Association of Motoric Cognitive Risk Syndrome and High C-Reactive Protein Serum Levels With Incident Major Neurocognitive Disorder: Results From the Quebec NuAge Cohort
Uložené v:
| Názov: | Association of Motoric Cognitive Risk Syndrome and High C-Reactive Protein Serum Levels With Incident Major Neurocognitive Disorder: Results From the Quebec NuAge Cohort |
|---|---|
| Autori: | Olivier Beauchet, Kevin Galéry, Pierrette Gaudreau, Gilles Allali |
| Zdroj: | J Gerontol A Biol Sci Med Sci The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 80, no. 3 |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2025. |
| Rok vydania: | 2025 |
| Predmety: | Male, Aged, 80 and over, Humans, Female, C-Reactive Protein/analysis, C-Reactive Protein/metabolism, Aged, Quebec/epidemiology, Incidence, Risk Factors, Neurocognitive Disorders/epidemiology, Neurocognitive Disorders/blood, Neurocognitive Disorders/diagnosis, Cohort Studies, Syndrome, Biomarkers/blood, Cognitive Dysfunction/blood, Cognitive Dysfunction/epidemiology, Mental Status and Dementia Tests, C-reactive protein, Gait, Observational cohort, Risk factor, Quebec, Neurocognitive Disorders, NuAge-CIMA-Quebec, C-Reactive Protein, Cognitive Dysfunction, Biomarkers |
| Popis: | Both motoric cognitive risk (MCR) syndrome and C-reactive protein (CRP) serum levels have been separately associated with increased risk of incident major neurocognitive disorder. The study aims to compare the CRP serum levels of older adults with and without MCR and to examine the associations of MCR and CRP serum levels and their combination with incident major neurocognitive disorder. 915 individuals participating in an older adult’s population-based observational cohort study with a 3-year follow-up design were selected. MCR and CRP serum levels were collected at baseline. Incident major neurocognitive disorder was measured at annual follow-up visits using the Modified Mini-Mental State Examination (≤79/100) and simplified instrumental activity daily living scale ( The prevalence of MCR at baseline assessment was 3.7%. The overall incidence of major neurocognitive disorder was 3.0%. MCR alone (hazard ratio = 25.36 with 95% confidence interval = [6.25–102.95] and p ≤ .001) and MCR with a high CRP serum level (hazard ratio = 5.61, with 95% confidence interval [1.29–24.26] and p = .021) were significantly associated with incident major neurocognitive disorder. MCR is a significant risk factor for predicting major neurocognitive disorder in older adults, while serum CRP levels are not. In addition, serum CRP levels reduce the predictive strength of MCR for major neurocognitive disorder. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glae260 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39913250 https://serval.unil.ch/notice/serval:BIB_4B5907F0DA56 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4B5907F0DA564 https://serval.unil.ch/resource/serval:BIB_4B5907F0DA56.P001/REF.pdf |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Prístupové číslo: | edsair.doi.dedup.....016b9aa0dcc68df52d1f1812247124e9 |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Both motoric cognitive risk (MCR) syndrome and C-reactive protein (CRP) serum levels have been separately associated with increased risk of incident major neurocognitive disorder. The study aims to compare the CRP serum levels of older adults with and without MCR and to examine the associations of MCR and CRP serum levels and their combination with incident major neurocognitive disorder. 915 individuals participating in an older adult’s population-based observational cohort study with a 3-year follow-up design were selected. MCR and CRP serum levels were collected at baseline. Incident major neurocognitive disorder was measured at annual follow-up visits using the Modified Mini-Mental State Examination (≤79/100) and simplified instrumental activity daily living scale ( The prevalence of MCR at baseline assessment was 3.7%. The overall incidence of major neurocognitive disorder was 3.0%. MCR alone (hazard ratio = 25.36 with 95% confidence interval = [6.25–102.95] and p ≤ .001) and MCR with a high CRP serum level (hazard ratio = 5.61, with 95% confidence interval [1.29–24.26] and p = .021) were significantly associated with incident major neurocognitive disorder. MCR is a significant risk factor for predicting major neurocognitive disorder in older adults, while serum CRP levels are not. In addition, serum CRP levels reduce the predictive strength of MCR for major neurocognitive disorder. |
|---|---|
| ISSN: | 1758535X 10795006 |
| DOI: | 10.1093/gerona/glae260 |