Biochemical osteomalacia in adults undergoing vitamin D testing in the North-East of Scotland
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| Název: | Biochemical osteomalacia in adults undergoing vitamin D testing in the North-East of Scotland |
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| Autoři: | Angus D Macleod, Mark J Bolland, Andrew Balfour, Andrew Grey, Josh Newmark, Alison Avenell |
| Přispěvatelé: | University of Aberdeen.Aberdeen Centre for Health Data Science, University of Aberdeen.Grampian Data Safe Haven (DaSH), University of Aberdeen.Chronic Disease Research Group, University of Aberdeen.Other Applied Health Sciences, University of Aberdeen.Aberdeen Centre for Evaluation, University of Aberdeen.Institute of Applied Health Sciences |
| Zdroj: | Ann Clin Biochem |
| Informace o vydavateli: | SAGE Publications, 2025. |
| Rok vydání: | 2025 |
| Témata: | insufficiency, Supplementary Data, hypocalcaemia, Clinical Biochemistry, deficiency, osteomalacia, Vitamin D, R Medicine, Research Articles |
| Popis: | Background International guidelines give greatly varying definitions of 25-hydroxyvitamin D (25OHD) insufficiency and deficiency. Vitamin D testing is increasing despite 2016 UK guidance for adults advising routine vitamin D supplementation October-March and year-round for high risk groups. A service evaluation of vitamin D testing and biochemical osteomalacia in the North-East of Scotland (57–58°N) could inform definitions and testing guidance. Methods We identified adult 25OHD requests 8/7/2008–29/2/2020 and albumin-adjusted serum calcium (aCa), parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of 25OHD testing. After excluding renal impairment and liver disease, we defined biochemical osteomalacia as ALP >130 IU/L and aCa 9.2 or >6.8 pmol/L, depending on the assay. Possible biochemical osteomalacia was defined as 2 of these abnormalities in the absence of the third measurement. From these cases anonymised clinical data were then examined to confirm the diagnosis of osteomalacia. Results 25,379 eligible patients had 25OHD measured: 25% were 25 nmol/L. For the entire tested population, when 25OHD was Conclusions Osteomalacia is rare in North-East Scotland. Our data call into question designating 25OHD 25–50 nmol/L ‘insufficiency’. The risk of osteomalacia even when 25OHD is |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/00045632251315671 |
| Rights: | URL: https://journals.sagepub.com/page/policies/text-and-data-mining-license URL: http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the Sage and Open Access page (http://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Přístupové číslo: | edsair.doi.dedup.....02d38c9ca93d4efa5f744b36a38c7cda |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background International guidelines give greatly varying definitions of 25-hydroxyvitamin D (25OHD) insufficiency and deficiency. Vitamin D testing is increasing despite 2016 UK guidance for adults advising routine vitamin D supplementation October-March and year-round for high risk groups. A service evaluation of vitamin D testing and biochemical osteomalacia in the North-East of Scotland (57–58°N) could inform definitions and testing guidance. Methods We identified adult 25OHD requests 8/7/2008–29/2/2020 and albumin-adjusted serum calcium (aCa), parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of 25OHD testing. After excluding renal impairment and liver disease, we defined biochemical osteomalacia as ALP >130 IU/L and aCa 9.2 or >6.8 pmol/L, depending on the assay. Possible biochemical osteomalacia was defined as 2 of these abnormalities in the absence of the third measurement. From these cases anonymised clinical data were then examined to confirm the diagnosis of osteomalacia. Results 25,379 eligible patients had 25OHD measured: 25% were 25 nmol/L. For the entire tested population, when 25OHD was Conclusions Osteomalacia is rare in North-East Scotland. Our data call into question designating 25OHD 25–50 nmol/L ‘insufficiency’. The risk of osteomalacia even when 25OHD is |
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| ISSN: | 17581001 00045632 |
| DOI: | 10.1177/00045632251315671 |