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Combination of red blood cell distribution width and platelet-to-lymphocyte ratio for predicting severity of diabetic retinopathy

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Titel: Combination of red blood cell distribution width and platelet-to-lymphocyte ratio for predicting severity of diabetic retinopathy
Autoren: Zhi-Mei Wei, Yu Zhao, Ran-Ran Ding, Yu-Song Zeng, Zheng Zeng, Zi-Tong He, Jing Hao, Jing-Jing Hu, Jin-Guo Yu, Cai-Yun You
Quelle: International Journal of Ophthalmology, Vol 18, Iss 8, Pp 1506-1514 (2025)
Verlagsinformationen: Press of International Journal of Ophthalmology (IJO Press), 2025.
Publikationsjahr: 2025
Schlagwörter: diabetic retinopathy, Ophthalmology, systemic inflammation index, red blood cell distribution width, RE1-994, neutrophil-lymphocyte ratio, platelet-to-lymphocyte ratio, national health and nutrition examination survey (nhanes) database
Beschreibung: AIM: To assess and compare the utility of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), and red blood cell distribution width (RDW) as potential biomarkers to predict the severity of diabetic retinopathy (DR) in the United States population. METHODS: The observational study enlisted patients diagnosed with DR from the National Health and Nutrition Examination Survey (NHANES) database, spanning the period from 2005 to 2008. The severity of DR was defined according to Early Treatment for Diabetic Retinopathy Study (ETDRs). The effect of NLR, PLR, SII, and RDW on proliferative diabetic retinopathy (PDR) were explored using multivariable logistic regression analysis model. Subgroup analysis and restricted cubic splines (RCS) were conducted to assess the robustness of the correlations across subgroups and to explore nonlinear relationships between four indices and PDR. The receiver operating characteristic (ROC) analysis was employed for the purpose of assessing and evaluating the predictive efficacy of NLR, PLR, SII, and RDW in determining the severity of DR. RESULTS: After adjusting for other confounders (age, gender, race, body mass index, diabetes duration, and HbA1c) in multivariable analysis, a unit increase of PLR×0.1, SII×0.01, and RDW would raise the risk for PDR by 15.6%, 22.2%, and 33%, respectively. Particularly, there was a 2.208-fold greater risk of PDR in individuals with an elevated NLR (OR=2.208, 95%CI, 1.348-3.617, P
Publikationsart: Article
ISSN: 2227-4898
2222-3959
DOI: 10.18240/ijo.2025.08.12
Zugangs-URL: https://doaj.org/article/5b690159accd4a308bf136fff7c30896
Dokumentencode: edsair.doi.dedup.....05c607ad9f3093d27113fa97012e097c
Datenbank: OpenAIRE
Beschreibung
Abstract:AIM: To assess and compare the utility of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), and red blood cell distribution width (RDW) as potential biomarkers to predict the severity of diabetic retinopathy (DR) in the United States population. METHODS: The observational study enlisted patients diagnosed with DR from the National Health and Nutrition Examination Survey (NHANES) database, spanning the period from 2005 to 2008. The severity of DR was defined according to Early Treatment for Diabetic Retinopathy Study (ETDRs). The effect of NLR, PLR, SII, and RDW on proliferative diabetic retinopathy (PDR) were explored using multivariable logistic regression analysis model. Subgroup analysis and restricted cubic splines (RCS) were conducted to assess the robustness of the correlations across subgroups and to explore nonlinear relationships between four indices and PDR. The receiver operating characteristic (ROC) analysis was employed for the purpose of assessing and evaluating the predictive efficacy of NLR, PLR, SII, and RDW in determining the severity of DR. RESULTS: After adjusting for other confounders (age, gender, race, body mass index, diabetes duration, and HbA1c) in multivariable analysis, a unit increase of PLR×0.1, SII×0.01, and RDW would raise the risk for PDR by 15.6%, 22.2%, and 33%, respectively. Particularly, there was a 2.208-fold greater risk of PDR in individuals with an elevated NLR (OR=2.208, 95%CI, 1.348-3.617, P
ISSN:22274898
22223959
DOI:10.18240/ijo.2025.08.12