Zobrazit v EDS

The Role of Exerkines in the Treatment of Knee Osteoarthritis: From Mechanisms to Exercise Strategies

Uloženo v:
Podrobná bibliografie
Název: The Role of Exerkines in the Treatment of Knee Osteoarthritis: From Mechanisms to Exercise Strategies
Autoři: Yuxiong Xu, Yizhuo Yang, Hanan Song, Ming Li, Weihao Shi, Tongwu Yu, Jianhao Lin, Yanli Yu
Zdroj: Orthop Surg
Orthopaedic Surgery, Vol 17, Iss 4, Pp 1021-1035 (2025)
Informace o vydavateli: Wiley, 2025.
Rok vydání: 2025
Témata: Orthopedic surgery, exercise intensity, exercise modality, exerkines, Humans, Review Article, Osteoarthritis, Knee, knee osteoarthritis, RD701-811, Exercise Therapy
Popis: With the increasing prevalence of knee osteoarthritis (KOA), the limitations of traditional treatments, such as their limited efficacy in halting disease progression and their potential side effects, are becoming more evident. This situation has prompted scientists to seek more effective strategies. In recent years, exercise therapy has gained prominence in KOA treatment due to its safety, efficacy, and cost‐effectiveness, which are underpinned by the molecular actions of exerkines. Unlike conventional therapies, exerkines offer specific advantages by targeting inflammatory responses, enhancing chondrocyte proliferation, and slowing cartilage degradation at the molecular level. This review explores the potential mechanisms involved in and application prospects of exerkines in KOA treatment and provides a comprehensive analysis of their role. Studies show that appropriate exercise not only promotes overall health, but also positively impacts KOA by stimulating exerkine production. The effectiveness of exerkines, however, is influenced by exercise modality, intensity, and duration of exercise, making the development of personalized exercise plans crucial for KOA patients. Based on these insights, this paper proposes targeted exercise strategies designed to maximize exerkine benefits, aiming to provide novel perspectives for KOA prevention and treatment.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1757-7861
1757-7853
DOI: 10.1111/os.14365
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39854050
https://doaj.org/article/dbd4e5d969394466b7f9ae237544c0d1
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Přístupové číslo: edsair.doi.dedup.....03e7dba93c1523f822e73b54f95690ca
Databáze: OpenAIRE
Popis
Abstrakt:With the increasing prevalence of knee osteoarthritis (KOA), the limitations of traditional treatments, such as their limited efficacy in halting disease progression and their potential side effects, are becoming more evident. This situation has prompted scientists to seek more effective strategies. In recent years, exercise therapy has gained prominence in KOA treatment due to its safety, efficacy, and cost‐effectiveness, which are underpinned by the molecular actions of exerkines. Unlike conventional therapies, exerkines offer specific advantages by targeting inflammatory responses, enhancing chondrocyte proliferation, and slowing cartilage degradation at the molecular level. This review explores the potential mechanisms involved in and application prospects of exerkines in KOA treatment and provides a comprehensive analysis of their role. Studies show that appropriate exercise not only promotes overall health, but also positively impacts KOA by stimulating exerkine production. The effectiveness of exerkines, however, is influenced by exercise modality, intensity, and duration of exercise, making the development of personalized exercise plans crucial for KOA patients. Based on these insights, this paper proposes targeted exercise strategies designed to maximize exerkine benefits, aiming to provide novel perspectives for KOA prevention and treatment.
ISSN:17577861
17577853
DOI:10.1111/os.14365