ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans
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| Titel: | ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans |
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| Autoren: | Hingley-Wilson, SM, Connell, D, Pollock, K, Grass, L, Potiphar, L, Bremang, S, Lalvani, A, Hsu, T, Jacobs Jr, WR, Tchilian, E, Sykes, A, Kon, OM |
| Weitere Verfasser: | Medical Research Council (MRC) |
| Quelle: | Tuberculosis (Edinb) |
| Verlagsinformationen: | Elsevier BV, 2014. |
| Publikationsjahr: | 2014 |
| Schlagwörter: | 0301 basic medicine, ESX-1, Respiratory System, Monocytes, Macrophages/microbiology, Mice, MACROPHAGES, Inbred BALB C, Cells, Cultured, Mice, Inbred BALB C, 0303 health sciences, Cultured, INDUCTION, Chemotaxis, ESAT-6/CFP-10, 11 Medical And Health Sciences, Mechanisms of Pathogenesis, 3. Good health, Infectious Diseases, SURVIVAL, Bacterial Proteins/physiology, Infection, Life Sciences & Biomedicine, EXPRESSION, Microbiology (medical), Cells, Immunology, Chemotaxis/physiology, Microbiology, Antigens, CD11, Fractalkine, CX3CL1, Mycobacterium, 03 medical and health sciences, Bacterial Proteins, Mycobacterium tuberculosis/pathogenicity, CD11 Antigens/metabolism, Animals, Humans, Tuberculosis, Tuberculosis/microbiology, Science & Technology, Monocytes/microbiology, GRANULOMA-FORMATION, CD11 Antigens, Chemokine CX3CL1, Macrophages, Mycobacterium tuberculosis, CHEMOKINE, Matrix Metalloproteinases, Chemokine CX3CL1/metabolism, Matrix Metalloproteinases/metabolism, CALMETTE-GUERIN, VIRULENCE, RC |
| Beschreibung: | Mycobacterium tuberculosis-induced cellular aggregation is essential for granuloma formation and may assist establishment and early spread of M. tuberculosis infection. The M. tuberculosis ESX1 mutant, which has a non-functional type VII secretion system, induced significantly less production of the host macrophage-derived chemokine fractalkine (CX3CL1). Upon infection of human macrophages ESX1-dependent fractalkine production mediated selective recruitment of CD11b+ monocytic cells and increased infection of neighbouring cells consistent with early local spread of infection. Fractalkine levels were raised in vivo at tuberculous disease sites in humans and were significantly associated with increased CD11b+ monocytic cellular recruitment and extent of granulomatous disease. These findings suggest a novel fractalkine-dependent ESX1-mediated mechanism in early tuberculous disease pathogenesis in humans. Modulation of M. tuberculosis-mediated fractalkine induction may represent a potential treatment option in the future, perhaps allowing us to switch off a key mechanism required by the pathogen to spread between cells. |
| Publikationsart: | Article Conference object Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1472-9792 |
| DOI: | 10.1016/j.tube.2014.01.004 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/24631198 https://core.ac.uk/display/82548415 http://epubs.surrey.ac.uk/826657/ https://www.sciencedirect.com/science/article/pii/S1472979214000055 https://www.sciencedirect.com/science/article/abs/pii/S1472979214000055 http://eprints.glos.ac.uk/8149/ http://hdl.handle.net/10044/1/62137 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) . |
| Dokumentencode: | edsair.doi.dedup.....02c18d36eda9805b959d1f90fe0e6728 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Mycobacterium tuberculosis-induced cellular aggregation is essential for granuloma formation and may assist establishment and early spread of M. tuberculosis infection. The M. tuberculosis ESX1 mutant, which has a non-functional type VII secretion system, induced significantly less production of the host macrophage-derived chemokine fractalkine (CX3CL1). Upon infection of human macrophages ESX1-dependent fractalkine production mediated selective recruitment of CD11b+ monocytic cells and increased infection of neighbouring cells consistent with early local spread of infection. Fractalkine levels were raised in vivo at tuberculous disease sites in humans and were significantly associated with increased CD11b+ monocytic cellular recruitment and extent of granulomatous disease. These findings suggest a novel fractalkine-dependent ESX1-mediated mechanism in early tuberculous disease pathogenesis in humans. Modulation of M. tuberculosis-mediated fractalkine induction may represent a potential treatment option in the future, perhaps allowing us to switch off a key mechanism required by the pathogen to spread between cells. |
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| ISSN: | 14729792 |
| DOI: | 10.1016/j.tube.2014.01.004 |