View in EDS

Effects of amygdala–hippocampal stimulation on interictal epileptic discharges

Saved in:
Bibliographic Details
Title: Effects of amygdala–hippocampal stimulation on interictal epileptic discharges
Authors: Tyrand, Rémi, Seeck, Margitta, Spinelli, Laurent Jean-François, Pralong, Emmanuel, Vulliemoz, Serge, Foletti, G, Rossetti, A O, Allali, Gilles, Lantz, Goran, Pollo, Claudio, Boex, Colette
Source: Epilepsy Research, Vol. 99, No 1-2 (2012) pp. 87-93
Epilepsy Research
Publisher Information: Elsevier BV, 2012.
Publication Year: 2012
Subject Terms: Adult, Male, 616.8, Epilepsy, Deep Brain Stimulation, Middle Aged, Amygdala, Hippocampus, ddc:616.8, Young Adult, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Deep Brain Stimulation/methods, Amygdala/physiology, Humans, Female, Hippocampus/physiology, Epilepsy/physiopathology/therapy
Description: Deep brain stimulation (DBS) of different nuclei is being evaluated as a treatment for epilepsy. While encouraging results have been reported, the effects of changes in stimulation parameters have been poorly studied. Here the effects of changes of pulse waveform in high frequency DBS (130 Hz) of the amygdala-hippocampal complex (AH) are presented. These effects were studied on interictal epileptic discharge rates (IEDRs). AH-DBS was implemented with biphasic versus pseudo monophasic charge balanced pulses, in two groups of patients: six with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) and six with non lesional (NLES) temporal epilepsy. In patients with HS, IEDRs were significantly reduced with AH-DBS applied with biphasic pulses in comparison with monophasic pulse. IEDRs were significantly reduced in only two patients with NLES independently to stimulus waveform. Comparison to long-term seizure outcome suggests that IEDRs could be used as a neurophysiological marker of chronic AH-DBS and they suggest that the waveform of the electrical stimuli can play a major role in DBS. We concluded that biphasic stimuli are more efficient than pseudo monophasic pulses in AH-DBS in patients with HS. In patients with NLES epilepsy, other parameters relevant for efficacy of DBS remain to be determined.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 0920-1211
DOI: 10.1016/j.eplepsyres.2011.10.026
Access URL: https://pubmed.ncbi.nlm.nih.gov/22079883
http://www.ncbi.nlm.nih.gov/pubmed/22079883
https://archive-ouverte.unige.ch/unige:32815
https://www.sciencedirect.com/science/article/pii/S0920121111003342
https://boris.unibe.ch/14841/
http://core.ac.uk/display/18150228
https://archive-ouverte.unige.ch/unige:32815
Rights: Elsevier TDM
Accession Number: edsair.doi.dedup.....03e4d802659d49e7b9bb6a9d5c6aaa8a
Database: OpenAIRE
Description
Abstract:Deep brain stimulation (DBS) of different nuclei is being evaluated as a treatment for epilepsy. While encouraging results have been reported, the effects of changes in stimulation parameters have been poorly studied. Here the effects of changes of pulse waveform in high frequency DBS (130 Hz) of the amygdala-hippocampal complex (AH) are presented. These effects were studied on interictal epileptic discharge rates (IEDRs). AH-DBS was implemented with biphasic versus pseudo monophasic charge balanced pulses, in two groups of patients: six with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) and six with non lesional (NLES) temporal epilepsy. In patients with HS, IEDRs were significantly reduced with AH-DBS applied with biphasic pulses in comparison with monophasic pulse. IEDRs were significantly reduced in only two patients with NLES independently to stimulus waveform. Comparison to long-term seizure outcome suggests that IEDRs could be used as a neurophysiological marker of chronic AH-DBS and they suggest that the waveform of the electrical stimuli can play a major role in DBS. We concluded that biphasic stimuli are more efficient than pseudo monophasic pulses in AH-DBS in patients with HS. In patients with NLES epilepsy, other parameters relevant for efficacy of DBS remain to be determined.
ISSN:09201211
DOI:10.1016/j.eplepsyres.2011.10.026