Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders
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| Názov: | Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders |
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| Autori: | Meera Chikermane, Sven Jarius, Hanna Zimmermann, Friedemann Paul, Frederike C. Oertel, Graham Cooper, Claudia Chien, Susanna Asseyer, Klemens Ruprecht, Valentin Juenger, Joseph Kuchling, Michael Scheel, Nadja Siebert, Judith Bellmann-Strobl, Alexander U. Brandt, Athina Papadopoulou |
| Zdroj: | Eur Radiol |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2020. |
| Rok vydania: | 2020 |
| Predmety: | Adult, Male, Retinal Ganglion Cells, Optic Neuritis, Visual Acuity, Optic neuritis, Retina, 03 medical and health sciences, Imaging, Three-Dimensional, Magnetic resonance imaging, 0302 clinical medicine, Humans, Visual Pathways, 10. No inequality, Aged [MeSH], Optic Chiasm/diagnostic imaging [MeSH], Neuromyelitis Optica/physiopathology [MeSH], Visual Pathways/diagnostic imaging [MeSH], Optic Chiasm/pathology [MeSH], Magnetic Resonance Imaging [MeSH], Visual Acuity [MeSH], Optic Neuritis [MeSH], Organ Size [MeSH], Male [MeSH], Case-Control Studies [MeSH], Optic chiasm, Neuromyelitis Optica/diagnostic imaging [MeSH], Retina/diagnostic imaging [MeSH], Retina/pathology [MeSH], Retinal Ganglion Cells/pathology [MeSH], Visual Pathways/pathology [MeSH], Female [MeSH], Adult [MeSH], Humans [MeSH], Neuromyelitis optica, Middle Aged [MeSH], Cross-Sectional Studies [MeSH], Aquaporin 4 [MeSH], Imaging, Three-Dimensional [MeSH], Neuro, Optic Nerve/diagnostic imaging [MeSH], Aged, Aquaporin 4, Neuromyelitis Optica, Optic Nerve, Organ Size, Middle Aged, Magnetic Resonance Imaging, Cross-Sectional Studies, Case-Control Studies, Optic Chiasm, Female, Function and Dysfunction of the Nervous System, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| Popis: | Objectives We aimed to evaluate optic chiasm (OC) measures as potential imaging marker for anterior optic pathway damage assessment in the context of neuromyelitis optica spectrum disorders (NMOSD). Materials and method This cross-sectional study included 39 patients exclusively with aquaporin 4-IgG seropositive NMOSD of which 25 patients had a history of optic neuritis (NMOSD-ON) and 37 age- and sex-matched healthy controls (HC). OC heights, width, and area were measured using standard 3D T1-weighted MRI. Sensitivity of these measures to detect neurodegeneration in the anterior optic pathway was assessed in receiver operating characteristics analyses. Correlation coefficients were used to assess associations with structural measures of the anterior optic pathway (optic nerve dimensions, retinal ganglion cell loss) and clinical measures (visual function and disease duration). Results OC heights and area were significantly smaller in NMOSD-ON compared to HC (NMOSD-ON vs. HC p smaller than 22.5 mm2 yielded a sensitivity of 0.92 and a specificity of 0.92 in separating chiasms of NMOSD-ON from HC. OC area correlated well with structural and clinical measures in NMOSD-ON: optic nerve diameter (r = 0.4, p = 0.047), peripapillary retinal nerve fiber layer thickness (r = 0.59, p = 0.003), global visual acuity (r = − 0.57, p = 0.013), and diseases duration (r = − 0.5, p = 0.012). Conclusion Our results suggest that OC measures are promising and easily accessible imaging markers for the assessment of anterior optic pathway damage. Key Points • Optic chiasm dimensions were smaller in neuromyelitis optica spectrum disorder patients compared to healthy controls. • Optic chiasm dimensions are associated with retinal measures and visual dysfunction. • The optic chiasm might be used as an easily accessible imaging marker of neurodegeneration in the anterior optic pathway with potential functional relevance. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-020-06859-w |
| DOI: | 10.17169/refubium-35777 |
| Prístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s00330-020-06859-w.pdf https://pubmed.ncbi.nlm.nih.gov/32335748 https://www.ncbi.nlm.nih.gov/pubmed/32335748 https://pubmed.ncbi.nlm.nih.gov/32335748/ https://paperity.org/p/248212169/optic-chiasm-measurements-may-be-useful-markers-of-anterior-optic-pathway-degeneration-in https://inis.iaea.org/search/search.aspx?orig_q=RN:51111996 https://link.springer.com/content/pdf/10.1007%2Fs00330-020-06859-w.pdf https://link.springer.com/article/10.1007/s00330-020-06859-w http://edoc.mdc-berlin.de/18887/1/18887oa.pdf https://repository.publisso.de/resource/frl:6469234 https://refubium.fu-berlin.de/handle/fub188/36061 https://doi.org/10.1007/s00330-020-06859-w https://doi.org/10.17169/refubium-35777 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....0222de7d227c199cea571b96df29ec22 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Objectives We aimed to evaluate optic chiasm (OC) measures as potential imaging marker for anterior optic pathway damage assessment in the context of neuromyelitis optica spectrum disorders (NMOSD). Materials and method This cross-sectional study included 39 patients exclusively with aquaporin 4-IgG seropositive NMOSD of which 25 patients had a history of optic neuritis (NMOSD-ON) and 37 age- and sex-matched healthy controls (HC). OC heights, width, and area were measured using standard 3D T1-weighted MRI. Sensitivity of these measures to detect neurodegeneration in the anterior optic pathway was assessed in receiver operating characteristics analyses. Correlation coefficients were used to assess associations with structural measures of the anterior optic pathway (optic nerve dimensions, retinal ganglion cell loss) and clinical measures (visual function and disease duration). Results OC heights and area were significantly smaller in NMOSD-ON compared to HC (NMOSD-ON vs. HC p smaller than 22.5 mm2 yielded a sensitivity of 0.92 and a specificity of 0.92 in separating chiasms of NMOSD-ON from HC. OC area correlated well with structural and clinical measures in NMOSD-ON: optic nerve diameter (r = 0.4, p = 0.047), peripapillary retinal nerve fiber layer thickness (r = 0.59, p = 0.003), global visual acuity (r = − 0.57, p = 0.013), and diseases duration (r = − 0.5, p = 0.012). Conclusion Our results suggest that OC measures are promising and easily accessible imaging markers for the assessment of anterior optic pathway damage. Key Points • Optic chiasm dimensions were smaller in neuromyelitis optica spectrum disorder patients compared to healthy controls. • Optic chiasm dimensions are associated with retinal measures and visual dysfunction. • The optic chiasm might be used as an easily accessible imaging marker of neurodegeneration in the anterior optic pathway with potential functional relevance. |
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| ISSN: | 14321084 09387994 |
| DOI: | 10.1007/s00330-020-06859-w |