Two common mild analgesics have no effect on general endocrine mediated endpoints in zebrafish (Danio rerio)
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| Title: | Two common mild analgesics have no effect on general endocrine mediated endpoints in zebrafish (Danio rerio) |
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| Authors: | Morthorst, Jane Ebsen, Lund, Birgit, Holbech, Henrik, Bjerregaard, Poul |
| Source: | Morthorst, J E, Lund, B, Holbech, H & Bjerregaard, P 2018, ' Two common mild analgesics have no effect on general endocrine mediated endpoints in zebrafish (Danio rerio) ', Comparative Biochemistry and Physiology-Part C: Toxicology & Pharmacology, vol. 204, pp. 63-70 . https://doi.org/10.1016/j.cbpc.2017.11.009 |
| Publisher Information: | Elsevier BV, 2018. |
| Publication Year: | 2018 |
| Subject Terms: | 0301 basic medicine, Anti-Inflammatory Agents, Non-Steroidal/administration & dosage, Anti-Inflammatory Agents, Developmental/drug effects, Endocrine Disruptors, Ovum/drug effects, Dose-Response Relationship, Larva/drug effects, Vitellogenins, 03 medical and health sciences, Acetaminophen/administration & dosage, Animals, Sex Ratio, Analgesics, Non-Narcotic/administration & dosage, Aspirin/administration & dosage, Non-Steroidal/administration & dosage, Zebrafish, Acetaminophen, Ovum, Analgesics, 0303 health sciences, Gene Expression Regulation, Developmental/drug effects, Aspirin, Dose-Response Relationship, Drug, Vitellogenins/genetics, Anti-Inflammatory Agents, Non-Steroidal, Gene Expression Regulation, Developmental, Analgesics, Non-Narcotic, Gene Expression Regulation, Larva, Prostaglandins, Non-Narcotic/administration & dosage, Drug, Prostaglandins/metabolism |
| Description: | Mild analgesics such as acetylsalicylic acid (ASA) and acetaminophen (APAP) exert their pain-relieving effect in humans by inhibition of prostaglandin synthesis. Prostaglandins play key roles in developmental and reproductive processes in vertebrates, and in recent years, it has been suggested that weak analgesics might also act as endocrine disrupters. In a set of experiments we investigated if ASA and APAP affect well-established endocrine endpoints in zebrafish (Danio rerio), which is a commonly used model organism in the investigation of endocrine disrupting chemicals. Zebrafish were exposed to APAP (0.22, 2.3, and 30mgL-1) or ASA (0.2, 0.5, 1.7, and 8.2mgL-1) from hatch to sexual maturity in a test design resembling the OECD Fish Sexual Development Test. No effects on sex ratio and vitellogenin levels were observed. Adult zebrafish were exposed to high concentrations (mgL-1) of ASA or APAP for eight or 14days. ASA reduced the levels of prostaglandin E2, but had no effect on the concentration of 11-ketotestosterone and vitellogenin. Overall, ASA decrease prostaglandin E2 concentrations, but well-established endpoints for endocrine disruption in zebrafish are generally not affected by aquatic exposure neither during development nor adulthood. According to the WHO/IPCS definition of an endocrine disrupter, the present results do not define APAP and ASA as endocrine disrupters. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1532-0456 |
| DOI: | 10.1016/j.cbpc.2017.11.009 |
| Access URL: | https://findresearcher.sdu.dk:8443/ws/files/134559584/Two_common_mild_analgesics_have_no_effect_on_general_endocrine_mediated_endpoints_in_zebrafish_Danio_rerio_.pdf https://pubmed.ncbi.nlm.nih.gov/29180113 https://www.sciencedirect.com/science/article/abs/pii/S1532045617302144#! https://findresearcher.sdu.dk:8443/ws/files/134559584/Two_common_mild_analgesics_have_no_effect_on_general_endocrine_mediated_endpoints_in_zebrafish_Danio_rerio_.pdf http://findresearcher.sdu.dk/portal/en/publications/two-common-mild-analgesics-have-no-effect-on-general-endocrine-mediated-endpoints-in-zebrafish-danio-rerio(9fd77419-36db-4d40-9cac-e1f534323ebf).html https://www.ncbi.nlm.nih.gov/pubmed/29180113 https://portal.findresearcher.sdu.dk/en/publications/two-common-mild-analgesics-have-no-effect-on-general-endocrine-me https://www.sciencedirect.com/science/article/pii/S1532045617302144 https://portal.findresearcher.sdu.dk/da/publications/9fd77419-36db-4d40-9cac-e1f534323ebf https://doi.org/10.1016/j.cbpc.2017.11.009 |
| Rights: | Elsevier TDM CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....023b163db2b4f8c74c1ceb7e840cf099 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Mild analgesics such as acetylsalicylic acid (ASA) and acetaminophen (APAP) exert their pain-relieving effect in humans by inhibition of prostaglandin synthesis. Prostaglandins play key roles in developmental and reproductive processes in vertebrates, and in recent years, it has been suggested that weak analgesics might also act as endocrine disrupters. In a set of experiments we investigated if ASA and APAP affect well-established endocrine endpoints in zebrafish (Danio rerio), which is a commonly used model organism in the investigation of endocrine disrupting chemicals. Zebrafish were exposed to APAP (0.22, 2.3, and 30mgL-1) or ASA (0.2, 0.5, 1.7, and 8.2mgL-1) from hatch to sexual maturity in a test design resembling the OECD Fish Sexual Development Test. No effects on sex ratio and vitellogenin levels were observed. Adult zebrafish were exposed to high concentrations (mgL-1) of ASA or APAP for eight or 14days. ASA reduced the levels of prostaglandin E2, but had no effect on the concentration of 11-ketotestosterone and vitellogenin. Overall, ASA decrease prostaglandin E2 concentrations, but well-established endpoints for endocrine disruption in zebrafish are generally not affected by aquatic exposure neither during development nor adulthood. According to the WHO/IPCS definition of an endocrine disrupter, the present results do not define APAP and ASA as endocrine disrupters. |
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| ISSN: | 15320456 |
| DOI: | 10.1016/j.cbpc.2017.11.009 |