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High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy

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Názov: High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy
Autori: Jong-Hwa Won, Ying-Ying Xiang, Kyung-Wan Baek, Min-Jeong Kang, Ji-Seok Kim
Zdroj: International Neurourology Journal, Vol 29, Iss Suppl 1, Pp S44-S52 (2025)
Informácie o vydavateľovi: Korean Continence Society, 2025.
Rok vydania: 2025
Predmety: muscle atrophy, autophagy, aerobic exercise, RC870-923, angiotensin ii, Diseases of the genitourinary system. Urology
Popis: Purpose: Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrophy remain unclear. Moreover, the potential protective effects of aerobic exercise against Ang II-induced muscle alterations have not been fully elucidated. This study aimed to investigate the effects of Ang II on skeletal muscle structure and atrophy-related molecular markers and to assess whether aerobic exercise can confer protective effects against these changes in an Ang II-induced animal model.Methods: Six-week-old mice (n =48) were divided into 4 groups: (1) control (CON, n =12), (2) Ang II (n =12), (3) Ang II plus low-intensity exercise (Ang II+LIE, n=12), and (4) Ang II plus high-intensity exercise (Ang II+HIE, n=12). Ang II was administered subcutaneously once daily for 4 weeks (1.4 mg/kg/day in phosphate-buffered saline, pH 7.2). The Ang II+LIE and Ang II+HIE groups received daily Ang II injections along with their respective exercise protocols for 4 weeks.Results: The protein expression of inflammatory factors was significantly reduced in the Ang II+HIE group compared to the Ang II group (P < 0.05). Furthermore, the expression of muscle protein synthesis markers, including insulin-like growth factor 1, AKT, mammalian target of rapamycin, and S6K1, was significantly higher in the exercise groups than in the Ang II group (P
Druh dokumentu: Article
Jazyk: English
ISSN: 2093-6931
DOI: 10.5213/inj.2550150.075
Prístupová URL adresa: https://doaj.org/article/7b4c2ad996d040d1b86612f589e2f89c
Rights: CC BY NC
Prístupové číslo: edsair.doi.dedup.....039d520da3f6193c4a287538e204bb66
Databáza: OpenAIRE
Popis
Abstrakt:Purpose: Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrophy remain unclear. Moreover, the potential protective effects of aerobic exercise against Ang II-induced muscle alterations have not been fully elucidated. This study aimed to investigate the effects of Ang II on skeletal muscle structure and atrophy-related molecular markers and to assess whether aerobic exercise can confer protective effects against these changes in an Ang II-induced animal model.Methods: Six-week-old mice (n =48) were divided into 4 groups: (1) control (CON, n =12), (2) Ang II (n =12), (3) Ang II plus low-intensity exercise (Ang II+LIE, n=12), and (4) Ang II plus high-intensity exercise (Ang II+HIE, n=12). Ang II was administered subcutaneously once daily for 4 weeks (1.4 mg/kg/day in phosphate-buffered saline, pH 7.2). The Ang II+LIE and Ang II+HIE groups received daily Ang II injections along with their respective exercise protocols for 4 weeks.Results: The protein expression of inflammatory factors was significantly reduced in the Ang II+HIE group compared to the Ang II group (P < 0.05). Furthermore, the expression of muscle protein synthesis markers, including insulin-like growth factor 1, AKT, mammalian target of rapamycin, and S6K1, was significantly higher in the exercise groups than in the Ang II group (P
ISSN:20936931
DOI:10.5213/inj.2550150.075