View in EDS

Working Up Donors for High-Urgency and Elective Adult-To-Adult Live Donor Liver Transplantation†

Saved in:
Bibliographic Details
Title: Working Up Donors for High-Urgency and Elective Adult-To-Adult Live Donor Liver Transplantation†
Authors: Chan, SC, Liu, CL, Lee, EW, Fan, ST, Lam, BK, Lo, CM
Source: Liver Transplantation. 13:509-515
Publisher Information: Ovid Technologies (Wolters Kluwer Health), 2007.
Publication Year: 2007
Subject Terms: Adult, Male, Surgical Procedures, Informed Consent, Adolescent, Liver Transplantation - statistics and numerical data, Living Donors - psychology, Middle Aged, Liver Transplantation, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Elective, Elective Surgical Procedures, Surgical Procedures, Elective, Living Donors, Humans, Family, Female, Spouses
Description: Abstract Donor workup for adult-to-adult live donor liver transplantation is done to ensure that the donor remains physically and psychologically healthy after saving or improving the life of the recipient. Even though two-thirds of the liver transplants in our center were from live donors, this life-saving procedure remains a mere treatment option, given the magnitude of the donor operation with the associated donor risks. Live donor liver transplantation was also adopted for high-urgency situations provided that the donor was suitable and the recipient considered salvageable. Donor workup in this setting had not been reported in the literature. In this cohort of 399 potential donors, 128 (32.1%) ultimately underwent donor surgery. Donors in the high-urgency situation had a lower operation rate of 28.4% (64/225) compared with that of 36.8% (64/174) of donors in the elective situation (P = 0.049). Dropouts from step 1 mainly because of ABO incompatibility, positive hepatitis serology, comorbidities, and voluntary donor withdrawal were 52.6% (210/399). Only 11.6% (22/189) of the potential donors who proceeded to subsequent steps of the workup dropped out (2 were psychologically unsuitable, 10 were anatomically prohibitive). The transplantation rate of potential recipients with 1 or more potential donors was also high. The rates were similar for the high-urgency (55%, 64/116) and the elective (51%, 64/125) situations. In a region with scarcity of deceased donor liver grafts, careful and expeditious initial donor workup minimizes dropouts from subsequent steps and allows timely transplantation in high-urgency situations. Liver Transpl 13:509–515, 2007. © 2007 AASLD.
Document Type: Article
Language: English
ISSN: 1527-6465
DOI: 10.1002/lt.21029
Access URL: https://pubmed.ncbi.nlm.nih.gov/17394148
https://www.ncbi.nlm.nih.gov/pubmed/17394148
https://core.ac.uk/display/37912853
https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.21029
https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.21029
http://onlinelibrary.wiley.com/doi/10.1002/lt.21029/abstract
https://www.medpagetoday.com/upload/2007/4/4/Livtrans.pdf
http://hdl.handle.net/10722/83492
Rights: Wiley TDM
Accession Number: edsair.doi.dedup.....04ad9c2fa41fedfdf97f962ee9acf6c1
Database: OpenAIRE
Description
Abstract:Abstract Donor workup for adult-to-adult live donor liver transplantation is done to ensure that the donor remains physically and psychologically healthy after saving or improving the life of the recipient. Even though two-thirds of the liver transplants in our center were from live donors, this life-saving procedure remains a mere treatment option, given the magnitude of the donor operation with the associated donor risks. Live donor liver transplantation was also adopted for high-urgency situations provided that the donor was suitable and the recipient considered salvageable. Donor workup in this setting had not been reported in the literature. In this cohort of 399 potential donors, 128 (32.1%) ultimately underwent donor surgery. Donors in the high-urgency situation had a lower operation rate of 28.4% (64/225) compared with that of 36.8% (64/174) of donors in the elective situation (P = 0.049). Dropouts from step 1 mainly because of ABO incompatibility, positive hepatitis serology, comorbidities, and voluntary donor withdrawal were 52.6% (210/399). Only 11.6% (22/189) of the potential donors who proceeded to subsequent steps of the workup dropped out (2 were psychologically unsuitable, 10 were anatomically prohibitive). The transplantation rate of potential recipients with 1 or more potential donors was also high. The rates were similar for the high-urgency (55%, 64/116) and the elective (51%, 64/125) situations. In a region with scarcity of deceased donor liver grafts, careful and expeditious initial donor workup minimizes dropouts from subsequent steps and allows timely transplantation in high-urgency situations. Liver Transpl 13:509–515, 2007. © 2007 AASLD.
ISSN:15276465
DOI:10.1002/lt.21029