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The age of the obesity onset is a very important factor for the development of metabolic complications and cardiovascular risk in children and adolescents with severe obesity

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Název: The age of the obesity onset is a very important factor for the development of metabolic complications and cardiovascular risk in children and adolescents with severe obesity
Autoři: Ewa Szczudlik, Anna Stępniewska, Mirosław Bik-Multanowski, Stephanie Brandt-Heunemann, Bertram Flehmig, Ewa Małecka-Tendera, Artur Mazur, Elżbieta Petriczko, Michael B. Ranke, Martin Wabitsch, Agnieszka Zachurzok, Małgorzata Wójcik
Zdroj: Eur J Pediatr
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, Metabolic Syndrome, 2. Zero hunger, Pediatric Obesity, Adolescent, High blood pressure, Adolescent [MeSH], Female [MeSH], Adolescents, Metabolic Syndrome/epidemiology [MeSH], Pediatric Obesity/epidemiology [MeSH], Humans [MeSH], Cardiovascular Diseases/etiology [MeSH], Pediatric Obesity/complications [MeSH], Cardiovascular Diseases/epidemiology [MeSH], Poland/epidemiology [MeSH], Risk Factors [MeSH], Obesity, Morbid/complications [MeSH], Body Mass Index [MeSH], Metabolic complications, Heart Disease Risk Factors [MeSH], Age of Onset [MeSH], Male [MeSH], Children, Metabolic Syndrome/diagnosis [MeSH], Research, Severe obesity, Child [MeSH], Metabolic Syndrome/complications [MeSH], Obesity, Morbid, Body Mass Index, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Cardiovascular Diseases, Heart Disease Risk Factors, Risk Factors, Humans, Female, Poland, Age of Onset, Child
Popis: Severe obesity defined as BMI value corresponding to an adult > 40 kg/m2 affects 1–5% of children and adolescents in Europe. The purpose of this study was to assess the occurrence of cardiovascular risk factors in children and adolescents with severe obesity. The analysis included 140 patients (75 female) at the mean age of 14 ± 2.1 SD (range 10–18) years (all recruited in 4 regional reference centers in Poland). Severe obesity was defined as BMI > 35 kg/m2 (children 6–14 years), and BMI > 40 kg/m2 (> 14 years). Fasting plasma samples have been obtained in all patients, and OGTT was performed in all patients. The metabolic risk factors were defined as high blood pressure (BP > 90 percentile for height, age, and sex), HDL cholesterol 5.6 mmol/L, or blood glucose 120′ after oral glucose load > 7.8 mmol/L). Additionally, the MetS z-score was calculated using Metabolic Syndrome Severity Calculator. One hundred twenty-four (89%) participants presented with high BP, 117 (84%) with abnormal lipid profile, and 26 with the hyperglycemic. Only 12 (9%) were free of metabolic complications. More than 60% of patients had more than one cardiovascular risk factor. The high BP was significantly associated with the severity of obesity (F = 9.9, p = 0.002). Patients with at least one metabolic complication presented with significantly younger age of the onset of obesity (the mean age of the patients with no overt obesity complications was 10 years, while the mean age of those who presented at least one was 4.7 ± 3.5 SD years (p = 0.002)). A significant positive association between in the value of the Mets BMI z-score with age was observed (R = 0.2, p Mets BMI z-score (1.7 ± 0.8 vs 1.7 ± 0.7, p = 0.8).Conclusions: The most common metabolic risk factor in children and adolescents with severe obesity was high BP. The most important factor determining presence of obesity complications, and thus the total metabolic risk, seems to be younger ( What is Known?• It is estimated that 1-5% of children and adolescents in Europe suffer from severe obesity corresponding to an adult BMI > 40 kg/m2, and it is the fastest growing subcategory of childhood obesity.• Children with severe obesity face substantial health risk that may persist into adulthood, encompassing chronic conditions, psychological disorders and premature mortality. What is new:• The most common complication is high BP that is significantly associated with the severity of obesity (BMI z-score), contrary to dyslipidemia and hyperglycemic state, which do not depend on BMI z-score value.• The most important factor determining presence of obesity complications, and thus the total metabolic risk, seems to be younger (
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-1076
DOI: 10.1007/s00431-024-05636-x
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38877324
https://link.springer.com/article/10.1007/s00431-024-05636-x
https://doi.org/10.1007/s00431-024-05636-x
https://ruj.uj.edu.pl/handle/item/419245
https://link.springer.com/article/10.1007/s00431-024-05636-x
https://repository.publisso.de/resource/frl:6519429
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....02df07f8db4a2c6eee0bc5569e0d87e7
Databáze: OpenAIRE
Popis
Abstrakt:Severe obesity defined as BMI value corresponding to an adult > 40 kg/m2 affects 1–5% of children and adolescents in Europe. The purpose of this study was to assess the occurrence of cardiovascular risk factors in children and adolescents with severe obesity. The analysis included 140 patients (75 female) at the mean age of 14 ± 2.1 SD (range 10–18) years (all recruited in 4 regional reference centers in Poland). Severe obesity was defined as BMI > 35 kg/m2 (children 6–14 years), and BMI > 40 kg/m2 (> 14 years). Fasting plasma samples have been obtained in all patients, and OGTT was performed in all patients. The metabolic risk factors were defined as high blood pressure (BP > 90 percentile for height, age, and sex), HDL cholesterol 5.6 mmol/L, or blood glucose 120′ after oral glucose load > 7.8 mmol/L). Additionally, the MetS z-score was calculated using Metabolic Syndrome Severity Calculator. One hundred twenty-four (89%) participants presented with high BP, 117 (84%) with abnormal lipid profile, and 26 with the hyperglycemic. Only 12 (9%) were free of metabolic complications. More than 60% of patients had more than one cardiovascular risk factor. The high BP was significantly associated with the severity of obesity (F = 9.9, p = 0.002). Patients with at least one metabolic complication presented with significantly younger age of the onset of obesity (the mean age of the patients with no overt obesity complications was 10 years, while the mean age of those who presented at least one was 4.7 ± 3.5 SD years (p = 0.002)). A significant positive association between in the value of the Mets BMI z-score with age was observed (R = 0.2, p Mets BMI z-score (1.7 ± 0.8 vs 1.7 ± 0.7, p = 0.8).Conclusions: The most common metabolic risk factor in children and adolescents with severe obesity was high BP. The most important factor determining presence of obesity complications, and thus the total metabolic risk, seems to be younger ( What is Known?• It is estimated that 1-5% of children and adolescents in Europe suffer from severe obesity corresponding to an adult BMI > 40 kg/m2, and it is the fastest growing subcategory of childhood obesity.• Children with severe obesity face substantial health risk that may persist into adulthood, encompassing chronic conditions, psychological disorders and premature mortality. What is new:• The most common complication is high BP that is significantly associated with the severity of obesity (BMI z-score), contrary to dyslipidemia and hyperglycemic state, which do not depend on BMI z-score value.• The most important factor determining presence of obesity complications, and thus the total metabolic risk, seems to be younger (
ISSN:14321076
DOI:10.1007/s00431-024-05636-x