Sex differences in dementia risk and risk factors: individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium
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| Title: | Sex differences in dementia risk and risk factors: individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium |
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| Authors: | Gong, J., Harris, K., Lipnicki, D.M., Castro-Costa, E., Lima-Costa, M.F., Diniz, B.S., Xiao, S.F., Lipton, R.B., Katz, M.J., Wang, C.L., Preux, P.M., Guerchet, M., Gbessemehlan, A., Ritchie, K., Ancelin, M.L., Skoog, I., Najar, J., Sterner, T.R., Scarmeas, N., Yannakoulia, M., Kosmidis, M.H., Guaita, A., Rolandi, E., Davin, A., Gureje, O., Trompet, S., Gussekloo, J., Riedel-Heller, S., Pabst, A., Rohr, S., Shahar, S., Singh, D.K.A., Rivan, N.F.M., Boxtel, M. van, Kohler, S., Ganguli, M., Chang, C.C., Jacobsen, E., Haan, M., Ding, D., Zhao, Q.H., Xiao, Z.X., Narazaki, K., Chen, T., Chen, S.M., Ng, T.P., Gwee, X., Numbers, K., Mather, K.A., Scazufca, M., Lobo, A., De-la-Camara, C., Lobo, E., Sachdev, P.S., Brodaty, H., Hackett, M.L., Peters, S.A.E., Woodward, M., Cohort Studies Memory Int Conso |
| Publisher Information: | Wiley, 2023. |
| Publication Year: | 2023 |
| Subject Terms: | 5. Gender equality, risk factor, sex difference, 16. Peace & justice, 10. No inequality, data harmonization, 3. Good health, dementia, diversity |
| Description: | IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| Access URL: | https://hdl.handle.net/1887/3753481 https://pergamos.lib.uoa.gr/uoa/dl/object/3343368 |
| Rights: | CC BY |
| Accession Number: | edsair.dedup.wf.002..d8aa723b14c024d2e9aa687f85d3825e |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men. |
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