reproducibility of Results, Middle Aged, Mobile Applications, Mobile Applications/standards, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis, Journal Article, Humans, Feasibility Studies, Female, Hand Strength/physiology, Patient Reported Outcome Measures, Aged, Follow-Up Studies |
| Popis: | Background and AimsMultifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP) are immune‐mediated neuropathies characterized by muscle weakness and/or sensory deficits. Identifying treatment response, relapse, and stability can be challenging in these chronic, sometimes unpredictable, conditions. This study explores the potential of a monitoring app designed to address these challenges.MethodsPatients were monitored weekly or monthly, based on stability and patient preference, using grip strength, modified timed‐up‐and go (mTUG), and patient‐reported outcome measures (PROMs). User experience was evaluated via a questionnaire addressing content and ease of use (scale 0–10). Adherence was measured as the percentage of completed mandatory assessments. We investigated reliability using intra‐class correlation coefficients (ICCs) and standard errors of the mean (SEM) of repeated measurements. Longitudinal changes were analyzed using linear mixed‐effects models.ResultsWe included 38 patients, with a mean follow‐up of 11 months (IQR 4.6–19.5). The mean user experience score was 8.35/10 (range 7–10). Adherence was 93% (95% CI: 91.9%–94.1%). Reported remote measurements for grip strength were 1358/1468 (93%), and 1343/1430 (94%) for mTUG. Grip strength and mTUG ICCs were both 0.96 (95% CI: 0.93–0.98 and 0.92–0.99, respectively). The average SEM was 8.46% (95% CI: 6.58–10.28) for grip strength and 8.18% (95% CI: 6.12–10.41) for mTUG. Only grip strength changed significantly, increasing by 3.1 pounds per 6 months (95% CI: 0.61–5.83; p = 0.016).InterpretationOur study demonstrates that tele‐neuromonitoring is feasible and reliable, showing high adherence, positive user experience and high ICCs. We anticipate tele‐neuromonitoring could complement routine follow‐up, enabling clinicians to make better‐informed treatment decisions. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1529-8027 1085-9489 |
| DOI: | 10.1111/jns.70005 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40099640 https://dspace.library.uu.nl/handle/1874/461012 |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| Přístupové číslo: | edsair.doi.dedup.....05cf1ed5466d9ab4a3b50fcabe70081a |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background and AimsMultifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP) are immune‐mediated neuropathies characterized by muscle weakness and/or sensory deficits. Identifying treatment response, relapse, and stability can be challenging in these chronic, sometimes unpredictable, conditions. This study explores the potential of a monitoring app designed to address these challenges.MethodsPatients were monitored weekly or monthly, based on stability and patient preference, using grip strength, modified timed‐up‐and go (mTUG), and patient‐reported outcome measures (PROMs). User experience was evaluated via a questionnaire addressing content and ease of use (scale 0–10). Adherence was measured as the percentage of completed mandatory assessments. We investigated reliability using intra‐class correlation coefficients (ICCs) and standard errors of the mean (SEM) of repeated measurements. Longitudinal changes were analyzed using linear mixed‐effects models.ResultsWe included 38 patients, with a mean follow‐up of 11 months (IQR 4.6–19.5). The mean user experience score was 8.35/10 (range 7–10). Adherence was 93% (95% CI: 91.9%–94.1%). Reported remote measurements for grip strength were 1358/1468 (93%), and 1343/1430 (94%) for mTUG. Grip strength and mTUG ICCs were both 0.96 (95% CI: 0.93–0.98 and 0.92–0.99, respectively). The average SEM was 8.46% (95% CI: 6.58–10.28) for grip strength and 8.18% (95% CI: 6.12–10.41) for mTUG. Only grip strength changed significantly, increasing by 3.1 pounds per 6 months (95% CI: 0.61–5.83; p = 0.016).InterpretationOur study demonstrates that tele‐neuromonitoring is feasible and reliable, showing high adherence, positive user experience and high ICCs. We anticipate tele‐neuromonitoring could complement routine follow‐up, enabling clinicians to make better‐informed treatment decisions. |
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| ISSN: | 15298027 10859489 |
| DOI: | 10.1111/jns.70005 |