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Advamces in intravascular ultrasound (IVUS)-based technology

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Titel: Advamces in intravascular ultrasound (IVUS)-based technology
Autoren: Yu, Mingyue (author)
Verlagsinformationen: University of Southern California Digital Library (USC.DL), 2018.
Publikationsjahr: 2018
Schlagwörter: Biomedical Engineering (degree program), Viterbi School of Engineering (school), Doctor of Philosophy (degree), 3. Good health
Beschreibung: Cardiovascular disease (CVD), the number one killer in the United States, causes around 30.8% of all deaths. Most of CVD is related to a progressive process, atherosclerosis. Atherosclerotic plaque builds up gradually within the artery wall and may remain asymptomatic until high-risk plaque (vulnerable plaque) ruptures, resulting in heart attack or even sudden death. Intravascular ultrasound (IVUS) has frequently been used as a clinical diagnostic tool for intravascular imaging to measure artery lumen dimension and the total plaque volume. However, current IVUS technique is not sufficient for accurate and robust diagnosis of vulnerable plaque, especially regarding image quality and image information. In addition to the diagnostic benefit, the therapeutic value of IVUS in the combined use of microbubbles has also been intensively investigated in recent years. However, a technique for controllable trapping and manipulation of microscopic targets along artery wall is still needed for efficient therapy delivery. ? In this dissertation study, IVUS technique has been advanced in three aspects: 1. applied virtual source synthetic aperture (VSSA) focusing and coherence factor weighting (CFW) to improve IVUS image quality
Publikationsart: Doctoral thesis
Sprache: English
DOI: 10.25549/usctheses-c40-464134
Dokumentencode: edsair.doi...........ba40711bcc166414598f7ff7ebfc09c7
Datenbank: OpenAIRE
Beschreibung
Abstract:Cardiovascular disease (CVD), the number one killer in the United States, causes around 30.8% of all deaths. Most of CVD is related to a progressive process, atherosclerosis. Atherosclerotic plaque builds up gradually within the artery wall and may remain asymptomatic until high-risk plaque (vulnerable plaque) ruptures, resulting in heart attack or even sudden death. Intravascular ultrasound (IVUS) has frequently been used as a clinical diagnostic tool for intravascular imaging to measure artery lumen dimension and the total plaque volume. However, current IVUS technique is not sufficient for accurate and robust diagnosis of vulnerable plaque, especially regarding image quality and image information. In addition to the diagnostic benefit, the therapeutic value of IVUS in the combined use of microbubbles has also been intensively investigated in recent years. However, a technique for controllable trapping and manipulation of microscopic targets along artery wall is still needed for efficient therapy delivery. ? In this dissertation study, IVUS technique has been advanced in three aspects: 1. applied virtual source synthetic aperture (VSSA) focusing and coherence factor weighting (CFW) to improve IVUS image quality
DOI:10.25549/usctheses-c40-464134