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Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis

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Název: Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis
Autoři: Zedtwitz, Katharina von, van Elst, Ludger Tebartz, Urbach, Horst, Groppa, Sergiu, Schiele, Miriam A., Prüss, Harald, Domschke, Katharina, Stich, Oliver, Hannibal, Luciana, Endres, Dominique
Zdroj: J Neural Transm (Vienna)
Journal of neural transmission 131(3), 281-286 (2024). doi:10.1007/s00702-023-02737-z
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Inflammation, Adult, Serotonin, Obsessive-Compulsive Disorder, Psychiatry and Preclinical Psychiatric Studies - Short communication, Multiple Sclerosis, OCD, Multiple Sclerosis/diagnostic imaging [MeSH], Female [MeSH], Immunoglobulin G [MeSH], Brain/pathology [MeSH], Brain/diagnostic imaging [MeSH], Autoimmune, Adult [MeSH], Humans [MeSH], Multiple Sclerosis/complications [MeSH], Magnetic Resonance Imaging [MeSH], Multiple sclerosis, CSF, Obsessive-Compulsive Disorder/diagnostic imaging [MeSH], Serotonin [MeSH], RIS, diagnostic imaging [Multiple Sclerosis], Brain, diagnostic imaging [Obsessive-Compulsive Disorder], Magnetic Resonance Imaging, 3. Good health, pathology [Brain], Immunoglobulin G, Humans, Female, ddc:610, diagnostic imaging [Brain], complications [Multiple Sclerosis]
Popis: Autoimmune-mediated obsessive–compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.
Druh dokumentu: Article
Other literature type
Popis souboru: pdf
Jazyk: English
ISSN: 1435-1463
0300-9564
DOI: 10.1007/s00702-023-02737-z
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38289491
https://pub.dzne.de/record/267982
https://repository.publisso.de/resource/frl:6523003
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....0024e9879a99d6d50c544acf37664844
Databáze: OpenAIRE
Popis
Abstrakt:Autoimmune-mediated obsessive–compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.
ISSN:14351463
03009564
DOI:10.1007/s00702-023-02737-z