Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure
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| Title: | Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure |
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| Authors: | Kamburova, E.G., Wisse, B.W., Joosten, I., Allebes, W.A., van der Meer, A., Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., van Reekum, F.E., van Zuilen, A.D., Verhaar, M.C., Bots, M.L., Drop, A.C., Plaisier, L., Seelen, M.A., Sanders, J.S., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G., Voorter, C.E.M., Wieten, L., van Duijnhoven, E.M., Gelens, M.A., Christiaans, M.H., van Ittersum, F.J., Nurmohamed, S.A., Lardy, N.M., Swelsen, W., van der Pant, Karlijn A.M.I., van der Weerd, N.C., Ten Berge, I.J., Bemelman, F.J., Hoitsma, A.J., van der Boog, P.J., de Fijter, J.W., Betjes, M.G., Heidt, S., Roelen, D.L., Claas, F.H., Otten, H.G. |
| Contributors: | CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CDL Celdiagnostiek, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovascular Health |
| Source: | Kamburova, E G, Wisse, B W, Joosten, I, Allebes, W A, van der Meer, A, Hilbrands, L B, Baas, M C, Spierings, E, Hack, C E, van Reekum, F E, van Zuilen, A D, Verhaar, M C, Bots, M L, Drop, A C A D, Plaisier, L, Seelen, M A J, Sanders, J S, Hepkema, B G, Lambeck, A J A, Bungener, L B, Roozendaal, C, Tilanus, M G J, Voorter, C E, Wieten, L, van Duijnhoven, E M, Gelens, M A C J, Christiaans, M H L, van Ittersum, F J, Nurmohamed, S A, Lardy, N M, Swelsen, W, van der Pant, K A M I, van der Weerd, N C, Ten Berge, I J M, Bemelman, F J, Hoitsma, A J, van der Boog, P J M, de Fijter, J W, Betjes, M G H, Heidt, S, Roelen, D L, Claas, F H & Otten, H G 2018, 'Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure', Journal of the American Society of Nephrology, vol. 29, no. 9, pp. 2279-2285. https://doi.org/10.1681/ASN.2018020205 Journal of the American Society of Nephrology, 29, 9, pp. 2279-2285 |
| Publisher Information: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| Publication Year: | 2018 |
| Subject Terms: | Graft Rejection, Male, EMC MM-04-39-05, Preoperative Care/methods, Cohort Studies, 0302 clinical medicine, HLA Antigens, Taverne, Paediatrics - Radboud University Medical Center, Registries, Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences, chronic allograft failure, Kidney Transplantation/adverse effects, Incidence, Transplant Recipients/statistics & numerical data, Middle Aged, Tissue Donors, Antilymphocyte Serum/immunology, Antibodies, Anti-Idiotypic, 3. Good health, Anti-Idiotypic/immunology, Nephrology, Complement C3d, SURVIVAL, Female, HLA Antigens/immunology, Adult, Nephrology - Radboud University Medical Center, kidney transplantation, Risk Assessment, Antibodies, 03 medical and health sciences, Age Distribution, Transplantation Immunology, Complement C3d/immunology, Preoperative Care, Humans, Sex Distribution, Antilymphocyte Serum, Retrospective Studies, Radboudumc 11: Renal disorders RIHS: Radboud Institute for Health Sciences, TRANSPLANTATION, anti-HLA antibodies, Graft Rejection/epidemiology, Kidney Transplantation, RECIPIENTS, Laboratory Medicine - Radboud University Medical Center, complement-fixing antibodies, Radboudumc 0: Other Research RIMLS: Radboud Institute for Molecular Life Sciences, C1Q ASSAY, Follow-Up Studies |
| Description: | Background Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients. Methods Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay. Results Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non–C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non–C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non–C3d-fixing DSA; P=0.93). Patients without DSA had a 10-year graft survival of 78%. Conclusions The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1533-3450 1046-6673 |
| DOI: | 10.1681/asn.2018020205 |
| Access URL: | https://jasn.asnjournals.org/content/jnephrol/29/9/2279.full.pdf https://pubmed.ncbi.nlm.nih.gov/30049681 https://pure.eur.nl/en/publications/95bd6392-45a3-4daf-89cc-46eaaaf09f9e https://doi.org/10.1681/ASN.2018020205 https://research.rug.nl/en/publications/9d00dc65-77c6-4a73-9993-de89ffeee67c https://hdl.handle.net/11370/9d00dc65-77c6-4a73-9993-de89ffeee67c https://doi.org/10.1681/ASN.2018020205 https://cris.maastrichtuniversity.nl/en/publications/bcb56365-43f6-4b2e-a1e4-280ca39f46a6 https://doi.org/10.1681/ASN.2018020205 https://www.rug.nl/research/portal/publications/pretransplant-c3dfixing-donorspecific-antihla-antibodies-are-not-associated-with-increased-risk-for-kidney-graft-failure(9d00dc65-77c6-4a73-9993-de89ffeee67c).html https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F372960 https://europepmc.org/abstract/MED/30049681 https://researchinformation.amsterdamumc.org/en/publications/pretransplant-c3d-fixing-donor-specific-anti-hla-antibodies-are-n https://jasn.asnjournals.org/content/early/2018/07/25/ASN.2018020205 https://cris.maastrichtuniversity.nl/en/publications/pretransplant-c3d-fixing-donor-specific-anti-hla-antibodies-are-n https://research.vumc.nl/en/publications/f7a779ce-e1a0-4bcb-ae46-3b1963b64334 https://dspace.library.uu.nl/handle/1874/372960 https://hdl.handle.net/1887/88336 https://pure.amsterdamumc.nl/en/publications/22cfee18-8f09-4e4e-ad64-68cc9b67ba62 https://doi.org/10.1681/ASN.2018020205 https://hdl.handle.net/2066/196423 |
| Accession Number: | edsair.doi.dedup.....041fae52c5d70ab1a03991ebda5d2f21 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients. Methods Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay. Results Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non–C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non–C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non–C3d-fixing DSA; P=0.93). Patients without DSA had a 10-year graft survival of 78%. Conclusions The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure. |
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| ISSN: | 15333450 10466673 |
| DOI: | 10.1681/asn.2018020205 |