Altered Structure-Function Coupling Associated with Attention Decline in Shift Work Disorder
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| Názov: | Altered Structure-Function Coupling Associated with Attention Decline in Shift Work Disorder |
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| Autori: | Ziyao Wu, Sitong Feng, Kuangshi Li, Linrui Dong, Liang Zhang, Yanzhe Ning, Dongqing Yin |
| Zdroj: | Nat Sci Sleep Nature and Science of Sleep, Vol Volume 17, Iss Issue 1, Pp 989-1001 (2025) |
| Informácie o vydavateľovi: | Informa UK Limited, 2025. |
| Rok vydania: | 2025 |
| Predmety: | attentional network function, Psychiatry, Neurophysiology and neuropsychology, QP351-495, fMRI, RC435-571, structure-function coupling, shift work disorder, Original Research |
| Popis: | INTRODUCTION: Previous studies on shift work disorder (SWD) have revealed altered functional and structural brain networks underlying attention decline. However, changes in structure-function coupling (SFC) and their relationship with attention decline remain unknown. This study aimed to examine the role of changed SFC in abnormal attentional network function in SWD. METHODS: Thirty-four patients with SWD and thirty-two healthy controls were recruited. All participants underwent resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) scans. All participants underwent an attentional network test to evaluate their functions. Finally, Pearson’s correlation analysis was conducted to analyze the association between aberrant attentional network function and altered structural and functional connectivity (SC-FC) coupling in patients with SWD. RESULTS: Compared to healthy subjects, decreased alerting and executive functions were found in patients with SWD. In addition, we observed decreased SC-FC coupling in patients with SWD, specifically in the left anterior cingulate gyrus (T = −3.6449, P = 0.0003), central opercular cortex (T = −3.7187, P = 0.0002), middle frontal gyrus (T = −3.8342, P = 0.0001), and parietal operculum cortex (T = −3.6121, P = 0.0003), compared with healthy subjects. Better altering performance was significantly associated with lower SC-FC coupling in the anterior cingulate gyrus of patients with SWD (r = −0.51, P = 0.002). DISCUSSION: Our findings unravel that the decreased SC-FC coupling in the anterior cingulate gyrus may contribute to the impaired altering network function in SWD, which can further understand the neural mechanisms of impaired attention in SWD and inform a potentially therapeutic intervention for SWD patients. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1179-1608 |
| DOI: | 10.2147/nss.s503303 |
| Prístupová URL adresa: | https://doaj.org/article/a3bb6e645e2a49aeb9478176b571e35b |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php). |
| Prístupové číslo: | edsair.doi.dedup.....04aa0bc7391838efc93f1bcf2e8dfb87 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | INTRODUCTION: Previous studies on shift work disorder (SWD) have revealed altered functional and structural brain networks underlying attention decline. However, changes in structure-function coupling (SFC) and their relationship with attention decline remain unknown. This study aimed to examine the role of changed SFC in abnormal attentional network function in SWD. METHODS: Thirty-four patients with SWD and thirty-two healthy controls were recruited. All participants underwent resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) scans. All participants underwent an attentional network test to evaluate their functions. Finally, Pearson’s correlation analysis was conducted to analyze the association between aberrant attentional network function and altered structural and functional connectivity (SC-FC) coupling in patients with SWD. RESULTS: Compared to healthy subjects, decreased alerting and executive functions were found in patients with SWD. In addition, we observed decreased SC-FC coupling in patients with SWD, specifically in the left anterior cingulate gyrus (T = −3.6449, P = 0.0003), central opercular cortex (T = −3.7187, P = 0.0002), middle frontal gyrus (T = −3.8342, P = 0.0001), and parietal operculum cortex (T = −3.6121, P = 0.0003), compared with healthy subjects. Better altering performance was significantly associated with lower SC-FC coupling in the anterior cingulate gyrus of patients with SWD (r = −0.51, P = 0.002). DISCUSSION: Our findings unravel that the decreased SC-FC coupling in the anterior cingulate gyrus may contribute to the impaired altering network function in SWD, which can further understand the neural mechanisms of impaired attention in SWD and inform a potentially therapeutic intervention for SWD patients. |
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| ISSN: | 11791608 |
| DOI: | 10.2147/nss.s503303 |